Significance of Annexin A5 in atherothrombosis

• Project/Area Number: 21590374
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Human pathology
• Research Institution: University of Miyazaki
• Principal Investigator: SATO Yuichiro 宮崎大学, 医学部, 助教 (90347055)
• Co-Investigator(Kenkyū-buntansha): MARUTSUKA Kosuke 宮崎大学, 医学部, 准教授 (00239154) ; HATAKEYAMA Kinta 宮崎大学, 医学部, 講師 (60325735) ; YAMASHITA Atsushi 宮崎大学, 医学部, 助教 (90372797)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 人体病理 / 血栓 / 動脈硬化 / Annexin A5 / アテローム血栓症 / アネキシンA5 / 血栓症

Research Abstract

We studied the immunohistochemical study or PCR study of annexin A5 in thrombosis. No apparent annexin A5 was detected in thrombi by immunohistochemical study or PCR study. Next, we examined the annexin A5 by flow chamber study and rabbit thrombosis model. No annexin A5 was detected in these models. Annexin A5 was not associated with thrombosis.

Research Products

• [Journal Article] Characteristics of tumor vessels in squash smears of astrocytic tumors (2011)
  • Author(s): Sato S, Sato Y, Marutsuka K, Takeshima K, Asada Y
  • Journal Title: Cytopathology Volume: 30 Pages: 16-21
  • Peer Reviewed
• [Journal Article] Quantitative analysis of vessels with smooth muscle layer in astrocytic tumors : correlation with histological grade and prognostic significance (2011)
  • Author(s): Sato S, Sato Y, Hatakeyama K, Marutsuka K, Yamashita A, Takeshima H, Asada Y
  • Journal Title: Hist Histopathol Volume: 26 Pages: 497-504
  • Peer Reviewed
• [Journal Article] Human C-reactive protein enhances thrombus formation after neointimal balloon injury in transgenic rabbits. (2011)
  • Author(s): Matsuda S, Yamashita A, Sato Y, Kitajima S, Koike T, Sugita C, Moriguchi-Goto S, Hatakeyama K, Takahashi M, Koshimoto C, Matsuura Y, Iwakiri T, Chen YE, Fan J, Asada Y
  • Journal Title: J Thromb Haemost Volume: 9 Pages: 201-208
  • Peer Reviewed
• [Journal Article] Human C-reactive protein enhances thrombus formation after neointimal balloon injury in transgenic rabbits (2011)
  • Author(s): Matsuda S, Sato Y
  • Journal Title: J Thromb Haemost Volume: 9 Pages: 201-208
  • Peer Reviewed
• [Journal Article] Quantitative analysis of vessels with smooth muscle layer in astrocytic tumors : correlation with histological grade and prognostic significance. (2011)
  • Author(s): Sato S, Sato Y
  • Journal Title: Histol Histopathol Volume: 26 Pages: 497-504
  • Peer Reviewed
• [Journal Article] Inhibition of factor XI reduces thrombus formation in rabbit jugular vein under endothelial denudation and/or blood stasis (2010)
  • Author(s): Takahashi M, Yamashita A, Moriguchi-Goto S, Sugita C, Matsumoto T, Matsuda S, Sato Y, Kitazawa T, Hattori K, Shima M, Asada Y
  • Journal Title: Thromb Res Volume: 125 Pages: 464-70
  • Peer Reviewed
• [Journal Article] Plasma Pentraxin 3, but not high-sensitivity C-reactive protein, is a useful inflammatory biomarker for predicting cognitive impairment in elderly hypertensive patients (2010)
  • Author(s): Yano Y, Matsuda S, Hatakeyama K, Sato Y, Imamura T, Shimada K, Kodama T, Kario K, Asada Y
  • Journal Title: J Gerontol A Biol Sci Med Sci Volume: 65-5 Pages: 547-52
  • Peer Reviewed
• [Journal Article] Pericardial fat inflammation correlates with coronary artery disease (2010)
  • Author(s): Konishi M, Sugiyama S, Sato Y, Oshima S, Sugamura K, Nozaki T, Ohba K, Matsubara J, Sumida H, Nagayoshi Y, Sakamoto K, Utsunomiya D, Awai K, Jinnouchi H, Matsuzawa Y, Yamashita Y, Asada Y, Kimura K, Umemura S, Ogawa H
