| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
We have searched for downstream signals of cAMP/Epac2/Rap1 in pancreaticβ-cells and identified several candidate molecules. We have also found that Rho family GTPase Cdc42, which is involved in actin dynamics, is activated by cAMP/Epac2 stimulation in pancreaticβ-cells and its knockdown decreases cAMP-potentiated insulin secretion. These results suggest that Epac2 mediates the potentiation of insulin secretion by cAMP through the activation of several downstream signals.
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