Diversified studies on the genetic background of high-grade malignant thyroid tumors

• Project/Area Number: 21590367
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Human pathology
• Research Institution: University of Yamanashi
• Principal Investigator: KATOH Ryohei 山梨大学, 大学院・医学工学総合研究部, 教授 (30152755)
• Co-Investigator(Kenkyū-buntansha): KONDO Tetsuo 山梨大学, 大学院・医学工学総合研究部, 准教授 (30334858) ; NAKAZAWA Tadao 山梨大学, 大学院・医学工学総合研究部, 助教 (10345704)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 甲状腺癌 / 未分化癌 / 遺伝子異常 / 低分化癌 / RET遺伝子再構成 / BRAF遺伝子突然変異

Research Abstract

We have performed diversified studies on the genetic background of thyroid cancers and found some interesting findings as follows
1) The point mutation of BRAF gene can play an important role in the progression mechanism from well differentiated thyroid cancer to undifferentiated thyroid cancer.
2) Our studies revealed that RET gene rearrangements and/or PPARγ/PAX8is not important for the undifferentiated progression.
3) It was interesting that aquaporin 4 can be related to follicular cell derived thyroid tumors and not expressed in undifferentiated thyroid carcinoma.
In conclusion, these findings described above can be important for understanding thyroid cancer pathology and molecular therapies.

