| Project/Area Number |
21590332
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Chubu University (2010-2011)
Nagoya University (2009) |
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Principal Investigator |
KONDO Takaharu 中部大学, 生命健康科学部, 教授 (20135388)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIGURO Hiroshi 名古屋大学, 総合保健体育科学センター, 教授 (90303651)
YAMAMOTO Akiko 名古屋大学, 総合保健体育科学センター, 准教授 (60402385)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | CFTR / NHE3 / HCO_3^-分泌 / SLC26A6 / 膵導管細胞 / 嚢胞性線維症 / 粘膜上皮 / コンピュータシミュレーション / シミュレーションモデル / AE2 / 小葉間膵管 / Cl^--HCO_3^-exchanger / 細胞内pH / 重炭酸イオン輸送 / Na^+-H^+exchange / 単離小葉間膵管 / ΔFマウス / 管腔内pH |
|---|
| Research Abstract |
For the defense mechanisms of gastrointestinal and respiratory mucosa to work properly, pH of the luminal fluid must be kept neutral～ alkaline. The present study demonstrated that the cell membrane transportsome containing CFTR and NHE3 plays a key role in transmucosal HCO_3^-secretion. A mathematical model of HCO_3^-secretion was constructed using MATLAB/Simulink. The kinetic model of each ion channel/transporter/pump was mounted in the basolateral and apical membranes of the model cell.
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