| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
The aim of the present study was to clarify the significance and roles of the expression of myeloperoxidase, neopterin, and S100A8/A9 complex in the pathogenesis of coronary plaque destabilization leading to the development of acute coronary syndrome.
In the present study, we clarified that increased expression of neopterin was closely related to the presence of complex lesion morphology, and also revealed distinct immunolocalization of S100A8/A9 complex in macrophages and neutrophils in lesions of patients with acute myocardial infarction. We also reported new information about the relationship between coronary lesion morphology and the magnitude of myeloperoxidase-positive cell infiltration in patients with unstable angina pectoris, based on the results of coronary atherectomy specimens.
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