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Analysis of interchromosomal effect in human using yeast model

Research Project

Project/Area Number 21590346
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pathological medical chemistry
Research InstitutionFujita Health University

Principal Investigator

OHYE Tamae  藤田保健衛生大学, 総合医科学研究所, 助教 (10247661)

Co-Investigator(Kenkyū-buntansha) KURAHASHI Hiroki  藤田保健衛生大学, 総合医科学研究所, 助教 (30243215)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords染色体転座 / 不分離 / 酵母モデル / 減数分裂
Research Abstract

The production of a high proportion of gametes with an unbalanced genetic complement is strictly related to translocations and causes an increased risk of spontaneous abortions and abnormal offspring. The chromosomal abnormalities unrelated to the translocation chromosomes were reported, and it was named as an interchromosomal effect(ICE). However, the existence of the ICE has remained a source of controversy with some studies observing such an effect, whereas others have not. In this project, I analyzed the ICE using a chromosomal translocation yeast model. As a result, the existence or magnitude of the ICE may be influenced by the characteristics of the rearrangement.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (78 results)

All 2012 2011 2010 2009 Other

All Journal Article (28 results) (of which Peer Reviewed: 21 results) Presentation (41 results) Book (9 results)

  • [Journal Article] Molecular basis of maternal age-related increase in oocyte aneuploidy2012

    • Author(s)
      Kurahashi, H., Tsutsumi, M., Nishiyama, S., Kogo, H., Inagaki, H., Ohye, T.
    • Journal Title

      Congenit. Anom

      Volume: 52 Pages: 8-15

    • Related Report
      2011 Final Research Report
  • [Journal Article] Mechanism of complex gross chromosomal rearrangements : a commentary on concomitant microduplications of MECP2 and ATRX in male patients with severe mental retardation2012

    • Author(s)
      Kurahashi, H., Ohye, T., Inagaki, H., Kogo, H., Tsutsumi, M.
    • Journal Title

      J. Hum. Genet

      Volume: 57 Pages: 81-83

    • NAID

      10030711395

    • Related Report
      2011 Final Research Report
  • [Journal Article] Molecular basis of maternal age-related increase in oocyte aneuploidy2012

    • Author(s)
      Kurahashi H, Tsutsumi M, Nishiyama S, Kogo H, Inagaki H, Ohye T
    • Journal Title

      Congenit Anom (Kyoto)

      Volume: 52 Issue: 1 Pages: 8-15

    • DOI

      10.1111/j.1741-4520.2011.00350.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanism of complex gross chromosomal rearrangements : A commentary on Concomitant microduplications of MECP2 and ATRX in male patients with severe mental retardation2012

    • Author(s)
      Kurahashi H, Ohye T, Inagaki H, Kogo H, Tsutsumi M
    • Journal Title

      J Hum Genet

      Volume: 57 Issue: 2 Pages: 81-83

    • DOI

      10.1038/jhg.2011.143

    • NAID

      10030711395

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of a novel mouse gene encoding an SYCP3-like protein that relocalizes from the XY Body to the nucleolus during prophase of male meiosis2011

    • Author(s)
      Tsutsumi, M., Kogo, H., Kowa-Sugiyama, H., Inagaki, H., Ohye, T., Kurahashi, H.
    • Journal Title

      I. Biol. Reprod

      Volume: 85 Pages: 165-171

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] DNA secondary structure is influencec by genetic variation and alters susceptibility to de novo translocation2011

    • Author(s)
      Kato, T., Inagaki, H., Tong, M., Kogo, H., Ohye, T., Yamada, K., Tsutsumi, M., Emanuel, B. S., Kurahashi, H.
    • Journal Title

      Mol. Cytogenet

      Volume: 4 Pages: 18-18

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] DNA secondary structure is influenced by genetic variation and alters susceptibility to de novo translocation2011

    • Author(s)
      Kato T
    • Journal Title

      Mol Cytogenet.

