| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
Mammalian cells, unlike Saccharomyces cerevisiae, have the mechanism of selective mRNA export. GANP is involved in mRNA export in mammalian cells, and mammary-specific ganp-deficient mice developed mammary gland tumors with lung metastases. Moreover, decreased expression of GANP induced DNA-damage responses leading to the impaired formation of mammary glands. As this abnormality is similar to that observed in Brca1-deficient mice, GANP expression might be associated with the suppression of sporadic breast cancers.
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