| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Research Abstract |
I analyzed the gene expression profiles of castration-resistant prostate cancers(CRPCs) using cDNA microarrays combined with laser microbeam microdissection and found SNRPE and SHISA2, as overexpressed genes in CRPCs. Semi-quantitative RT-PCR confirmed that SNRPE and SHISA2 were overexpressed CRPCs. Knockdown of SNRPE or SHISA2 expression by short interfering RNA resulted in the marked suppression of PC cell proliferation. By contrast, SNRPE or SHISA2 overexpression promoted PC cell proliferation. These findings suggest that SNRPE and SHISA2 are essential for the cell proliferation and progression of CRPC and that they could be potential diagnosis biomarkers for the patient' s prognosis and a molecular target for cancer drugs.
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