Molecular Pathologic Study on the Significance and Roles of Myeloperoxidase and S100A8/A9 Complex in the Pathogenesis of Acute Coronary Syndrome
| Project/Area Number |
21590378
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Osaka City University |
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Principal Investigator |
UEDA Makiko 大阪市立大学, 大学院・医学研究科, 教授 (10137193)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | バイオマーカー / プラーク不安定性 / 急性冠症候群 / プラーク炎症 / 発症予知 |
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| Research Abstract |
The aim of the present study was to clarify the significance and roles of the expression of myeloperoxidase, neopterin, and S100A8/A9 complex in the pathogenesis of coronary plaque destabilization leading to the development of acute coronary syndrome.
In the present study, we clarified that increased expression of neopterin was closely related to the presence of complex lesion morphology, and also revealed distinct immunolocalization of S100A8/A9 complex in macrophages and neutrophils in lesions of patients with acute myocardial infarction. We also reported new information about the relationship between coronary lesion morphology and the magnitude of myeloperoxidase-positive cell infiltration in patients with unstable angina pectoris, based on the results of coronary atherectomy specimens.
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Report
(4 results)
Research Products
(48 results)