      Volume: 4 Pages: 18-18

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of a novel mouse gene encoding an SYCP3-like protein that relocalizes from the XY body to the nucleolus during prophase of male meiosis I2011

    • Author(s)
      Tsutsumi M
    • Journal Title

      Biol Reprod.

      Volume: 85 Pages: 165-171

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Paternal origin of the de now constitutional t(11 ; 22)(q23 ; q11)2010

    • Author(s)
      Ohye, T., Inagaki, H., Kogo, H., Tsutsumi, M., Kato, T., Tong, M., Macville, M. V. E., Medne, L., Zackai, E. H., Emanuel, B. S., Kurahashi, K.
    • Journal Title

      Eur. J. Hum. Genet

      Volume: 18 Pages: 783-787

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Screening of genes involved in chromosome segregation during meiosis I : towards the identification of genes responsible for infertility in humans2010

    • Author(s)
      Kogo, H., Kowa-Sugiyama, H., Yamada, K., Bolor, H., Tsutsumi, M., Ohye, T., Inagaki, H., Taniguchi, M., Toda, T., Kurahashi, H.
    • Journal Title

      J. Hum. Genet

      Volume: 55 Pages: 293-299

    • NAID

      10030734983

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Polymorphisms of the 22q11.2 breakpoint region influence the frequency of de novo constitutional t(11 ; 22) s in sperm2010

    • Author(s)
      Tong, M., Kato, T., Yamada, K., Inagaki, H., Kogo, H., Ohye, T., Tsutsumi, M., Wang, J., Emanuel, B. S. Kurahashi, H.
    • Journal Title

      Hum. Mol. Genet

      Volume: 19 Pages: 2630-2637

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The constitutional t(11 ; 22): implications for a novel mechanism responsible for gross chromosomal rearrangements2010

    • Author(s)
      Kurahashi, H., Inagaki, H., Ohye, T., Kogo, H., Tsutsumi, M., Kato, T., Emanuel, B. S.
    • Journal Title

      Clin. Genet

      Volume: 78 Pages: 299-309

    • Related Report
      2011 Final Research Report
  • [Journal Article] 絨毛検査で偶然見つかり切断点の解析を必要とした胎児t(11 ; 22)新生転座2010

    • Author(s)
      大江瑞恵, Livija Medne, Beverly S. Emanuel, 倉橋浩樹
    • Journal Title

      遺伝カウンセリング学会誌

      Volume: 31巻 Pages: 169-173

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Paternal origin of the de novo constitutional t(11;22)(q23;q11)2010

    • Author(s)
      Ohye, T.
    • Journal Title

      Eur.J.Hum.Genet.

      Volume: 18 Pages: 783-787

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The constitutional t(11;22) : implications for a novel mechanism responsible for gross chromosomal rearrangements2010

    • Author(s)
      Kurahashi, H.
    • Journal Title

      Clin.Genet.

      Volume: 78 Pages: 299-309

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Polymorphisms of the 22q11.2 breakpoint region influence the frequency of de novo constitutional t(11;22)s in sperm.2010

    • Author(s)
      Tong, M.
    • Journal Title

      Hum Mol Genet.

      Volume: 19 Pages: 2630-2637

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Screening of genes involved in chromosome segregation during meiosis I : towards the identification of genes responsible for infertility in humans2010

    • Author(s)
      Kogo, H.
    • Journal Title

      J.Hum.Genet.

      Volume: 55 Pages: 293-299

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impaired DNA replication prompts deletions within palindromic sequences, but does not induce translocations in human cells2009

    • Author(s)
      Kurahashi, H., Inagaki, H., Kato, T., Hosoba, E., Kogo, H., Ohye, T., Tsutsumi, M., Bolor, H., Tong, M., Emanuel, B. S.
    • Journal Title

      Hum. Mol. Genet

      Volume: 18 Pages: 3397-3406

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Recent advance in our understanding of the molecular nature of chromosomal abnormalities2009

    • Author(s)
      Kurahashi, H., Bolor, H., Kato, T., Kogo, H., Tsutsumi, M., Inagaki, H., Ohye, T.
    • Journal Title

