| Project/Area Number |
21590376
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Kyorin University (2011)
Yokohama City University (2009-2010) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OKUDELA Koji 横浜市立大学, 医学部, 助教 (10326027)
SHIMOYAMADA Hiroaki 杏林大学, 医学部, 助教 (60381472)
SATO Hanako 聖マリアンナ医科大学, 医学部, 助教 (60438132)
KITAMURA Hitoshi 横浜市立大学, 大学院・医学研究科, 教授 (20094302)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 肺がん / 悪性神経内分泌細胞 / TTF-1 / 肺癌 / 悪性神経内分泌腫瘍 |
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| Research Abstract |
Thyroid transcription factor-1(TTF-1) is frequently expressed in lung adenocarcinomas with peripheral airway epithelium-like phenotype. However, frequent and abundant TTF-1 expression is also paradoxically found in small cell lung cancers, which commonly generate from central airway. The aim of this study was to investigate the expression mechanism of TTF-1 and search downstream molecules regulated by TTF-1.Through this study, it was suggested that TTF-1 expression was not epigenetically regulated and that TTF-1 complicatedly regulated gene expression with other homeobox transcription factors and neuroendocrine-specific basic helix-loop-helix transcription factors cooperatively.
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