Biological significance of bone marrow-derived mesenchymal stem cells in tumor microenvironment

• Project/Area Number: 21590370
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Human pathology
• Research Institution: Kobe University
• Principal Investigator: SEMBA Shuho 神戸大学, 大学院・医学研究科, 准教授 (00302092)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2011: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: がん幹細胞 / 骨髄由来間葉系幹細胞 / がん微小環境 / 胃癌 / 大腸癌 / Wnt5a / TGF-β / Snail / WNT5A / 上皮間葉移行 / CD133

Research Abstract

Bone marrow-derived mesenchymal stem cells-mediated activations of the WNT and TGF-βsignaling pathways were thought to provide advantageous microenvironments for cancer progression by supporting the re-acquisition and maintenance of cancer stem cells.

Research Products

• [Journal Article] 胃癌細胞と線維芽細胞・間葉系幹細胞の相互作用 (2012)
  • Author(s): 仙波秀峰
  • Journal Title: 胃がんperspective Volume: 5巻 Pages: 14-23
• [Journal Article] Bio logical significance of tumor budd ing at the invasive front of human colo rectal carcinoma cells (2012)
  • Author(s): Ysura, Semba S, Yokozaki H
  • Journal Title: Int J Oncol Volume: 41 Pages: 201-210
  • Peer Reviewed
• [Journal Article] Biological significance of tumor budding at the invasive front of huma colorectal carcinoma cells (2012)
  • Author(s): Yusra, Semba S, Yokozaki H
  • Journal Title: International Journal of Oncology Volume: 41 Pages: 201-210
  • Peer Reviewed
• [Journal Article] 骨髄由来間葉系幹細胞によるがん幹細胞性再獲得機構 (2011)
  • Author(s): 仙波秀峰
  • Journal Title: 顕微鏡 Volume: 46巻 Pages: 89-94
  • NAID: 10029694530
• [Journal Article] Hypoxia induces tumor aggressiveness and the expansion of CD133-positive cells in a hypoxiainducible factor-1α-dependent manner in pancreatic cancer cells (2011)
  • Author(s): Semba S, Chiba S, Ku Y, Yokozaki H, Hori Y
  • Journal Title: Pathobiology Volume: 78 Pages: 181-192
  • Peer Reviewed
• [Journal Article] Regulation of PTEN expression by the SWI/SNF chromatin-remodelling pro tein BRG1 in human colorectal carcin oma cells (2011)
  • Author(s): Watanabe T, Semba S, Yokozaki H
  • Journal Title: Br J Cancer Volume: 104 Pages: 146-154
  • Peer Reviewed
• [Journal Article] Regulation of PTEN expression by SWT/SNF chromatin-remodeling prote in BRG1 in human colorectal carcinoma cells. (2011)
  • Author(s): Watanabe T, Semba S, Yokozaki H.
  • Journal Title: British Journal of Cancer Volume: 104 Pages: 146-154
  • Peer Reviewed
• [Journal Article] 多発胃癌の病理学的特徴 (2011)
  • Author(s): 横崎宏, 仙波秀峰
  • Journal Title: 胃と腸 Volume: 46 Pages: 23-29
• [Journal Article] Requirement of phosphatase of re generating liver-3 for the nucleolar localization of nucleolin during the progression of colorectal carcinoma (2010)
  • Author(s): Semba S, Mizuuchi E, Yokozaki H
  • Journal Title: Cancer Sci Volume: 101 Pages: 2254-2261
  • Peer Reviewed
• [Journal Article] Loss of WW domain-containing oxidoreductase expression in the progression and development of gastric carcinoma : clinical and histopathologic correla tions (2010)
  • Author(s): Maeda N, Semba S, Nakayama S, Yanagihara K, Yokozaki H
  • Journal Title: Virchows Arch Volume: 457 Pages: 423-432
  • Peer Reviewed
• [Journal Article] Constitu tive suppression of PRL-3 inhibits invasion and proliferation of gastric cancer cell in vitro and in vivo (2010)
  • Author(s): Matsukawa Y, Semba S, Kato H, Koma Y, Yanagihara K, Yokozaki H
  • Journal Title: Pathobiology Volume: 77 Pages: 155-162
  • Peer Reviewed
• [Journal Article] Negative regulation of the tight junction protein tricellulin by snail-induced epithelialmesenchymal transition in gastric carcinoma cells (2010)
  • Author(s): Masuda R, Semba S, Mizuuchi E, Yanagihara K, Yokozaki H
  • Journal Title: Pathobiology Volume: 77 Pages: 106-113
• [Journal Article] Direct cancer-stromal interaction increases fibroblast proliferation and enhances invasive properties of scirrhous-type gastric carcinoma cells (2009)
  • Author(s): Semba S, Kodama Y, Ohnuma K, Mizuuchi E, Masuda R, Yashiro M, Hirakawa K, Yokozaki H
  • Journal Title: Br J Cancer Volume: 101 Pages: 1365-1373
• [Journal Article] Direct cancer-stromal interaction increases fibroblast proliferation and Enhances invasive properties of scirrhous-type gastric carcinoma cells (2009)
  • Author(s): Shuho Semba, et al.
  • Journal Title: British Journal of Cancer Vol. 101(18) Pages: 1365-1373
  • Peer Reviewed
• [Journal Article] Hypermethylation-mediated reduction of WWOX expression in intra Ductal papillary mucinous neoplasms of the pancreas (2009)
  • Author(s): Nakayama S, Semba S, et al.
  • Journal Title: British Journal of Cancer Vol. 100 Pages: 1438-1443
  • Peer Reviewed
• [Presentation] 骨髄由来間葉系幹細胞との直接的接触による胃癌細胞の幹細胞性再獲得機構 (2010)
  • Author(s): 仙波秀峰
  • Organizer: 第21回日本消化器癌発生学会
  • Place of Presentation: 軽井沢プリンスホテル(長野県)
  • Year and Date: 2010-11-18