• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Molecular analysis of the CNTN4 knockout mice

Research Project

Project/Area Number 21590359
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Human genetics
Research InstitutionKyushu University

Principal Investigator

IWAKI Akiko  九州大学, 生体防御医学研究所, 講師 (30253454)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords遺伝子改変マウス / 自閉症 / 細胞接着因子 / ゲノム / ゲノム医科学
Research Abstract

Contactin 4(Cntn4) is a member of the immunoglobulin super family of axon associated adhesion molecule. Recently, copy number variations of CNTN4 have been detected in several studies on autism spectrum disorders. To explore the dosage effect of Cntn4, we generated mice with targeted disruption of Cntn4. The knockout(KO) mice were viable and fertile and developed normally. Microarray analyses of the prefrontal cortex and olfactory bulb of KO mice revealed several hundred genes with altered expression levels in comparison with the wild type mice.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (19 results)

All 2012 2011 2010 2009 Other

All Journal Article (13 results) (of which Peer Reviewed: 13 results) Presentation (6 results)

  • [Journal Article] Clinical and genetic characterization of a 2-year-old boy with complete PLP1 deletion2012

    • Author(s)
      Torisu, Iwaki, et al
    • Journal Title

      Brain Dev

      Volume: (In press) Issue: 10 Pages: 852-856

    • DOI

      10.1016/j.braindev.2012.02.006

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An autopsy case of adult-onset hereditary spastic paraplegia type 2 with a novel mutation in exon 7 of the proteolipid protein 1 gene2011

    • Author(s)
      Suzuki SO, Iwaki T, Arakawa K, Furuya H, Fujii N, Iwaki A
    • Journal Title

      Acta Neuropathol

      Volume: 122 Pages: 775-781

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] An autopsied case of sporadic adult-onset amyotrophic lateral sclerosis with FUS-positive basophilic inclusions2011

    • Author(s)
      Matsuoka T, Fujii N, Kondo A, Iwaki A, Hokonohara T, Honda H, Sasaki K, Suzuki SO, Iwaki T
    • Journal Title

      Neuropathology

      Volume: 31 Pages: 71-6

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Partial SPAST and DPY30 deletions in a Japanese spastic paraplegia type 4 family2011

    • Author(s)
      Miura S, Shibata H, Kida H, Noda K, Toyama T, Iwasaki N, Iwaki A, Ayabe M, Aizawa H, Taniwaki T, Fukumaki Y
    • Journal Title

      Neurogenetics

      Volume: 12 Pages: 25-31

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] FALS with FUS mutation in Japan, with early onset, rapid progress and basophilic inclusion2010

    • Author(s)
      Suzuki N, Aoki M, Warita H, Kato M, Mizuno H, Shimakura N, Akiyama T, Furuya H, Hokonohara T, Iwaki A, Togashi S, Konno H, Itoyama Y
    • Journal Title

      J Hum Genet

      Volume: 55 Pages: 252-4

    • NAID

      10030734667

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Multiple system degeneration with basophilic inclusions in Japanese ALS patients with FUS mutation2010

    • Author(s)
      Tateishi T, Hokonohara T, Yamasaki R, Miura S, Kikuchi H, Iwaki A, Tashiro H, Furuya H, Nagara Y, Ohyagi Y, Nukina N, Iwaki T, Fukumaki Y, Kira JI
    • Journal Title

      Acta Neuropathol

      Volume: 119 Pages: 355-364

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comprehensive behavioural study of GluR4 knockout mice : implication in cognitive function2010

    • Author(s)
      Sagata N, Iwaki A, Aramaki T, Takao K, Kura S, Tsuzuki T, Kawakami R, Ito I, Kitamura T, Sugiyama H, Miyakawa T, Fukumaki Y
    • Journal Title

      Genes Brain Behav

      Volume: 9 Pages: 899-909

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comprehensive behavioral study of GluR4 knockout mice, implication in cognitive function.2010

    • Author(s)
      Sagata, N., et al.
    • Journal Title

      Genes Brain Behav.

