| Project/Area Number |
21590344
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Saitama Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MIZUNO Yosuke 埼玉医科大学, 医学部, 助教 (30406532)
NINOMIYA Yuichi 埼玉医科大学, 医学部, 助教 (70334175)
MIZUNO Yumi 埼玉医科大学, 医学部, 研究員 (20584014)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | Tysnd1 / ペルオキシソーム / プロテアーゼ / 脂肪酸ss-酸化 / 超長鎖脂肪酸 / プラスマローゲン / フィタン酸 / 雄性不妊 / 脂肪酸β-酸化 / Tysndl |
|---|
| Research Abstract |
Tysnd1(Trypsin domain containing 1) is a peroxisomal protease that directly processes peroxisome targeting signal containing enzymes. To clarify the in vivo function and physiological importance of Tysnd1, we analyzed the phenotype of Tysnd1^<-/-> mice. The VLCFA ss-oxidation activity and phytanic acid metabolism of Tysnd1^<-/-> mice was reduced compared to wild type mice. Male Tysnd1^<-/-> mice are infertile, which is most likely the result of a decreased plasmalogen synthesis. These results suggest that peroxisomal processing protease, Tysnd1, is necessary for proper functioning of peroxisomal fatty acid metabolism.
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