  • Journal Title: Atherosclerosis Volume: 213-2 Pages: 649-55
  • Peer Reviewed
• [Journal Article] Inhibition of factor XI reduces thrombus formation in rabbit jugular vein under endothelial denudation and/or blood stasis. (2010)
  • Author(s): Takahashi M, Sato Y
  • Journal Title: Thromb Res Volume: 125 Pages: 264-270
  • Peer Reviewed
• [Journal Article] Pericardial fat inflammation correlates with coronary artery disease. (2010)
  • Author(s): Konishi S, Sato Y
  • Journal Title: J Thromb Haemost Volume: 213 Pages: 649-655
  • Peer Reviewed
• [Journal Article] A rare case of amniotic fluid embolism with massive platelet aggregations in pulmonary capillaries. (2010)
  • Author(s): Furukawa S, Sato Y.
  • Journal Title: J Obstet Gynaecol Res. Volume: 36 Pages: 397-400
  • Peer Reviewed
• [Journal Article] Carcinomatous meningitis from adenocarcinoma of the uterine cervix : a case report and literature review. (2010)
  • Author(s): Yamauchi N, Sato Y.
  • Journal Title: J Obstet Gynaecol Res. Volume: 36 Pages: 444-447
  • Peer Reviewed
• [Journal Article] Inhibition of factor XI reduces thrombus formation in rabbit jugular vein under endothelial denudation and/or blood stasis (2010)
  • Author(s): Takahashi M, Sato Y
  • Journal Title: Thromb Res 125 Pages: 264-270
  • Peer Reviewed
• [Journal Article] Critical role of von Willebrand factor and platelet interaction in venous thromboembolism (2009)
  • Author(s): Takahashi M, Sato Y
  • Journal Title: Histol Histopathol 24 Pages: 1391-1398
  • Peer Reviewed
• [Journal Article] Incidence of asymptomatic coronary thrombosis and plaque disruption : comparison of non-cardiac and cardiac deaths among autopsy cases (2009)
  • Author(s): Sato Y, Asada
  • Journal Title: Thromb Res 124 Pages: 19-23
  • Peer Reviewed
• [Presentation] その他の症例卵巣腫瘍 (2011)
  • Author(s): 佐藤勇一郎、浅田祐士郎
  • Organizer: 第34回日本婦人科病理学会
  • Place of Presentation: 東京都
  • Year and Date: 2011-06-11
• [Presentation] Proportion of platelets, fibrin, and red blood cells differs in cardioembolic and atherothrombotic thrombi (2011)
  • Author(s): Sato Y, Ueda H, Hatakeyama K, Yamashita A, Asada Y
  • Organizer: XXIII Congress of International Society on Thrombosis and Haematosis
  • Place of Presentation: Kyoto
• [Presentation] 新しい診断基準を用いた絨毛膜羊膜炎の組織学的検討 (2011)
  • Author(s): 佐藤勇一郎、浅田祐士郎、丸塚浩助、山田直史、鮫島浩、池ノ上克
  • Organizer: 第19回日本胎盤学会
  • Place of Presentation: 東京都千代田区
• [Presentation] Proportion of platelets, fibrin, and red blood cells differs in cardioembolic and atherothrombotic thrombi (2011)
  • Author(s): Sato Y, Asada Y
  • Organizer: XXIII Congress of International Society on Throm bosis and Haematosis
  • Place of Presentation: Kyoto
• [Presentation] トルコ鞍部神経芽腫瘍の1例 (2011)
  • Author(s): 佐藤勇一郎、浅田祐士郎
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: 横浜市
• [Presentation] 特発性門脈圧亢進症に胃原発T細胞リンパ腫を合併した1剖検例 (2011)
  • Author(s): 盛口清香、佐藤勇一郎
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: 横浜市
• [Presentation] 新しい診断基準を用いた絨毛膜羊膜炎の組織学的検討 (2011)
  • Author(s): 佐藤勇一郎、浅田祐士郎
  • Organizer: 第19回日本胎盤学会
  • Place of Presentation: 東京都
• [Presentation] 下垂体領域に発生した悪性リンパ腫の2例 (2011)
  • Author(s): 佐藤信也、佐藤勇一郎
  • Organizer: 第50回日本臨床細胞学会秋期大会
  • Place of Presentation: 東京都
• [Presentation] 結節性硬化症に伴う脳室上衣下巨細胞性星細胞腫の1例 (2011)
  • Author(s): 徳満貴子、佐藤勇一郎
  • Organizer: 第50回日本臨床細胞学会秋期大会
  • Place of Presentation: 東京都
• [Presentation] 癌と転移との鑑別に苦慮したDiffuse large B cell lymphoma, anaplastic variantの1例 (2011)
  • Author(s): 野口裕史、佐藤勇一郎
  • Organizer: 第50回日本臨床細胞学会秋期大会
  • Place of Presentation: 東京都
• [Presentation] 術前の穿刺吸引細胞診で印環細胞癌を考えた浸潤性小葉癌の1例 (2011)
