| Project/Area Number |
21590353
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | National Center for Geriatrics and Gerontology |
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Principal Investigator |
TAKIKAWA Osamu 独立行政法人国立長寿医療研究センター, ラジオアイソトープ管理室, 室長 (70163342)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KAGAWA Syota 独立行政法人国立長寿医療研究センター, ラジオアイソトープ管理室, 研究員 (30463201)
|
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | アルツハイマー病 / トリプトファン / IFN-γ / ミクログリア / アミロイドβペプチド |
|---|
| Research Abstract |
Alzheimer's disease(AD) is an increasing neurodegenerative disease with growing elderly population. Prevention and treatment of AD is an urgent social issue. In this study, molecular mechanisms of the aberrant metabolism of tryptophan via induction of indoleamine 2, 3-dioxygnase in AD, which leads to a generation of neurotoxin quinolinic acid, was studied. In particular, the putative receptor for amyloid. peptide expressed in activated macrophages infiltrating into amyloid plaques was tried to be characterized.
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