      Volume: 9 Pages: 899-909

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FALS with FUS mutation in Japan, with early onset, rapid progress and basophilic inclusion.2010

    • Author(s)
      Suzuki N., et al.
    • Journal Title

      J Hum Genet.

      Volume: 55 Pages: 252-254

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An autopsied case of sporadic adult-onset amyotrophic lateral sclerosis with FUS-positive basophilic inclusions.2010

    • Author(s)
      Matsuoka, T., et al.
    • Journal Title

      Neuropathology

      Volume: 31 Pages: 71-76

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multiple system degeneration with basophilic inclusions in Japanese ALS patients with FUS mutation2010

    • Author(s)
      Tateishi, T., et al.
    • Journal Title

      Acta Neuropathol. 119

      Pages: 355-364

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel PLP mutation in a Japanese patient with mild Pelizaeus-Merzbacher disease2009

    • Author(s)
      Kibe, T., et al.
    • Journal Title

      Brain Dev. 31

      Pages: 248-251

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical and genetic characterization of a 2-year-old boy with complete PLP1 deletion

    • Author(s)
      Torisu H, Iwaki A, Takeshita K, Hiwatashi A, Sanefuji M, Fukumaki Y, Hara T
    • Journal Title

      Brain Dev

      Volume: in press

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] Molecular mechanisms of behavioral abnormalities of knockout mice of Grm3.2011

    • Author(s)
      Fujioka R, Nii T, Iwaki A, Kitaichi, K, Ito I, Shibata A, Nomura M, Hattori S, Takao K, Miyakawa T and Fukumaki Y.
    • Organizer
      The 34th Annual Meeting of the Molecular Biology Society of Japan
    • Year and Date
      2011-12-14
    • Related Report
      2011 Final Research Report
  • [Presentation] Molecular mechanisms of behavioral abnormalities of knockout mice of Grm32011

    • Author(s)
      Fujioka, et al
    • Organizer
      The 34^<th> Annual Meeting of the Molecular Biology Society of Japan
    • Place of Presentation
      Yokohama
    • Year and Date
      2011-12-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] Generation and behavioral analysis of GluR4 knockout mice2011

    • Author(s)
      Iwaki A, Sagata N, Aramaki T, Takao K, Miyakawa T, Kawakami R, Ito I, Kitamura T, Sugiyama H, Kura S, Tsuzuki T, Fukumaki Y
    • Organizer
      The 56th Annual Meeting of Japan Society of Human Genetics
    • Year and Date
      2011-11-09
    • Related Report
      2011 Final Research Report
  • [Presentation] Comprehensive behavioral analysis of mGluR3 knockout mice2010

    • Author(s)
      Nii T, Fujioka R, Iwaki A, Hattori S, Takao K, Shibata A, Nomura M, Miyakawa T and Fukumaki Y.
    • Organizer
      The 33 rd Annual Meeting of the Molecular Biology Society of Japan
    • Year and Date
      2010-12-08
    • Related Report
      2011 Final Research Report
  • [Presentation] Generation and analysis of schizophrenia susceptibility candidate gene Grm3 KO mice.2009

    • Author(s)
      Nii T, Iwaki A, Sasaki T, Shibata A, Fukuyoshi Y, Sagata N, Nomura M, Fukumaki Y
    • Organizer
      The 32nd Annual Meeting of the Molecular Biology Society of Japan
    • Year and Date
      2009-12-12
    • Related Report
      2011 Final Research Report
  • [Presentation] Adult-onset spastic paraplegia type 2 with a novel mutation in exon 7 of PLP1An autopsy case2009

    • Author(s)
      Iwaki A, Suzuki SO, Arakawa K, Furuya H, Fujii N, Fukumaki Y, and Iwaki T.
    • Organizer
      59th Annual Meeting of the American Society of Human Genetics
    • Year and Date
      2009-10-21
    • Related Report
      2011 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi