| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
Pentosidine, one of advanced glycation end-products(AGEs), is measured by HPLC in the serum, and increased by heating in a temperature-and time-dependent manner. The increase in pentosidine formation is significantly inhibited by acidic conditions. This indicates that the level of serum pentosidine will be measured more accurately by ELISA if hydrochloric acid is added during the heating process. Furthermore, N^ω-carboxymethylarginine(CMA), acid labile AGE structure, is preferentially generated in glycated collagen. We elucidated the hot-spot of CMA formation in glycated collagen.
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