Regulation of lipid metabolism through nucleotide levels in liver by utilizing AMPD2 KO mice
| Project/Area Number |
21590355
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
MORISAKI Hiroko 独立行政法人国立循環器病研究センター, 分子生物学部, 室長 (40311451)
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| Co-Investigator(Kenkyū-buntansha) |
MORISAKI Takayuki 独立行政法人国立循環器病研究センター, 分子生物学部, 部長 (30174410)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 代謝異常学 / アデニンヌクレオチド / 肝臓 / AMP / AMPキナーゼ / 脂質代謝 / AMPD / ATP / 糖脂質代謝 / AMPK / ヌクレオチド代謝 / 遺伝子改変動物 / 代謝異常 |
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| Research Abstract |
Nucleotide metabolism has an important role for lipid metabolism through AMP-activated protein kinase(AMPK) in addition to several known functions. In this study, it was found that the systemic adipose deposition was changed by AMPD2 deficiency. This change was shown to be correlated to changes in the levels of hepatic adenine nucleotide and the phosphorylated condition of AMP. Therefore, the relationship between AMPR2 function and lipid metabolism was newly identified.
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Report
(4 results)
Research Products
(22 results)