      J. Hum. Genet

      Volume: 54 Pages: 253-260

    • NAID

      10030730167

    • Related Report
      2011 Final Research Report
  • [Journal Article] Mutations of the SYCP3 gene in women with recurrent pregnancy loss2009

    • Author(s)
      Bolor, H., Mori, T., Nishiyama, S., Ito, Y., Hosoba, E., Inagaki, H., Kogo, H., Ohye, T., Tsutsumi, M., Kato, T., Tong, M., Nishizawa, H., Pryor-Koishi, K., Kitaoka, E., Sawada, T., Nishiyama, Y., Udagawa, Y., Kurahashi, H.
    • Journal Title

      Am. J. Hum. Genet

      Volume: 84 Pages: 14-20

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chromosomal instability mediated by non-B DNA : cruciform conformation and not DNA sequence is responsible for recurrent translocation in humans2009

    • Author(s)
      Inagaki, H., Ohye, T., Kogo, H., Kato, T., Bolor, H., Taniguchi, M., Shaikh, T. H., Emanuel, B. S., Kurahashi, H.
    • Journal Title

      Genome. Res

      Volume: 19 Pages: 191-198

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impaired DNA replication prompts deletions within palindromic sequences, but does not induce translocations in human cells2009

    • Author(s)
      Kurahashi, H.
    • Journal Title

      Hum.Mol.Genet. 18

      Pages: 3397-3406

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Recent advance in our understanding of the molecular nature of chromosomal abnormalities2009

    • Author(s)
      Kurahashi, H.
    • Journal Title

      J.Hum.Genet. 54

      Pages: 253-260

    • NAID

      10030730167

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Mutations of the SYCP3 gene in women with recurrent pregnancy loss2009

    • Author(s)
      Bolor, H.
    • Journal Title

      Am.J.Hum.Genet. 84

      Pages: 14-20

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chromosomal instability mediated by non-B DNA : cruciform conformation and not DNA sequence is responsible for recurrent translocation in humans2009

    • Author(s)
      Inagaki, H.
    • Journal Title

      Genome Res. 19

      Pages: 191-198

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Paternal origin of the de novo constitutional t(11 ; 22)(q23 ; q11)

    • Author(s)
      Ohye, T.
    • Journal Title

      Eur.J.Hum.Genet. (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The constitutional t(11 ; 22) : implications for a novel mechanism responsible for gross chromosomal rearrangements

    • Author(s)
      Kurahashi, H.
    • Journal Title

      Clin.Genet. (In press)

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Screening of genes involved in chromosome segregation during meiosis I : towards the identification of genes responsible for infertility in humans

    • Author(s)
      Kogo, H.
    • Journal Title

      J.Hum.Genet. (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Analysis of paternal uniparental disomy of chromosome 9 with supernumerary ring chromosome2011

    • Author(s)
      Ohye, T.
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-14
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Identification of a recombination hotspot sequence at the breakpoint region of the 22q11 deletion using a yeast model2011

    • Author(s)
      Ohye, T.
    • Organizer
      12th International Congress of Human Genetics
    • Place of Presentation
      Montreal, Canada
    • Year and Date
      2011-12-13
    • Related Report
      2011 Final Research Report
  • [Presentation] HORMAD2は哺乳類雌の減数分裂における対合チェックポイントに必要である2011

    • Author(s)
      向後寛
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] Mutation in the SYCP3 gene identified in women with recurrent pregnancy loss affects pairing of the homologous chromosomes during the prophase of meiosis I2011

    • Author(s)
      Makiko Tsutsumi
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] 酵母におけるパリンドロームを介した染色体転座の発生メカニズム2011

    • Author(s)
      大江瑞恵
    • Organizer
      第33回日本分子生物学会年会・第8回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2011-12-07
    • Related Report
      2011 Final Research Report
  • [Presentation] 母由来9番過剰リング染色体をともなった9番染色体父性ダイソミー2011

