Role of expression of HAI-1 and LRP11 in Lung Cnacer

• Project/Area Number: 21590375
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Human pathology
• Research Institution: University of Miyazaki
• Principal Investigator: TANAKA Hiroyuki 宮崎大学, 医学部, 助教 (90433060)
• Co-Investigator(Kenkyū-buntansha): KATAOKA Hiroaki 宮崎大学, 医学部, 教授 (10214321)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 肺癌 / HGF : Hepatocyte growth factor / HGF activator inhibitor type-1 / LRP11 : Low density lipoprotein receptor-related protein 11 / HGF:Hepatocyte growth factor / HAI-1:HGF activator inhibitor type-1 / LRP11:Low density lipoprotein receptor-related protein 11 / HAI-1 : HGF activator inhibitor type-1

Research Abstract

1. We found that HAI-1 is expressed by the bronchial respiratory epithelium with basolateral localization.
2. In the injured pulmonary tissue, HAI-1 showed distinct apical translocation in ciliated epithelial cells of the bronchiole.
3. Distinct expression of LRP mRNA was observed in the brain, prostate, testis and lung tissue.
4. Expression of LRP11 mRNA was increased in non-small cell lung cancer as compared with normal lung tissue.
5. In pulmonary adenocarcinoma group, the correlation of clinicopathologic stage and expression ofLRP11 mRNA was suggested.
6. In pulmonary squamous cell carcinoma group, expression of LRP11 mRNA appears to be increased as compared with normal lung tissue.

