Genomic instability in the absence of FANCJ and its possible contribution to tumorigenesis
Project/Area Number |
21590338
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Pathological medical chemistry
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Research Institution | Kyushu University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
TOKUNAGA Eriko 九州大学, 大学病院, 学術研究員 (50325453)
MORITA Masaru 九州がんセンター, 消化器外科, 医師 (30294937)
KAKEJI Yoshihiro 九州大学, 医学研究院, 准教授 (80284488)
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Project Period (FY) |
2009 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 分子腫瘍学 / ファンコニ貧血 / ゲノム不安定性 / FANCJ / BRCA1 / MLH1 |
Research Abstract |
FANCJ is not only one of Fanconi anemia genes but also functions in cooperation with tumor suppressor gene products such as BRCA1 and MLH1. We found that(1) FANCJ deficient cells displayed a characteristic genomic instability phenotype. Moreover, we obtained clinical data that suggest that FANCJ affects anti-tumor effect of 5-FU in colorectal cancer patients.
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Report
(4 results)
Research Products
(45 results)
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[Journal Article] ATR-Chkl signaling pathway and homologous recombinational repair protect cells from 5-fluorouracil cytotoxicity2012
Author(s)
Fujinaka Y, Matsuoka K, Iimori M, Tuul M, Sakasai R, Yoshinaga K, Saeki H, Morita M, Kakeji Y, Gillespie DA, Yamamoto KI, Takata M, Kitao H, Maehara Y
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Journal Title
DNA Repair
Volume: 1(3)
Issue: 3
Pages: 247-58
DOI
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Peer Reviewed
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[Journal Article] High expression of BUBR1 is one of the factors for inducing DNA aneuploidy and progression in gastric cancer2010
Author(s)
Ando K, Kakeji Y, Kitao H, Iimori M, Zhao Y, Yoshida R, Oki E, Yoshinaga K, Matumoto T, Morita M, Sakaguchi Y, Maehara Y
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Journal Title
NAID
Related Report
Peer Reviewed
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[Journal Article] Maehara Y. FANCJ expression predicts the response to 5-fluorouracil-based chemotherapy in MLH1-proficient colorectal cancer
Author(s)
Fujinaka Y, Matsuoka K, Iimori M, Tuul M, Sakasai R, Yoshinaga K, Saeki H, Morita M, Kakeji Y, Gillespie DA, Yamamoto K, Takata M, Kitao H
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Journal Title
Annals of Surgical Oncology(2012) in press
Related Report
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[Journal Article] Maehara Y. ATR-Chk1 signaling pathway and homologous recombinational repair protect cells from 5-fluorouracil cytotoxicity
Author(s)
Fujinaka Y, Matsuoka K, Iimori M, Tuul M, Sakasai R, Yoshinaga K, Saeki H, Morita M, Kakeji Y, Gillespie DA, Yamamoto K, Takata M, Kitao H
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Journal Title
DNA Repair(Amst)
Volume: 11(3)
Pages: 247-58
Related Report
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[Journal Article] High expression of BUBR1 is one of the factors for inducing DNA aneuploidy and progression in gastric cancer
Author(s)
Ando K, Kakeji Y, Kitao H, Iimori M, Zhao Y, Yoshida R, Oki E, Yoshinaga K, Matumoto T, Morita M, Sakaguchi Y, Maehara Y
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Journal Title
Cancer Science
Volume: 101(3)
Pages: 639-45
NAID
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[Presentation] Possible contribution of FancJ in the repair process of 5-FU-induced DNA damages2010
Author(s)
Kitao H, Iimori M, Fujinaka Y, Nakanishi R, Tuul M, Yamashita N, Kubo N, Kakeji Y, Takata M, Maehara Y.
Organizer
22^<nd> Fanconi Anemia Research Fund Annual Meeting
Place of Presentation
Minneapolis, MN
Year and Date
2010-10-21
Related Report
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[Presentation] A novel role of FancJ in the cellular response to 5-FU-induced DNA damages2010
Author(s)
Kitao H, Iimori M, Fujinaka Y, Kubo N, Nakanishi R, Munkhbold T, Yoshinaga K, Tokunaga E, Saeki H, Morita M, Kakeji Y, Takata M, Maehara Y.
Organizer
8^<th> AACR/JCA Conference
Place of Presentation
Hilton Waikoloa Village, Waikoloa, Hawaii, USA
Year and Date
2010-02-09
Related Report
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