    • Author(s)
      大江瑞恵
    • Organizer
      第56回日本人類遺伝学会・第ll回東アジア人類遺伝学会共同大会
    • Place of Presentation
      千葉
    • Year and Date
      2011-11-10
    • Related Report
      2011 Final Research Report
  • [Presentation] 母由来9番過剰リング染色体をともなった9番染色体父性ダイソミー2011

    • Author(s)
      大江瑞恵
    • Organizer
      第56回日本人類遺伝学会・第11回東アジア人類遺伝学会共同大会
    • Place of Presentation
      千葉
    • Year and Date
      2011-11-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] 二段階切断によって引き起こされる染色体転座の発生機構2011

    • Author(s)
      稲垣秀人
    • Organizer
      第56回日本人類遺伝学会・第11回東アジア人類遺伝学会共同大会
    • Place of Presentation
      千葉
    • Year and Date
      2011-11-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] Identification of a recombination hotspot sequence at th e breakpoint region of the 22q11 deletion using a yeast model2011

    • Author(s)
      Tamae Ohye
    • Organizer
      12^<th> International Congress of Human Genetics
    • Place of Presentation
      Montreal, Canada
    • Year and Date
      2011-10-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] Mechanism of recurrent translocation t(11;22) initiat ed by cruciform conformation of palindromic sequences2011

    • Author(s)
      Hidehito Inagaki
    • Organizer
      12^<th> International Congress of Human Genetics
    • Place of Presentation
      Montreal, Canada
    • Year and Date
      2011-10-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] HORMAD1-deficiency causes azoospermia in males and pregnancy loss in females2011

    • Author(s)
      Hiroshi Kogo
    • Organizer
      12^<th> International Congress of Human Genetics
    • Place of Presentation
      Montreal, Canada
    • Year and Date
      2011-10-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] Mutation in the SYCP3 gene identified in a woman with recurrent pregnancy loss affect the synaptonemal complex conformation at meiotic prophase I2011

    • Author(s)
      Makiko Tsutsumi
    • Organizer
      12^<th> International Congress of Human Genetics
    • Place of Presentation
      Montreal, Canada
    • Year and Date
      2011-10-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] SYCP3変異による習慣流産の発症メカニズムの解析2011

    • Author(s)
      堤真紀子
    • Organizer
      第43回藤田学園医学会
    • Place of Presentation
      豊明
    • Year and Date
      2011-10-07
    • Related Report
      2011 Annual Research Report
  • [Presentation] 母由来9番過剰マーカー染色体をともなった9番染色体父性ダイソミーの1例2011

    • Author(s)
      大江瑞恵
    • Organizer
      第34回日本小児遺伝学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2011-08-11
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] HORMAD1-dependent synapsis checkpoint in mammalian meiosis2011

    • Author(s)
      Hiroshi Kogo
    • Organizer
      FASEB Summer Research Conferences
    • Place of Presentation
      Steamboat Springs, USA
    • Year and Date
      2011-07-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] 家族性甲状腺髄様癌患者でみられるS891A変異により、非典型症状の副腎褐色細胞腫が初発症状となった1例2011

    • Author(s)
      大江瑞恵
    • Organizer
      遺伝医学合同学術集会
    • Place of Presentation
      京都
    • Year and Date
      2011-06-18
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 対合不全のチェックポイントの男女間の違いと不妊・習慣流産2011

    • Author(s)
      倉橋浩樹
    • Organizer
      文部科学省科学研究費補助金特定領域研究特定領域研究「生殖系列の世代サイクルとエピゲノムネットワーク」第4回公開シンポジウム
    • Place of Presentation
      豊中
    • Related Report
      2011 Final Research Report
  • [Presentation] Fate of two DSBs in reciprocal chromosomal translocation2011

    • Author(s)
      Hidehito Inagaki
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] Detection of cruciform DNA structure in transgenic mouse spermatogenic cells2011

    • Author(s)
      Maoqing Tong
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] 反復性のヒト染色体転座における十字架型構造依存的二重鎖切断の機構2010