Research Products

• [Journal Article] Global histone modification of histone H3 in colorectal cancer and its precursor lesions (2011)
  • Author(s): Tadao NAKAZAWA, Tetsuo KONDO, Ryohei KATOH, 他6名
  • Journal Title: HUMAN PATHOLOGY Volume: (In press)
  • Peer Reviewed
• [Journal Article] Fine-needle aspiration biopsy of low-grade cribriform cystadenocarcinoma of the salivary gland (2011)
  • Author(s): Tadao NAKAZAWA, Tetsuo KONDO, RyoheiKATOH, 他8名
  • Journal Title: DIAGNOSTIC CYTOPATHOLOGY Volume: 39(3) Pages: 218-222
  • Peer Reviewed
• [Journal Article] Global histone modification of histone H3 in colorectal cancer and its precursor lesions (2011)
  • Author(s): Tadao NAKAZAWA, et al
  • Journal Title: HUMAN PATHOLOGY Volume: (In Press)
  • Peer Reviewed
• [Journal Article] Fine-needle aspiration biopsy of low-grade cribriform cyst-adenocarcinoma of the salivary gland (2011)
  • Author(s): Tadao NAKAZAWA, et al
  • Journal Title: DIAGNOSTIC CYTOPATHOLOGY Volume: 39(3) Issue: 3 Pages: 218-222
  • DOI: 10.1002/dc.21405
  • Peer Reviewed
• [Journal Article] Unusual thyroid carcinoma with excessive extracellular hyaline globules : a case of "hyalinizing papillary carcinoma" (2011)
  • Author(s): Tetsuo KONDO, et al
  • Journal Title: HUMAN PATHOLOGY Volume: (In Press)
  • Peer Reviewed
• [Journal Article] Hypoxia-inducible adenosine A2B receptor modulates proliferation of colon carcinoma cells (2010)
  • Author(s): Def MA, Tetsuo KONDO, Tadao NAKAZAWA, Ryohei KATOH, 他4名
  • Journal Title: HUMANPATHOLOGY Volume: 41(11) Pages: 1550-1557
  • Peer Reviewed
• [Journal Article] Polyclonal origin of hormone-producing cell populations evaluated as a direct in situ demonstration in EGFP/BALB/Cchimeric mice (2010)
  • Author(s): Def MA, Tetsuo KONDO, Tadao NAKAZAWA, Ryohei KATOH, 他6名
  • Journal Title: JOURNAL OF ENDOCRINOLOGY Volume: 207(1) Pages: 17-25
  • Peer Reviewed
• [Journal Article] RET rearrangements and BRAF mutation in undifferentiated thyroid carcinomas having papillary carcinoma components (2010)
  • Author(s): Kunio MOCHIZUKITetsuo KONDO, Tadao NAKAZAWA, Ryohei KATOH, 他6名
  • Journal Title: HISTOPATHOLOGY Volume: 57(3) Pages: 444-450
  • Peer Reviewed
• [Journal Article] Giant oesophagealliposarcoma mimicking spindle cell liposarcoma and containing eosinophilic cells with rhabdomyoblastic differentiation (2010)
  • Author(s): Tadao NAKAZAWA, Tetsuo KONDO, Ryohei KATOH, 他7名
  • Journal Title: JOURNAL OF CLINICALPATHOLOGY Volume: 63(5) Pages: 469-469
  • Peer Reviewed
• [Journal Article] Hypoxia-inducible adenosine A2B receptor modulates proliferation of colon carcinoma cells (2010)
  • Author(s): Def MA, et al
  • Journal Title: HUMAN PATHOLOGY Volume: 41(11) Pages: 1550-1557
  • Peer Reviewed
• [Journal Article] Giant oesophageal liposarcoma mimicking spindle cell liposarcoma and containing eosinophilic cells with rhabdomyoblastic differentiation (2010)
  • Author(s): Tadao NAKAZAWA, et al
  • Journal Title: JOURNAL OF CLINICAL PATHOLOGY Volume: 63(5) Pages: 469-469
  • Peer Reviewed
• [Journal Article] RET rearrangements and BRAF mutation in undifferentiated thyroid carcinomas having papillary carcinoma components (2010)
  • Author(s): Kunio MOCHIZUKI, et al
  • Journal Title: HISTOPATHOLOGY Volume: 57(3): Pages: 444-450
  • Peer Reviewed
• [Journal Article] Peculiar intracytoplasmic basophilic bodies in papillary thyroid carcinoma (2009)
  • Author(s): Tetsuo KONDO, Tadao NAKAZAWA, Ryohei KATOH
  • Journal Title: ENDOCRINE PATHOLOGY Volume: 20(2) Pages: 145-149
  • Peer Reviewed
• [Journal Article] RET/PTC rearrangements arising from a small population of papillary thyroid carcinoma cells, possible candidate for passenger mutation (2009)
  • Author(s): Tadao NAKAZAWA, Tetsuo KONDO, Ryohei KATOH, 他6名
  • Journal Title: VIRCHOWS ARCHIV Volume: 6(455) Pages: 35-41
  • Peer Reviewed
• [Journal Article] Involvement of centrosomes in nuclear irregularity of thyroid carcinoma Cells (2009)
  • Author(s): Niu DONGFENF, Tetsuo KONDO, Tadao NAKAZAWA, Ryohei KATOH, 他5名
  • Journal Title: VIRCHOWS ARCHIV Volume: 455(2) Pages: 149-157
  • Peer Reviewed
• [Journal Article] Epigenetic silencing of TTF-1/NKX2-1 through DNA hypermethylation and histone H3 modulation in thyroid carcinomas carcinomas. (2009)
