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The analysis of the specific gene expression for castration-resistant prostate cancer in relation to the diagnostic and therapeutic application

Research Project

Project/Area Number 21590372
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionKochi University

Principal Investigator

FURIHATA Mutsuo  高知大学, 教育研究部・医療学系, 教授 (10209158)

Co-Investigator(Renkei-kenkyūsha) NAKAGAWA Hidewaki  理化学研究所, ゲノム医科学研究センターバイオマーカー探索開発チーム, チームリーダー (50361621)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords前立腺癌 / ホルモン療法 / 遺伝子解析 / 病理診断 / 組織化学 / ホルモン非依存性前立腺癌 / 遺伝子発現異常 / マイクロアレイ解析 / RAM / KURO3 / RAML / ELOVL7
Research Abstract

I analyzed the gene expression profiles of castration-resistant prostate cancers(CRPCs) using cDNA microarrays combined with laser microbeam microdissection and found SNRPE and SHISA2, as overexpressed genes in CRPCs. Semi-quantitative RT-PCR confirmed that SNRPE and SHISA2 were overexpressed CRPCs. Knockdown of SNRPE or SHISA2 expression by short interfering RNA resulted in the marked suppression of PC cell proliferation. By contrast, SNRPE or SHISA2 overexpression promoted PC cell proliferation. These findings suggest that SNRPE and SHISA2 are essential for the cell proliferation and progression of CRPC and that they could be potential diagnosis biomarkers for the patient' s prognosis and a molecular target for cancer drugs.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (31 results)

All 2012 2011 2010 2009

All Journal Article (20 results) (of which Peer Reviewed: 20 results) Presentation (11 results)

  • [Journal Article] Comparison between intravesical and oral administration of 5-aminole vulinic acid in the clinical benefit of photodynamic diagnosis for non muscle invasive bladder cancer2012

    • Author(s)
      Inoue K, et al
    • Journal Title

      Cancer

      Volume: 118 Pages: 1062-1074

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] gene deletion activates a local NO-VEGF axis in a balanced manner reinforcing resistance to endothelium-targeted glomerulonephropathy2011

    • Author(s)
      Morita T, Kakinuma Y, Kurabayashi A, Fujieda M, Sato T, Shuin T, Furihata M, Wakiguchi H : Conditional VH
    • Journal Title

      Nephrol Dial Transplant

      Volume: 26 Pages: 4023-4031

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] SNRPE is involved cell proliferation and the progression of high-grade prostate cancer through the regulation of AR expression2011

    • Author(s)
      Anchi T, Tamura K, Furihata M, et al
    • Journal Title

      Oncology Letters

      Volume: 3 Pages: 264-268

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High levels of p-JAK 2 are associated with adverse clinical outcome and can be a molecular target in individuals with acute myelogenous leukemia2011

    • Author(s)
      Ikezoe T, Kojima S, Furihata M, et al
    • Journal Title

      International Journal of Cancer

      Volume: 129 Pages: 2512-2521

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The ubiquitin-like molecule interferon-stimulated gene 15 is overexpressed in human prostate cancer.2010

    • Author(s)
      Satake H, Tamura K, Furihata M, Anchi T, Sakoda H, Kawada C, Iiyama T, Ashida S, Shuin T
    • Journal Title

      Oncol Rep

      Volume: 23(1) Pages: 11-16

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 5alphaDH-DOC(5alpha-dihydro-deoxycorticosterone) activates androgen receptor in castration-resistant prostate cancer2010

    • Author(s)
      Uemura M, Honma S, Chung S, Takata R, Furihata M, Nishimura K, Nonomura N, Nasu Y, Miki T, Shuin T, Fujioka T, Okuyama A, Nakamura Y, Nakagawa H
    • Journal Title

      Cancer Sc

      Volume: 101(8) Pages: 1897-1904

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] AZ960, a novel Jak2 inhibitor, induces growth arrest and apoptosis in adult T-cell leukemia cells2010

    • Author(s)
      Yang J, Ikezoe T, Nishioka C, Furihata M, Yokoyama A
    • Journal Title

      Mol Cancer Ther

      Volume: 9(12) Pages: 3386-395

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The ubiquitin-like molecule interferon-stimulated gene 15 is overexpressed in human prostate cancer.2010

    • Author(s)
      Satake H.
    • Journal Title

      Oncol Rep.

      Volume: 23 Pages: 11-16

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 5alphaDH-DOC(5alpha-dihydro-deoxycorticosterone) activates androgen receptor in castration-resistant prostate cancer.2010

    • Author(s)
      Uemura M.
    • Journal Title

      Cancer Sci.

      Volume: 101(8) Pages: 1897-904

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] AZ960, a novel Jak2 inhibitor, induces growth arrest and apoptosis in adult T-cell leukemia cells.2010

    • Author(s)
      Yang J.
    • Journal Title

      Mol.Cancer Ther.

