Project/Area Number |
21590373
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Human pathology
|
Research Institution | Oita University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
MORIYAMA Masatsugu 大分大学, 医学部, 教授 (90239707)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
|
Keywords | アレイCGH / 腎細胞癌 / 再発 / メチル化 / ゲノム異常 |
Research Abstract |
We analyzed primary and metastatic lesions of renal cell carcinoma(RCC) by array based comparative genomic hybridization(CGH), using genomic DNA extracted from formalin-fixed, paraffin-embedded tissue samples. We identified some different genomic aberrations between two groups. Next, we analyzed the methylation profiles of promoter regions, and also examined gene expression profiles. As a result of these findings, we found that the patients with 9p loss in primary tumors showed significantly lower recurrence(metastasis) free survival rate than the patients without 9p loss. Two genes located in 9p were identified as a candidate gene associated with recurrence and metastasis in RCC.
|