  • Author(s): Tetsuo KONDO, Tadao NAKAZAWA, Ryohei KATOH他3名
  • Journal Title: LABORATORY INVESTIGATION Volume: 89(7) Pages: 791-799
  • Peer Reviewed
• [Journal Article] Peculiar intracytoplasmic basophilic bodies in papillary thyroid carcinoma. (2009)
  • Author(s): Tetsuo KONDO, et al
  • Journal Title: ENDOCRINE PATHOLOGY 20(2) Pages: 145-148
  • Peer Reviewed
• [Journal Article] RET/PTC rearrangements arising from a small population of papillary thyroid carcinoma cells, possible candidate for passenger mutation (2009)
  • Author(s): Tadao NAKAZAWA, et al
  • Journal Title: VIRCHOWS ARCHIV 6(455) Pages: 35-41
  • Peer Reviewed
• [Journal Article] Epigenetic silencing of TTF-1/NKX2-1 through DNA hyper-methylation and histone H3 modulation in thyroid carcinomas. (2009)
  • Author(s): Tetsuo KONDO, et al
  • Journal Title: LABORATORY INVESTIGATION 89(7) Pages: 791-199
  • Peer Reviewed
• [Presentation] 甲状腺、胸腺、耳下腺に鰓溝性嚢胞様病変を認めた1例 (2011)
  • Author(s): 中澤匡男、近藤哲夫、加藤良平, 他
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: パシフィコ横浜、横浜市
  • Year and Date: 2011-04-28
• [Presentation] A Genome-wide Screening DNA Methylation Reveals Differential Profiles of Thyroid Neoplasms (2011)
  • Author(s): 近藤哲夫、中澤匡男、加藤良平, 他
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: パシフィコ横浜、横浜市
  • Year and Date: 2011-04-28
• [Presentation] 甲状腺癌において高発現するRunx2は浸潤関連遺伝子を制御している (2011)
  • Author(s): 鈕東峰、近藤哲夫、中澤匡男、加藤良平, 他
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: パシフィコ横浜、横浜市
  • Year and Date: 2011-04-28
• [Presentation] A Genome-wide Screening DNA Methylation Reveals Differential Profiles of Thyroid Neoplasms (2011)
  • Author(s): 近藤哲夫, 他
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: パシフィコ横浜(横浜市)
  • Year and Date: 2011-04-28
• [Presentation] 甲状腺、胸腺、耳下腺に鰓溝性嚢胞様病変を認めた1例 (2011)
  • Author(s): 中澤匡男, 他
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: パシフィコ横浜(横浜市)
  • Year and Date: 2011-04-28
• [Presentation] 甲状腺濾胞性腫瘍の良悪性診断におけるオブザーバーバリエーション (2011)
  • Author(s): 加藤良平
  • Organizer: 第84回日本内分泌学会学術総会
  • Place of Presentation: 神戸市
  • Year and Date: 2011-04-21
• [Presentation] 甲状腺濾胞性腫瘍の良悪性診断におけるオブザーバーバリエーション (2011)
  • Author(s): 加藤良平
  • Organizer: 第84回日本内分泌学会学術総会
  • Place of Presentation: 神戸国際会議場(神戸市)(招待講演)
  • Year and Date: 2011-04-21
• [Presentation] シンポジウム・甲状腺濾胞癌の病理 (2010)
  • Author(s): 近藤哲夫、中澤匡男、加藤良平, 他
  • Organizer: 第14回日本内分泌病理学会学術総会
  • Place of Presentation: ハイヤットリージェンシー京都、京都市
  • Year and Date: 2010-10-29
• [Presentation] 多発甲状腺乳頭癌の発生機序-HUMARA assay- (2010)
  • Author(s): 中澤匡男、近藤哲夫、加藤良平, 他
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 京王プラザホテル、東京都
  • Year and Date: 2010-04-28
• [Presentation] Tumor promoting properties of adenosine receptor A1 in thyroid carcinomas (2010)
  • Author(s): 近藤哲夫、中澤匡男、加藤良平, 他
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 京王プラザホテル、東京都
  • Year and Date: 2010-04-28
• [Presentation] 甲状腺好酸性細胞と好酸性腫瘍の意義とその診断 (2010)
  • Author(s): 加藤良平
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-28
• [Presentation] 甲状腺低分化癌4例の細胞学的検討 (2009)
  • Author(s): 中澤久美子、中澤匡男、近藤哲夫、加藤良平, 他
  • Organizer: 第48回日本臨床細胞学会秋期大会
  • Place of Presentation: JALリゾートシーホークホテル福岡、福岡市
  • Year and Date: 2009-10-30
• [Presentation] 転写因子TTF-のエピジェネティックス制御に関する検討 (2009)
  • Author(s): 近藤哲夫、中澤匡男、加藤良平, 他
  • Organizer: 第13回日本内分泌病理学会学術総会
  • Place of Presentation: 山梨大学甲府キャンパス、甲府市
  • Year and Date: 2009-10-24
• [Presentation] Molecular Pathology of Thyroid Thyroid Transcription Factor-1(TTF-1) (2009)
  • Author(s): Ryohei KATOH
  • Organizer: 2009 6th Asia Pacific IAP Congress
  • Place of Presentation: インド、コーチン
  • Year and Date: 2009-08-20
• [Presentation] Genetic background of progression in thyroid carcinomas (2009)
  • Author(s): Ryohei KATOH
  • Organizer: 2009 6th Asia Pacific IAP Congress
  • Place of Presentation: インド、コーチン
  • Year and Date: 2009-08-20
• [Presentation] Are we overdiagnosing papillary carcinoma of the thyroid (2009)
  • Author(s): Ryohei KATOH
  • Organizer: 2009 6th Asia Pacific IAP Congress
  • Place of Presentation: インド、コーチン
  • Year and Date: 2009-08-20
• [Presentation] Are we overdiagnosing papillary carcinoma of the thyroid? (2009)
  • Author(s): Ryohei KATOH
  • Organizer: 2009 6th Asia pacific IAP Congress
  • Place of Presentation: インド, コーチン
  • Year and Date: 2009-08-20