| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
TMEPAI gene is synergistically activated by both wnt and TGF-β signaling.
C18Orf1, one of TMEPAI family, can inhibit TGF-β signaling like TMEPAI.
Both TMEPAI and C18Orf1 knockout mice were generated. However, no phenotypes for both mice have been observed.
The structure of blood vessels from endothelial cell-specific Smad2/3 double knockout mice seems to be fragile because the expressions of claudin 5, S1PR1 and N-cadherin are reduced in the endothelial cells from those mice.
Endothelial cells from endothelial cell-specific Smad2/3 double knockout mice reveal morphological change when cells receive shear stress.
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