Role of Epac2/Rap1 signal in the regulation of insulin secretion in pancreatic-・-cells
| Project/Area Number |
21590308
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Kobe University |
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Principal Investigator |
SHIBASAKI Tadao 神戸大学, 大学院・医学研究科, 講師 (00323436)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 細胞内シグナル伝達 / インスリン分泌 / cAMP / Epac2 / Rap1 / インクレチン / アクチン / actin |
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| Research Abstract |
We have searched for downstream signals of cAMP/Epac2/Rap1 in pancreaticβ-cells and identified several candidate molecules. We have also found that Rho family GTPase Cdc42, which is involved in actin dynamics, is activated by cAMP/Epac2 stimulation in pancreaticβ-cells and its knockdown decreases cAMP-potentiated insulin secretion. These results suggest that Epac2 mediates the potentiation of insulin secretion by cAMP through the activation of several downstream signals.
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Report
(4 results)
Research Products
(85 results)
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[Journal Article] GLP-1 inhibits and adrenaline stimulates glucagon release by differential modulation of N-and L-type Ca^<2+> channel-dependent exocytosis2010
Author(s)
De Marinis YZ, Salehi A, Ward CE, Zhang Q, Abdulkader F, Bengtsson M, Braha O, Braun M, Ramracheya R, Amisten S, Habib AM, Moritoh Y, Zhang E, Reimann F, Rosengren AH, Shibasaki T, Gribble F, Renstrom E, Seino S, Eliasson L, Rorsman P
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Journal Title
Cell Metab
Volume: 11
Pages: 543-553
Related Report
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[Journal Article] Rim2αdetermines docking and priming states in insulin granule exocytosis2010
Author(s)
Yasuda T, Shibasaki T, Minami K, Takahashi H, Mizoguchi A, Uriu Y, Numata T, Mori Y, Miyazak J, Miki T, Seino S
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Journal Title
Cell Metab
Volume: 12
Pages: 117-129
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