| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Research Abstract |
Focusing on member of polycomb group, Cbx2, we are investigating the relationship between nuclear architecture and gene regulation. In this project, we approved novel Cbx2 functions on growing long bone in mice. Cbx2 KO tibia had low bone mineral densities, and transcription profile in osteoblasts and adipocytes were clearly altered in KO bone marrow, with 60-100% penetrance. In ST2 cells (mouse bone marrow derived stroma cells), Cbx2 and H3k27me3 histone modification were tethering at the same target loci. These results strongly suggested the direct regulation of tissue specific genes by Cbx2.
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