The analysis of the specific gene expression for castration-resistant prostate cancer in relation to the diagnostic and therapeutic application
| Project/Area Number |
21590372
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Kochi University |
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Principal Investigator |
FURIHATA Mutsuo 高知大学, 教育研究部・医療学系, 教授 (10209158)
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| Co-Investigator(Renkei-kenkyūsha) |
NAKAGAWA Hidewaki 理化学研究所, ゲノム医科学研究センターバイオマーカー探索開発チーム, チームリーダー (50361621)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 前立腺癌 / ホルモン療法 / 遺伝子解析 / 病理診断 / 組織化学 / ホルモン非依存性前立腺癌 / 遺伝子発現異常 / マイクロアレイ解析 / RAM / KURO3 / RAML / ELOVL7 |
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| Research Abstract |
I analyzed the gene expression profiles of castration-resistant prostate cancers(CRPCs) using cDNA microarrays combined with laser microbeam microdissection and found SNRPE and SHISA2, as overexpressed genes in CRPCs. Semi-quantitative RT-PCR confirmed that SNRPE and SHISA2 were overexpressed CRPCs. Knockdown of SNRPE or SHISA2 expression by short interfering RNA resulted in the marked suppression of PC cell proliferation. By contrast, SNRPE or SHISA2 overexpression promoted PC cell proliferation. These findings suggest that SNRPE and SHISA2 are essential for the cell proliferation and progression of CRPC and that they could be potential diagnosis biomarkers for the patient' s prognosis and a molecular target for cancer drugs.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] 5alphaDH-DOC(5alpha-dihydro-deoxycorticosterone) activates androgen receptor in castration-resistant prostate cancer2010
Author(s)
Uemura M, Honma S, Chung S, Takata R, Furihata M, Nishimura K, Nonomura N, Nasu Y, Miki T, Shuin T, Fujioka T, Okuyama A, Nakamura Y, Nakagawa H
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Journal Title
Cancer Sc
Volume: 101(8)
Pages: 1897-1904
Related Report
Peer Reviewed
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[Journal Article] Overexpressing PKIB in prostate cancer promotes its aggressiveness by linking between PKA and Akt pathways2009
Author(s)
Chung S, Furihata M, Tamura K, Uemura M, Daigo Y, Nasu Y, Miki T, Shuin T, Fujioka T, Nakamura Y, Nakagawa H
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Journal Title
Oncogene
Volume: 28(32)
Pages: 2849-2859
Related Report
Peer Reviewed
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[Journal Article] Stanniocalcin 2 overexpression in castration. resistant prostate cancer and aggressive prostate cancer2009
Author(s)
Tamura K, Furihata M, Chung SY, Uemura M, Yoshioka H, Iiyama T, Ashida S, Nasu Y, Fujioka T, Shuin T, Nakamura Y, Nakagawa H
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Journal Title
Cancer Sci
Volume: 100(5)
Pages: 914-919
NAID
Related Report
Peer Reviewed
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[Journal Article] Overexpression of the potential kinase serine/ threonine/ tyrosine kinase 1(STYK 1) in castration-resistant prostate cancer2009
Author(s)
Chung S, Tamura K, Furihata M, Uemura M, Daigo Y, Nasu Y, Miki T, Shuin T, Fujioka T, Nakamura Y, Nakagawa H
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Journal Title
Cancer Sc
Volume: 100(11)
Pages: 2109-2114
NAID
Related Report
Peer Reviewed
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[Journal Article] Novel lipogenic enzyme ELOVL7 is involved in prostate cancer growth through saturated long-chain fatty acid metabolism2009
Author(s)
Tamura K, Makino A, Hullin-Matsuda F, Kobayashi T, Furihata M, Chung S, Ashida S, Miki T, Fujioka T, Shuin T, Nakamura Y, Nakagawa H
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Journal Title
Cancer Res
Volume: 69(20)
Pages: 8133-8140
Related Report
Peer Reviewed
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