| Project/Area Number |
21590365
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Chiba University |
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Principal Investigator |
NAKATANI Yukio 千葉大学, 大学院・医学研究院, 教授 (20137037)
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| Co-Investigator(Kenkyū-buntansha) |
FURUYA Mitsuko 横浜市立大学, 大学院・医学研究科, 准教授 (10361445)
YAMAGUCHI Atsushi 千葉大学, 大学院・医学研究院, 准教授 (00314336)
HIROSHIMA Kenzo 東京女子医科大学, 八千代医療センター, 教授 (80218833)
SAKAIRI Yuichi 千葉大学, 医学部附属病院, 医員 (30551949)
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| Research Collaborator |
KOGA Shunsuke 千葉大学, 医学部・附属病院, 後期研修医
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | Birt-Hogg-Dube症候群 / フォリキュリン / 肺嚢胞 / 気胸 / mTOR経路 / BHD症候群 / AMPK経路 |
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| Research Abstract |
Thirteen patients from 10 families underwent genetic analysis of the folliculin gene and were diagnosed as suffering from Birt-Hogg-Dube (BHD) syndrome ; of these, pulmonary cysts resected surgically in 9 patients were studied histopathologically, immunohistochemically and molecular-pathologically. The results suggested the BHD syndrome-associated lung cyst may be a hamartoma-like aberrant cystic alveolar formation possibly caused by mild activation of the mTOR pathway under haploinsufficiency of folliculin.
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