| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
We have performed functional analysis on Goliath(Gol), a novel regulator of Wnt signaling. We have identified an E2 ubiquitin conjugating enzyme which binds to the RING domain of Gol. In addition, by searching for the PA domain-binding proteins, some putative substrates of Gol have also been found. To elucidate in vivo function of Gol, we have generated a Drosophila line in which the gol gene was deleted.
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