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Elucidation of the function of Aurora kinases in mitosis and itsdysregulation in cancer

Research Project

Project/Area Number 21590331
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pathological medical chemistry
Research InstitutionGifu University

Principal Investigator

KIMURA Masashi  岐阜大学, 医学系研究科, 助教 (40260575)

Co-Investigator(Kenkyū-buntansha) OKANO Yukio  岐阜大学, 医学系研究科, 教授 (10177066)
Project Period (FY) 2009 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywordsがん / オーロラキナーゼ / 細胞分裂 / 細胞死 / 転写制御
Research Abstract

Our study using Aurora inhibitor indicate that Aurora is essentialfor cell division and survival. Several proteins, which are regulated by Aurora kinases,play important roles in mitosis. RNA interference of centrosomal proteins includingAurora A induced cell death, which depended on the checkpoint proteins. The expressionof Aurora A and Plk1 were upregulated in cancer cells, but those of the enzymes whichdegrade them were downregulated.

Report

(5 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (11 results)

All 2013 2012 2011 2009

All Journal Article (11 results) (of which Peer Reviewed: 11 results)

  • [Journal Article] Mitotic catastrophe and cell deathinduced by depletion of centrosomalproteins2013

    • Author(s)
      Kimura, M., Yoshioka, T., Saio, M.,Banno, Y., Nagaoka, H., and Okano, Y
    • Journal Title

      Cell Death Dis

      Volume: 4 Issue: 4 Pages: e603-e603

    • DOI

      10.1038/cddis.2013.108

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a Rho family specificguanine nucleotide exchange factorFLJ00018, as a novel actin-bindingprotein2013

    • Author(s)
      Sato, K., Handa, H., Kimura, M., Okano,Y., Nagaoka, H., Nagase, T., Sugiyama,T., Kitade, Y., and Ueda, H.
    • Journal Title

      Cell. Signal.

      Volume: 25 Issue: 1 Pages: 41-49

    • DOI

      10.1016/j.cellsig.2012.09.015

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Growth suppression and mitotic defect inducedby JNJ-7706621, an inhibitor ofcyclin-dependent kinases and aurorakinases2012

    • Author(s)
      Matsuhashi, A., Ohno, T., Kimura, M.,Hara, A., Saio, M., Nagano, A., Kawai,G., Saitou, M., Takigami, I., Yamada, K.,Okano, Y., and Shimizu, K
    • Journal Title

      Curr. Cancer. Drug. Targets.

      Volume: 12 Pages: 625-639

    • URL

      http://www.eurekaselect.com/98883/article

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Growth suppression and mitotic defect induced by JNJ-7706621, an inhibitor of cyclin-dependent kinases and aurora kinases.2012

    • Author(s)
      Matsuhashi A
    • Journal Title

      Current Cancer Drug Targets

      Volume: 12 Pages: 625-639

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Growth Suppression and Mitotic Defect Induced by JNJ-7706621, an Inhibitor of Cyclin-Dependent Kinases and Aurora Kinases2012

    • Author(s)
      Matsuhashi Aya
    • Journal Title

      Curr Cancer Drug Targets

      Volume: (In press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Plk1 is negativelyregulated by RNF8. Biochem2011

    • Author(s)
      Yoshioka, T., Kimura, M., Saio, M., Era,S., and Okano, Y
    • Journal Title

      Biophys.Res. Commun.

      Volume: 410 Issue: 1 Pages: 57-6

    • DOI

      10.1016/j.bbrc.2011.05.104

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects ofAZD1152, a selective Aurora B kinaseinhibitor, on Burkitt's and Hodgkin's lymphomas2011

    • Author(s)
      Mori, N., Ishikawa, C., Senba, M.,Kimura, M., and Okano, Y.
    • Journal Title

      Biochem. Pharmacol.

      Volume: 81 Issue: 9 Pages: 1106-1115

    • DOI

      10.1016/j.bcp.2011.02.010

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Plk1 is negatively regulated by RNF82011

    • Author(s)
      Yoshioka Takashi
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 410 Pages: 57-61

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of AZD1152, a selective Aurora B kinase inhibitor, on Burkitt's and Hodgkin's lymphomas2011

    • Author(s)
      Mori Naoki
    • Journal Title

      Biochemical Pharmacology

      Volume: 81 Pages: 1106-1115

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aberrantpromoter hypermethylation of the CHFRgene in oral squamous cell carcinomas.2009

    • Author(s)
      Baba, S., Hara, A., Kato, K., Long, N.K.,Hatano, Y., Kimura, M., Okano, Y.,Yamada, Y., and Shibata, T
    • Journal Title

      Oncol. Rep.

      Volume: 22 Pages: 1173-1179

    • URL

      http://www.spandidos-publications.com/or/22/5/1173

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant promoter hypermethylation of the CHFR gene in oral squamous cell carcinomas.2009

    • Author(s)
      Baba Seiji
    • Journal Title

      Oncology Reports 22

      Pages: 1173-1179

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed

URL: 

Published: 2009-04-01   Modified: 2019-07-29  

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