| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Research Abstract |
The aims of this research are to understand that the function of Runx transcriptional factors and the identification of target genes of Runx transcriptional factors during regulatory T cell(Treg) development. Treg cell-specific deficiency of Cbfβ, a cofactor for all Runx proteins, or that of Runx1, but not Runx3, induced lymphoproliferation, autoimmune disease, and hyperproduction of IgE. As Cbfβ-deleted Treg cells exhibited impaired suppressive function in vitro and in vivo, Runx transcriptional factors have crucial roles in Treg. We have exhibited that Runx complex regulated Foxp3, IL-4 and IL-10 expression and have identified the expression of several genes were directly regulated Runx transcriptional factors in Treg.
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