Functional analysis of Tysnd1 and its pathogenic mechanism
| Project/Area Number |
21590344
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Saitama Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MIZUNO Yosuke 埼玉医科大学, 医学部, 助教 (30406532)
NINOMIYA Yuichi 埼玉医科大学, 医学部, 助教 (70334175)
MIZUNO Yumi 埼玉医科大学, 医学部, 研究員 (20584014)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | Tysnd1 / ペルオキシソーム / プロテアーゼ / 脂肪酸ss-酸化 / 超長鎖脂肪酸 / プラスマローゲン / フィタン酸 / 雄性不妊 / 脂肪酸β-酸化 / Tysndl |
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| Research Abstract |
Tysnd1(Trypsin domain containing 1) is a peroxisomal protease that directly processes peroxisome targeting signal containing enzymes. To clarify the in vivo function and physiological importance of Tysnd1, we analyzed the phenotype of Tysnd1^<-/-> mice. The VLCFA ss-oxidation activity and phytanic acid metabolism of Tysnd1^<-/-> mice was reduced compared to wild type mice. Male Tysnd1^<-/-> mice are infertile, which is most likely the result of a decreased plasmalogen synthesis. These results suggest that peroxisomal processing protease, Tysnd1, is necessary for proper functioning of peroxisomal fatty acid metabolism.
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Report
(5 results)
Research Products
(27 results)
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[Presentation] Tysnd1 deficiency interferes with mouse peroxisomal functions2011
Author(s)
Yumi Mizuno, Yuichi Ninomiya, Mioko Iseki, Hiroyasu Iwasa, Yutaka Nakachi, Masumi Akita, Toru Tsukui, Chizuru Ito, Kiyotaka Toshimori, Nobuyuki Shimozawa, Megumi Nishimukai, Hiroshi Hara, Ryota Maeba, Tomoki Okazaki, Yasushi Horai, Mitsuhiro Watanabe, Hir
Organizer
第34回日本分子生物学会年会
Place of Presentation
横浜市
Year and Date
2011-12-16
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[Presentation] Tysnd1欠損マウスの機能解析2010
Author(s)
水野由美, 二宮裕一, 伊関美緒子, 穐田真澄, 津久井通, 伊藤千鶴, 年森清隆, 下澤伸行, 茂木浩未, 若菜茂晴, 野田哲生, 西向めぐみ, 原博, 前場良太, 岡崎具樹, Kurochkin Igor V., 岩佐泰靖, 水野洋介, Schoenbach Christian, 岡崎康司
Organizer
BMB2010第33回日本分子生物学会年会第83回日本生化学会大会合同大会
Place of Presentation
神戸市
Year and Date
2010-12-10
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