Research Products

• [Journal Article] Antitumor effect of dehydroxymethylepoxyquinomicin, a small molecule inhibitor of nuclear factor-{kappa} B, on glioblastoma (2012)
  • Author(s): Fukushima T, Kawaguchi M, Yorita K, Tanaka H, Takeshima H, Umezawa K, Kataoka H
  • Journal Title: Neuro Oncol.
  • Peer Reviewed
• [Journal Article] Loss of membrane-bound serine protease inhibitor HAI-1 inducesoral squamous cell carcinoma cells' invasiveness (2012)
  • Author(s): Baba T, Kawaguchi M, Fukushima T, Sato Y, Orikawa H, Yorita K, Tanaka H, Lin CY, Sakoda S, Kataoka H
  • Journal Title: J Pathol Volume: (Epub ahead of print) Issue: 2 Pages: 181-192
  • DOI: 10.1002/path.3993
  • Peer Reviewed
• [Journal Article] Antitumor effect of dehydroxymethylepoxyquinomicin (DHMEQ), a small molecule inhibitor of nuclear factor-κB, on glioblastoma (2012)
  • Author(s): Fukushima T, Kawaguchi M, Yorita K, Tanaka H, Takeshima H, Umezawa K, Kataoka H
  • Journal Title: Neuro-Oncology Volume: 14 Issue: 1 Pages: 19-28
  • DOI: 10.1093/neuonc/nor168
  • Peer Reviewed
• [Journal Article] Hepatocyte growth factor activator inhibitor type 1 suppresses metastaticpulmonary colonization of pancreatic carcinoma cells (2011)
  • Author(s): Fukushima T, Kawaguchi M, Yamasaki M, Tanaka H, Yorita K, Kataoka H
  • Journal Title: Cancer Sci Volume: 102-2 Pages: 407-13
  • Peer Reviewed
• [Journal Article] Improvement ofrheumatoid arthritis and autoimmune hepatitis in a patient treated with the tumor necrosis factor inhibitor, etanercept (2011)
  • Author(s): Umekita K, Miyauchi S, Ueno S, Takajo I, Kusumoto K, Hasuike S, Umekita Y, Tanaka H, Nagata K, Nagatomo Y, Kataoka H, Shimoda K, Okayama A
  • Journal Title: Intern Med Volume: 50-11 Pages: 1245-9
  • Peer Reviewed
• [Journal Article] Improvement of Rheumatoid Arthritis and Autoimmune Hepatitis in a Patient Treated with the Tumor Necrosis Factor Inhibitor, Etanercept (2011)
  • Author(s): Umekita K, Miyauchi S, Ueno S, Takajo I, Kusumoto K, Hasuike S, Umekita Y, Tanaka H, Nagata K, Nagatomo Y, Kataoka H, Shimoda K, Okayama A
  • Journal Title: Internal Medicine Volume: 50 Issue: 11 Pages: 1245-1249
  • DOI: 10.2169/internalmedicine.50.4879
  • NAID: 130000770480
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed
• [Journal Article] Hepatocyte growth factor activator inhibitor type 1 suppresses metastatic pulmonary colonization of pancreatic carcinoma cells (2011)
  • Author(s): Fukushima T, Kawaguchi M, Yamasaki M, Tanaka H, Yorita K, Kataoka H
  • Journal Title: Cancer Sci Volume: 102 Issue: 2 Pages: 407-413
  • DOI: 10.1111/j.1349-7006.2010.01808.x
  • NAID: 10029290246
  • Peer Reviewed
• [Journal Article] Dickkopf-1 is overexpressed in human pancreatic ductal adenocarcinoma cells and is involved in invasive growth (2010)
  • Author(s): Takahashi N, Fukushima T, Yorita K, Tanaka H, Chijiiwa K, Kataoka H
  • Journal Title: Int J Cancer Volume: 126-7 Pages: 1611-20
  • Peer Reviewed
• [Journal Article] Dickkopf-1 is overexpressed in human pancreatic ductal adenoc arcinoma cells and is involved in invasive growth. (2010)
  • Author(s): Takahashi N, Fukushima T, Yorita K, Tanaka H, Chijiiwa K, Kataoka H.
  • Journal Title: International Journal of Cancer. Volume: 126(7) Pages: 1611-1620
  • Peer Reviewed
• [Journal Article] Dickkopf-1 is overexpressed in human pancreatic ductal adenocarcinoma cells and is involved in invasive growth (2010)
  • Author(s): Takahashi N, Fukushima T, Yorita K, Tanaka H, Chijiiwa K, Kataoka H.
  • Journal Title: Int J Cancer 126(7) Pages: 1611-20
  • Peer Reviewed
• [Journal Article] Hepatocyte growth factor activator inhibitor type 1 regulates epithelial to mesenchymal transition through membrane-bound serine proteinases (2009)
  • Author(s): Cheng H, Fukushima T, Takahashi N, Tanaka H, Kataoka H
  • Journal Title: Cancer Res Volume: 69-5 Pages: 1828-35
  • Peer Reviewed
• [Journal Article] Tissue injury alters the site of expression of hepatocyte growth factor activator inhibitor type 1 in bronchial epithelial cells (2009)
  • Author(s): Tanaka H, Fukushima T, Yorita K, Kawaguchi M, Kataoka H
  • Journal Title: Hum Cell Volume: 22-1 Pages: 11-7
  • Peer Reviewed
• [Presentation] Diabetic muscle infarctionと考えられた.1剖検例 (2011)
  • Author(s): 田中弘之、梅北佳子、頼田顕辞、福島剛、片岡寛章
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2011-04-29
• [Presentation] 多彩な組織像を示した卵巣明細胞腺癌の一剖検例 (2010)
  • Author(s): 田中弘之
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-28
• [Presentation] アントラサイクリン関連心筋炎と考えられた一剖検例 (2009)
  • Author(s): 田中弘之
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 京都
  • Year and Date: 2009-05-02
• [Remarks]
  • URL: http://www.med.miyazaki-u.ac.jp/patho2/index.html
• [Remarks]
  • URL: http://www.med.miyazaki-u.ac.jp/patho2/index.html
• [Remarks]
  • URL: http://www.med.miyazaki-u.ac.jp/patho2/index.html
• [Remarks]
  • URL: http://www.med.miyazaki-u.ac.jp/patho2/index.html