    • Author(s)
      稲垣秀人
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会 合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] 酵母におけるパリンドロームを介した染色体転座の発生メカニズム2010

    • Author(s)
      大江瑞恵
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会 合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] GEN1 resolves cruciform-forming palindromic DNA leading to a recurrent translocation in humans.2010

    • Author(s)
      Hidehito Inagaki
    • Organizer
      60th Annual Meeting of The American Society of Human Genetics.
    • Place of Presentation
      Washington D.C., USA
    • Year and Date
      2010-11-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] 一般集団におけるt(11 ; 22)(q23 ; q11)均衡型転座保因者数およびエマヌエル症候群患者数推定の試み2010

    • Author(s)
      大江瑞恵
    • Organizer
      日本人類遺伝学会第55回大会
    • Place of Presentation
      大宮
    • Year and Date
      2010-10-30
    • Related Report
      2011 Final Research Report
  • [Presentation] 一般集団におけるt(11;22)(q23;q11)均衡型転座保因者数およびエマヌエル症候群患者数推定の試み2010

    • Author(s)
      大江瑞恵
    • Organizer
      日本人類遺伝学会 第55回大会
    • Place of Presentation
      大宮
    • Year and Date
      2010-10-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] Two plasmid systemを用いたt(11;22)の発生メカニズムの解析2010

    • Author(s)
      稲垣秀人
    • Organizer
      日本人類遺伝学会 第55回大会
    • Place of Presentation
      大宮
    • Year and Date
      2010-10-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] Paternal origin of the de novo constitutional t(11 ; 22)(q23 ; q11)2010

    • Author(s)
      D Ohye, T.
    • Organizer
      European Human Genetics Conference
    • Place of Presentation
      Gothenburg, Sweden
    • Year and Date
      2010-06-15
    • Related Report
      2011 Final Research Report
  • [Presentation] Paternal origin of the de novo constitutional t(11;22)(q23;q11)2010

    • Author(s)
      Tamae Ohye
    • Organizer
      European Human Genetics Conference 2010
    • Place of Presentation
      Gothenburg, Sweden
    • Year and Date
      2010-06-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] 絨毛検査で偶然見つかり切断点の解析を必要とした胎児t(11 ; 22)新生転座2010

    • Author(s)
      大江瑞恵
    • Organizer
      第34回遺伝カウンセリング学会
    • Place of Presentation
      東京
    • Year and Date
      2010-05-29
    • Related Report
      2011 Final Research Report
  • [Presentation] 絨毛検査で偶然見つかり切断点の解析を必要とした胎児t(11;22)新生転座2010

    • Author(s)
      大江瑞恵
    • Organizer
      第34回遺伝カウンセリング学会
    • Place of Presentation
      東京
    • Year and Date
      2010-05-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] 絨毛検査で偶然見つかり切断点の解析を必要とした胎児t(11 ; 22)新生転座2010

    • Author(s)
      大江瑞恵
    • Organizer
      中部出生前研究会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-03-13
    • Related Report
      2011 Final Research Report
  • [Presentation] Parental origin of de novo t(11 ; 22)(q23 ; q11)2009

    • Author(s)
      Ohye, T.
    • Organizer
      59th annual meeting of American Society of Human Genetic
    • Place of Presentation
      Hawai, USA
    • Year and Date
      2009-12-21
    • Related Report
      2011 Final Research Report
  • [Presentation] Identification of recombination hotspot at the breakpoints of 22q11 deletion using yeast model2009

    • Author(s)
      Ohye, T.
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-12
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] GEN1 resolves cruciform-forming palindromic DNA leading to recurrent translocation in human2009

    • Author(s)
      稲垣秀人
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] HORMAD1は哺乳類雌の対合チェックポイントに必須である2009

    • Author(s)
      向後寛
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] Mechanism of recurrent pregnancy loss with a SYCP3 mutation demonstrated by in vitro culture system of mouse oocytes2009

