Application of dual-color CISH for pathological diagnosis and extraction of prognostic factors in bone and soft tissue sarcomas
| Project/Area Number |
21590386
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Tokyo Medical University (2011)
Teikyo University (2009-2010) |
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Principal Investigator |
MOTOI Tooru 東京医科大学, 医学部, 兼任講師 (50291315)
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| Co-Investigator(Kenkyū-buntansha) |
KUMAGAI Arisa 帝京大学, 医学部, 教務職員 (50596963)
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| Co-Investigator(Renkei-kenkyūsha) |
IMAMURA Tetsuo 帝京大学, 医学部, 教授 (40010566)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | CISH法 / 肉腫 / 分子病理診断 / 染色体相互転座 / 融合遺伝子 / 遺伝子増幅 / マイクロRNA |
|---|
| Research Abstract |
Accurate pathological diagnosis of sarcoma is indispensable for appropriate therapy. However, rarity and wide variety of histological types make tumor diagnosis difficult. In this study, a detection method which enables simultaneous visualization of morphology and cytogenetic abnormalities under a light microscope is established and verified. The new method is applicable for routine pathological diagnosis without using special equipment for molecular biology. Therefore diagnostic accuracy may be improved by the present method.
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Report
(4 results)
Research Products
(49 results)
