Role of BHD gene in the development of pulmonary cysts and cancer : A molecular-pathological analysis
| Project/Area Number |
21590365
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Chiba University |
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Principal Investigator |
NAKATANI Yukio 千葉大学, 大学院・医学研究院, 教授 (20137037)
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| Co-Investigator(Kenkyū-buntansha) |
FURUYA Mitsuko 横浜市立大学, 大学院・医学研究科, 准教授 (10361445)
YAMAGUCHI Atsushi 千葉大学, 大学院・医学研究院, 准教授 (00314336)
HIROSHIMA Kenzo 東京女子医科大学, 八千代医療センター, 教授 (80218833)
SAKAIRI Yuichi 千葉大学, 医学部附属病院, 医員 (30551949)
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| Research Collaborator |
KOGA Shunsuke 千葉大学, 医学部・附属病院, 後期研修医
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | Birt-Hogg-Dube症候群 / フォリキュリン / 肺嚢胞 / 気胸 / mTOR経路 / BHD症候群 / AMPK経路 |
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| Research Abstract |
Thirteen patients from 10 families underwent genetic analysis of the folliculin gene and were diagnosed as suffering from Birt-Hogg-Dube (BHD) syndrome ; of these, pulmonary cysts resected surgically in 9 patients were studied histopathologically, immunohistochemically and molecular-pathologically. The results suggested the BHD syndrome-associated lung cyst may be a hamartoma-like aberrant cystic alveolar formation possibly caused by mild activation of the mTOR pathway under haploinsufficiency of folliculin.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Pulmonary cysts of Birt-Hogg-Dube syndrome : a clinicopathologic and immunohistochemical study of 9 families2012
Author(s)
Furuya M, Tanaka R, Koga S, Yatabe Y, Gotoda H, Takagi S, Hsu YH, Fujii T, Okada A, Kuroda N, Moritani S, Mizuno H, Nagashima Y, Nagahama K, Hiroshima K, Yoshino I, Nomura F, Aoki I, Nakatani Y
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Journal Title
Am J Surg Pathol
Volume: 36(4)
Pages: 589-600
Related Report
Peer Reviewed
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