Analysis pathologic processes of FAP development using double humanized mice
Project/Area Number |
21590361
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Human genetics
|
Research Institution | Kumamoto University |
Principal Investigator |
RI Chuhoa 熊本大学, 生命資源研究・支援センター, 特定事業研究員 (80398239)
|
Co-Investigator(Renkei-kenkyūsha) |
YAMAMURA Kenichi 熊本大学, 生命資源研究・支援センター, 教授 (90115197)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 分子遺伝学 / レチノール結合タンパク(RBP) / トランスサイレチン(TTR) / ヒト化マウス / レチノール / レチノール結合タンパク / アミロイド / ES細胞 / 相同組換え / 置換アレル |
Research Abstract |
We successfully produced Rbp4 deficient mice, followed by the establishment of humanized RBP4 mice(Rbp4^<hRBP4>). These mice were mated with Ttr^<hTTR> mice to produce double humanized mice at both Ttr and Rbp4 loci. We obtained expected results from double humanized mice by molecular and biochemical analyses. These mice as optimum mouse model for familial amyloidotic polyneuropathy will be useful to analyze mechanisms for amyloid deposition and to devise a new way of treatment.
|
Report
(4 results)
Research Products
(18 results)