Biological significance of bone marrow-derived mesenchymal stem cells in tumor microenvironment
| Project/Area Number |
21590370
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Kobe University |
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Principal Investigator |
SEMBA Shuho 神戸大学, 大学院・医学研究科, 准教授 (00302092)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | がん幹細胞 / 骨髄由来間葉系幹細胞 / がん微小環境 / 胃癌 / 大腸癌 / Wnt5a / TGF-β / Snail / WNT5A / 上皮間葉移行 / CD133 |
|---|
| Research Abstract |
Bone marrow-derived mesenchymal stem cells-mediated activations of the WNT and TGF-βsignaling pathways were thought to provide advantageous microenvironments for cancer progression by supporting the re-acquisition and maintenance of cancer stem cells.
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Report
(4 results)
Research Products
(16 results)