      Volume: 9(12) Pages: 3386-95

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of Aurora B kinase in non-Hodgkin lymphoma2009

    • Author(s)
      Ikezoe T, Takeuchi T, Yang J, Adachi Y, Nishioka C, Furihata M, Koeffler HP, Yokoyama A
    • Journal Title

      Laboratory Investigation

      Volume: 89(12) Pages: 1364-1373

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chemokine CCL2/ MCP-1 negatively regulates metastasis in a highly bone marrow-metastatic mouse breast cancer model2009

    • Author(s)
      Takahashi M, Miyazaki H, Furihata M, Sakai H, Konakahara T, Watanabe M, Okada T
    • Journal Title

      Clin Exp Metastasis

      Volume: 26(7) Pages: 817-828

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Zeb1-mediated T-cadherin repression increases the invasive potential of gallbladder cancer2009

    • Author(s)
      Adachi Y, Takeuchi T, Nagayama T, Ohtsuki Y, Furihata M
    • Journal Title

      FEBS Lett

      Volume: 583(2) Pages: 430-436

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Overexpressing PKIB in prostate cancer promotes its aggressiveness by linking between PKA and Akt pathways2009

    • Author(s)
      Chung S, Furihata M, Tamura K, Uemura M, Daigo Y, Nasu Y, Miki T, Shuin T, Fujioka T, Nakamura Y, Nakagawa H
    • Journal Title

      Oncogene

      Volume: 28(32) Pages: 2849-2859

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Stanniocalcin 2 overexpression in castration. resistant prostate cancer and aggressive prostate cancer2009

    • Author(s)
      Tamura K, Furihata M, Chung SY, Uemura M, Yoshioka H, Iiyama T, Ashida S, Nasu Y, Fujioka T, Shuin T, Nakamura Y, Nakagawa H
    • Journal Title

      Cancer Sci

      Volume: 100(5) Pages: 914-919

    • NAID

      10025145832

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of the potential kinase serine/ threonine/ tyrosine kinase 1(STYK 1) in castration-resistant prostate cancer2009

    • Author(s)
      Chung S, Tamura K, Furihata M, Uemura M, Daigo Y, Nasu Y, Miki T, Shuin T, Fujioka T, Nakamura Y, Nakagawa H
    • Journal Title

      Cancer Sc

      Volume: 100(11) Pages: 2109-2114

    • NAID

      10027196974

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel lipogenic enzyme ELOVL7 is involved in prostate cancer growth through saturated long-chain fatty acid metabolism2009

    • Author(s)
      Tamura K, Makino A, Hullin-Matsuda F, Kobayashi T, Furihata M, Chung S, Ashida S, Miki T, Fujioka T, Shuin T, Nakamura Y, Nakagawa H
    • Journal Title

      Cancer Res

      Volume: 69(20) Pages: 8133-8140

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Overexpressing PKIB in prostate cancer promotes its aggressiveness by linking between PKA and Akt pathways2009

    • Author(s)
      Chung S.
    • Journal Title

      Oncogene 28(32)

      Pages: 2849-59

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel lipogenic enzyme ELOVL7 is involved in prostate cancer growth through saturated long-chain fatty acid metabolism2009

    • Author(s)
      Tamura K.
    • Journal Title

      Cancer Res. 69(20)

      Pages: 8133-40

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stanniocalcin 2 overexpression in castration-resistant prostate cancer and aggressive prostate cancer2009

    • Author(s)
      Tamura K.
    • Journal Title

      Cancer Sci. 100(5)

      Pages: 914-919

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 前立腺癌細胞で高発現するKURO3遺伝子の同定2011

    • Author(s)
      田村賢司,庵地孝嗣,降幡睦夫,佐竹宏文,蘆田真吾,山崎一郎,井上啓史,執印太郎
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-04
    • Related Report
      2011 Final Research Report
  • [Presentation] 前立腺癌細胞で高発現するRAM遺伝子の同定2011

    • Author(s)
      庵地孝嗣,田村賢司,降幡睦夫,佐竹宏文,蘆田真吾,山崎一郎,井上啓史,執印太郎
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-04
    • Related Report
      2011 Final Research Report
  • [Presentation] 前立腺癌細胞で高発現するKURO3遺伝子の同定2011

    • Author(s)
      田村賢司
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2011-10-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] 前立腺癌細胞で高発現するRAM遺伝子の同定2011

    • Author(s)
      庵地孝嗣
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2011-10-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] 前立腺癌細胞で高発現するRAM遺伝子の同定2010

    • Author(s)
      庵地孝嗣,田村賢司,降幡睦夫,佐竹宏文,山崎一郎,執印太郎
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-24
    • Related Report
      2011 Final Research Report
  • [Presentation] 前立腺癌で高発現するKURO3の同定と機能解析2010

    • Author(s)
      田村賢司,降幡睦夫,庵地孝嗣,佐竹宏文,山崎一郎,執印太郎
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-24
    • Related Report
      2011 Final Research Report
  • [Presentation] 前立腺癌細胞で高発現するRAM遺伝子の同定2010

    • Author(s)
      庵地孝嗣
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場、リーガロイヤルホテル大阪
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] マウス乳癌骨髄高転移モデルにおける単球走化性因子CCL2の役割2009

    • Author(s)
      酒井弘文,高橋宗久,降幡睦夫,小中原猛雄,岡田知子
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-03
    • Related Report
      2011 Final Research Report
  • [Presentation] Adiponectin類似分子C1qTNF6の肝癌血管新生作用2009

    • Author(s)
      竹内保,降幡睦夫
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-02
    • Related Report
      2011 Final Research Report
  • [Presentation] 前立腺癌細胞で高発現するRAM遺伝子の同定2009

    • Author(s)
      庵地孝嗣,田村賢司,降幡睦夫,佐竹宏文,執印太郎
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-02
    • Related Report
      2011 Final Research Report
  • [Presentation] 前立腺癌細胞で高発現するRAM遺伝子の同定2009

    • Author(s)
      庵地孝嗣
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2009-10-02
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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