| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Research Abstract |
We have demonstrated that gene expression pattern of cancer may eventually become genomic dosage-dependent due to the attenuation of epigenetic regulation during tumor progression. If this is true, we can predict the progression risk of the cancer by the pattern of copy-number alterations of specified genes. In gastric cancer(GC), candidates of such genes were found to include many genes related to intestinal expression and epithelial mesenchymal transition in differentiated-type GC and integrin genes in undifferentiated-type GC in addition to MYC and TP53.
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