    • Author(s)
      堤真紀子
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] Parental origin of de novo t(11 ; 22)(q23 ; q11)2009

    • Author(s)
      Ohye, T.
    • Organizer
      59^<th> annual meeting of American Society of Human Genetics
    • Place of Presentation
      Hawai, USA
    • Year and Date
      2009-10-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] Paternal origin of de novo t(11 ; 22)(q23 ; q11)2009

    • Author(s)
      大江瑞恵
    • Organizer
      第41回藤田学園医学会
    • Place of Presentation
      豊明
    • Year and Date
      2009-10-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] 酵母モデルを利用した22ql1欠失切断点にある高頻度組換え配列の同定2009

    • Author(s)
      大江瑞恵
    • Organizer
      第54回日本人類遺伝学会
    • Place of Presentation
      東京
    • Year and Date
      2009-09-24
    • Related Report
      2011 Final Research Report
  • [Presentation] 酵母モデルを利用した22q11欠失切断点にある高頻度組換え配列の同定2009

    • Author(s)
      大江瑞恵
    • Organizer
      第54回日本人類遺伝学会
    • Place of Presentation
      東京
    • Year and Date
      2009-09-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] 遺伝カウンセリング2009

    • Author(s)
      大江瑞恵
    • Organizer
      遺伝子染色体検査研究班例会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-07-11
    • Related Report
      2011 Final Research Report
  • [Presentation] Mutations of the SYCP3 gene in women with recurrent pregnancy loss2009

    • Author(s)
      Kurahashi, H.
    • Organizer
      European Human Genetics Conferences
    • Place of Presentation
      Austria
    • Year and Date
      2009-05-25
    • Related Report
      2011 Final Research Report
  • [Book] 生殖細胞系列の細胞分裂一体細胞分裂と減数分裂の違い、遺伝カウンセリングハンドブック2011

    • Author(s)
      大江瑞恵、倉橋浩樹
    • Total Pages
      2
    • Publisher
      メディカルドゥ
    • Related Report
      2011 Final Research Report
  • [Book] 産婦人科臨床で扱われる染色体異常、産婦人科の実際2011

    • Author(s)
      西山幸江、西澤春紀、大江瑞恵、宇田川康博、倉橋浩樹
    • Publisher
      金原出版
    • Related Report
      2011 Final Research Report
  • [Book] 生殖細胞系列の細胞分裂-体細胞分裂と減数分裂の違い2011

    • Author(s)
      大江瑞恵
    • Total Pages
      2
    • Publisher
      メディカルドゥ
    • Related Report
      2011 Annual Research Report
  • [Book] 産婦人科臨床で扱われる染色体異常2011

    • Author(s)
      西山幸江
    • Publisher
      金原出版
    • Related Report
      2011 Annual Research Report
  • [Book] エマヌエル症候群の臨床像と遺伝、小児科2010

    • Author(s)
      大江瑞恵、倉橋浩樹
    • Total Pages
      8
    • Publisher
      金原出版
    • Related Report
      2011 Final Research Report
  • [Book] エマヌエル症候群の臨床像と遺伝 小児科2010

    • Author(s)
      大江瑞恵
    • Total Pages
      8
    • Publisher
      金原出版
    • Related Report
      2010 Annual Research Report
  • [Book] ここまでわかった染色体異常症の発生メカニズム、小児内科2009

    • Author(s)
      倉橋浩樹、大江瑞恵、ボロル・ハスバイラ、加藤武馬
    • Publisher
      東京医学社
    • Related Report
      2011 Final Research Report
  • [Book] エマヌエル症候群の臨床像と遺伝 小児科

    • Author(s)
      大江瑞恵
    • Publisher
      金原出版(In press)
    • Related Report
      2009 Annual Research Report
  • [Book] 生殖細胞系列の細胞分裂 遺伝カウンセリングハンドブック 遺伝子医学MOOK別冊

    • Author(s)
      大江瑞恵
    • Publisher
      メデイカル ドウ(In press)
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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