| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
E-cadherin is a member of the cadherin family cell-cell adhesion molecules. After synthesis in rough endoplasmic reticulum, E-cadherin is transported to the baso-lateral membrane of epithelial cells, and forms cell adhesion complex called adherens junction. Cadherins forms complexes with α-catenin through the interaction with β-catenin. Uncoupling of β-catenin-binding results in failure of cadherin transport to the cell surface. Chimeric molecules of E-cadherin with α-catenin, however, are transported to the surface. Thus complex formation of cadherins with α-catenin is critical for the transport.
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