Analysis of the functional difference among various Id proteins

• Project/Area Number: 21590307
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General medical chemistry
• Research Institution: Kyoto University
• Principal Investigator: SUGAI Manabu 京都大学, 医学研究科, 講師 (90303891)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 発現制御 / 免疫学 / 遺伝子 / B細胞 / Id2 / Id3 / 活性化

Research Abstract

We have found the differences in activation status between Id2-/-and Id3-/-B cells. To identify the molecular mechanism to explain the phenotypic difference observed in these mice, we performed the DNA array experiments using mRNA probes from Id2-/-or Id3-/-B cells. Drastic changes in gene expressions were observed between them. To elucidate the functional differences of Id2 and Id3 to modulate B cell activation program require more complicated analysis

Research Products

• [Journal Article] Id2controls chondrogenesis acting downstream of BMP signaling during maxillary morphogenesis (2012)
  • Author(s): Sakata-Goto, T., Takahashi, K., Kiso, H., Huang, B., Tsukamoto, H., Takemoto, M., Hayashi, T., Sugai, M. Nakamura, T., Yokota, Y., Shimizu, A., Slavkin, H. and Bessho, K.
  • Journal Title: Bone Volume: 50 Pages: 69-78
  • Peer Reviewed
• [Journal Article] Runx3Is Required for Full Activation of Regulatory T Cells To Prevent Colitis-Associated Tumor Formation (2011)
  • Author(s): Sugai, M. Aoki, K., Osato, M., Nambu, Y., Ito, K., Taketo, M. M., and Shimizu, A
  • Journal Title: J. Immunol. Volume: 186(11)
  • Peer Reviewed
• [Journal Article] Functions of Runx in IgA class switch recombination (2011)
  • Author(s): Sugai, M., Watanabe, K., Nambu, Y., Hayashi, T. and Shimizu, A.
  • Journal Title: J Cellular Biochemistry Volume: 112 Pages: 409-414
  • Peer Reviewed
• [Journal Article] Constitutive expression of activation-induced cytidinedeaminase in adult T-cell leukemia cells (2011)
  • Author(s): Ishikawa, C., Sawada, S., Nakachi, S., Senba, M., Sugai, M. and Mori, N.
  • Journal Title: Carcinogenesis Volume: 32 Pages: 110-119
  • Peer Reviewed
• [Journal Article] ed for Full Activation of Regulatory T Cells To Prevent Colitis-Associated (2011)
  • Author(s): 菅井学, 他
  • Journal Title: The Journal of Immunology Volume: 186 Pages: 6515-6520
  • Peer Reviewed
• [Journal Article] ve expression of activation-induced cytidine deaminase in adult T-cell leuk (2011)
  • Author(s): 石川, 菅井, 他
  • Journal Title: Carcinogenesis Volume: 32 Pages: 110-119
  • Peer Reviewed
• [Journal Article] Functions of Runx in IgA class switch recombination. (2011)
  • Author(s): 菅井学, 他
  • Journal Title: J of Cellular Biochemistry Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Requirement for Runx proteins in IgA class switching acting downstream of TGF-β1 and retinoic acid signaling (2010)
  • Author(s): Watanabe, K., Sugai, M.#, Nambu, Y., Osato, M., Hayashi, T., Kawaguchi, M., Komori, T., Ito, Y., Shimizu, A.
  • Journal Title: J. Immunol. Volume: 184 Pages: 2785-2792
  • Peer Reviewed
• [Journal Article] Requirement for Runx proteins in IgA class switching acting downstream of TGF-beta 1 and retinoic acid signaling. (2010)
  • Author(s): 渡邊翔, 菅井学, 他
  • Journal Title: The Journal of Immunology Volume: 184 Pages: 2785-2792
  • Peer Reviewed
• [Journal Article] Requirement of Runx proteins in IgA class switching acting downstream of TGF-beta 1 and tetinoic acid signaling. (2010)
  • Author(s): 渡邊翔、菅井学, 他
  • Journal Title: The Journal of Immunology 184 Pages: 2785-2792
  • Peer Reviewed
• [Journal Article] CXCL13 production by an established lymph node stromal cell line vialymphotoxin-beta receptor engagement involves the cooperation of multiple signaling pathways (2009)
  • Author(s): Suto, H., Katakai, T., Sugai, M., Kinashi, T., Shimizu, A.
  • Journal Title: Int. Immunol. Volume: 21 Pages: 467-476
  • NAID: 10025385782
  • Peer Reviewed
• [Presentation] Functions of SIP1 in B cell development and AID gene expression (2011)
  • Author(s): 林達成, 南部由希子, 眞野 浩人, 東 雄二郎, Kristin Verschueren, Danny Huylebroeck, 清水章, 菅井 学
  • Organizer: 2011年日本免疫学会学術集会
  • Year and Date: 2011-11-27