| Project/Area Number |
21590381
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Iwate Medical University (2011)
Toho University (2009-2010) |
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Principal Investigator |
UZUKI Miwa 岩手医科大学, 医学部, 講師 (50305992)
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| Co-Investigator(Kenkyū-buntansha) |
SAWAI Takashi 岩手医科大学, 医学部, 教授 (00125577)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 関節リウマチ / ヒアルロン酸 / ヒアルロニダーゼ / 分子量 / 関節液 / 滑膜組織 |
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| Research Abstract |
We examined the expression of hyaluronic acid(HA) synthases(HASs) and Hyaluronidases(Hyals) in damaged articular tissues, and the relationship between them. We also examined the cytotoxicity of HA with low molecular weight(MW) in the synovial fluid of patients with rheumatoid arthritis(RA). In active inflammatory stage of RA, inflammatory cells in synovial tissue produce HAS-3 and the cells may synthesize HA with low MW. In active inflammatory stage of RA, the number of positive cells of hyaluronidase(Hyal)-1 and Hyal-2 increased and HA may be degenerated to lower MW. In some RA cases have high activity of Hyal in synovial fluid. HA with low MW may cause dysfunction of synovial fluid as lubricant and it also has proinflammatory effects, so the balance between HAS1, 2, 3 or Hyals may be important to maintain the joint's function normal.
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