  • Author(s): 花牟禮登美雄、佐藤勇一郎
  • Organizer: 第50回日本臨床細胞学会秋期大会
  • Place of Presentation: 東京都
• [Presentation] 右卵巣腫瘍 (2011)
  • Author(s): 佐藤勇一郎、浅田祐士郎
  • Organizer: 第35回日本婦人科病理学会
  • Place of Presentation: 大分県別府市
• [Presentation] 壊死性血管炎を認めた回腸穿孔の1例 (2010)
  • Author(s): 佐藤勇一郎、石原明、浅田祐士
  • Organizer: 第15回血管病理研究会
  • Place of Presentation: 東京都八王子市
  • Year and Date: 2010-10-23
• [Presentation] 子宮内胎児発育遅延246例の臨床病理学的検討 (2010)
  • Author(s): 佐藤勇一郎、浅田祐士郎
  • Organizer: 第18回日本胎盤学会学術集会
  • Place of Presentation: 熊本市
  • Year and Date: 2010-09-30
• [Presentation] 臍帯動脈血栓症の一例 (2010)
  • Author(s): 佐藤勇一郎、山田直志、木許恭宏、中原彰彦
  • Organizer: 第30回日本小児病理研究会
  • Place of Presentation: 大阪市
  • Year and Date: 2010-09-04
• [Presentation] 主題に関する症例 卵巣腫瘍 (2010)
  • Author(s): 佐藤勇一郎、田中弘之
  • Organizer: 第32回日本婦人科病理学会
  • Place of Presentation: 東京都品川区
  • Year and Date: 2010-06-05
• [Presentation] Decreased expression of CD39 in symptomatic carotid artery plaques (2010)
  • Author(s): Sato Y, Moriguchi-Goto S, Hatakeyama K, Marutsuka K, Asada Y
  • Organizer: The 6th congress of Asia Pacific Society on Thrombosis and Haemostasis
  • Place of Presentation: Bali, Indonesia
• [Presentation] 圧挫標本による脳腫瘍血管の形態学的検討 (2010)
  • Author(s): 佐藤信也、佐藤勇一郎、丸塚浩助、浅田祐士郎
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 東京
• [Presentation] 乏突起膠細胞系腫瘍診断における術中細胞診の有用性 (2010)
  • Author(s): 佐藤信也、徳満貴子、佐藤勇一郎、神田修司、大野昭信、丸塚浩助
  • Organizer: 第49回日本臨床細胞学会秋期大会
  • Place of Presentation: 神戸
• [Presentation] Decreased expression of CD39 in symptomatic carotid artery plaques. (2010)
  • Author(s): Sato Y, Asada Y
  • Organizer: The 6th congress of Asia Pacific Society on Thrombosis and Haemostasis
  • Place of Presentation: Bali, Indonesia
• [Presentation] 良性上皮成分と悪性間葉系成分からなる稀な腎腫瘍の1症例 (2010)
  • Author(s): 鮫島直樹、佐藤勇一郎
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 東京
• [Presentation] 甲状腺に発生したBranchial cleft-like cyst in chronic thyroid itisの1例 (2010)
  • Author(s): 野口裕史、佐藤勇一郎
  • Organizer: 第51回日本臨床細胞学会春期大会
  • Place of Presentation: 横浜市
• [Presentation] 間葉系腫瘍との鑑別が困難であった頭蓋骨髄膜腫の1例 (2010)
  • Author(s): 佐藤信也、佐藤勇一郎
  • Organizer: 第51回日本臨床細胞学会春期大会
  • Place of Presentation: 横浜市
• [Presentation] 右心室血栓症、冠動脈血栓症を伴った特発性好酸球増多症候群の1剖検例 (2009)
  • Author(s): 佐藤勇一郎、畠山金太、丸塚浩介、浅田祐士郎
  • Organizer: 第31回心筋生検研究会
  • Place of Presentation: 大阪吹田市
• [Presentation] 脳腫瘍血管の圧挫標本による形態学的検討 (2009)
  • Author(s): 佐藤信也, 佐藤勇一郎
  • Organizer: 日本臨床細胞学会秋期大会
  • Place of Presentation: 福岡市
• [Presentation] 病理診断に苦慮した重複癌を呈する Peutz-Jeghers 症候群の一例 (2009)
  • Author(s): 頼田顕辞, 佐藤勇一郎
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 京都市
• [Presentation] 消化管間質腫瘍(GIST)における Podoplanin(D2-40)発現の検討 (2009)
  • Author(s): 畠山金太, 佐藤勇一郎
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 京都市
• [Presentation] 巨大嚢胞性変性を伴った臍帯血管腫の一例 (2009)
  • Author(s): 佐藤勇一郎, 松田俊太郎
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 京都市
• [Presentation] 心嚢液に発生した Primary effusion lymphoma 類似の悪性リンパ腫の一例 (2009)
  • Author(s): 野口裕史, 佐藤勇一郎
  • Organizer: 第50回日本臨床細胞学会春期大会
  • Place of Presentation: 東京都新宿区
• [Book] 臍帯異常-胎児死亡と胎盤病理、産科と婦人科 (2011)
  • Author(s): 佐藤勇一郎
• [Book] 冠動脈プラークの病理-虚血性心疾患の基礎知識 (2010)
  • Author(s): 佐藤勇一郎、浅田祐士郎
  • Publisher: 医学書院
• [Book] 冠動脈プラークの病理 虚血性心疾患の基礎知識 (2010)
  • Author(s): 佐藤勇一郎、浅田祐士郎
  • Total Pages: 3
  • Publisher: 医学書院
• [Book] 病理学的見地からみた石灰化 (2009)
  • Author(s): 佐藤勇一郎、浅田祐士郎
  • Publisher: 産業開発機構
• [Book] 心臓血管画像 MOOK2 病理学的見地からみた石灰化 (2009)
  • Author(s): 佐藤勇一郎, 浅田祐士郎
  • Total Pages: 146
  • Publisher: 産業開発機構株式会社
• [Remarks]
  • URL: http://www.miyazaki-med.ac.jp/patho1/index.htm