Histopathologic analyses of myocardial bridge and coronary lesion predisposing to myocardial infarction.

• Project/Area Number: 21590388
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Human pathology
• Research Institution: Toho University
• Principal Investigator: ISHIKAWA Yukio 東邦大学, 医学部, 准教授 (30276894)
• Co-Investigator(Kenkyū-buntansha): AKASAKA Yoshikiyo 東邦大学, 医学部, 准教授 (60202511)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 心筋架橋 / 心筋梗塞 / 粥状動脈硬化症 / 血行力学 / 危険因子 / 冠状動脈 / 冠状動脈硬化症 / 不安定プラーク / 左冠状動脈前下行枝 / 動脈硬化症 / 画像解析

Research Abstract

The significance of myocardial bridge on myocardial infarction was investigated by histopathology using autopsied hearts having myocardial bridge. The myocardial bridge was detected in 45% cases in the left anterior descending coronary artery within 150 hearts. The thickness and length of myocardial bridge were significantly larger in the hearts with infarction than those in the hearts without infarction. Unstable plaque-related lesions were mainly located in the intima 2-5cm far from the ostium of myocardial bridge. The myocardial bridge has a role as an anatomical risk factor for an occurrence of myocardial infarction via hemodynamic alteration in the segment proximal to the myocardial bridge.

Research Products

• [Journal Article] Myocardial bridging on coronary CTA : an innocent bystander or a culprit in myocardial infarction? (2012)
  • Author(s): Nakanishi R, Rajani R, Ishikawa Y, Ishii T, Berman DS
  • Journal Title: J Cardiovasc Comp tomogr Volume: 6 Pages: 3-13
  • Peer Reviewed
• [Journal Article] Significance of the Anatomical Properties of a Myocardial Bridge in Coronary Heart Disease (2011)
  • Author(s): Ishikawa Y, Kawawa Y, Kohda E, Shimada K, Ishii T
  • Journal Title: Circulation Journal Volume: 75 Issue: 7 Pages: 1559-1566
  • DOI: 10.1253/circj.CJ-10-1278
  • NAID: 10029126127
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed
• [Journal Article] Anatomical characteristics of myocardial bridge in patients with myocardial infarction by multi-detector computed tomography (2011)
  • Author(s): Takamura K, Fujimoto S, Nanjo S, Nakanishi R, Hisatake S, Namiki A, Ishikawa Y, Ishii T, Yamazaki J
  • Journal Title: Circ Y Volume: 75 Pages: 642-648
  • NAID: 10028102147
  • Peer Reviewed
• [Journal Article] Anatomical characteristics of myocardial bridge in patients with myocardial infarction ny multi-detector computed tomography. (2011)
  • Author(s): Takamura K, Fujimoto S, Nanjo S, Nakanishi R, Hisatake S, Namiki A, Ishikawa Y, Ishii T.
  • Journal Title: Circulation Journal Volume: 75 Pages: 642-648
  • Peer Reviewed
• [Journal Article] Anatomic Properties of Myocardial Bridge Predisposing to Myocardial Infarction (2009)
  • Author(s): Ishikawa Y, et al.
  • Journal Title: Circulation 120 Pages: 376-383
  • Peer Reviewed
• [Journal Article] Coronary Events Caused by Myocardial Bridge (2009)
  • Author(s): Ishikawa Y, et al.
  • Journal Title: Annals of Vascular Diseases 2 Pages: 79-94
  • Peer Reviewed
• [Journal Article] Histopathologic profiles of coronary atherosclerosis by myocardial bridge underlying myocardial infarction
  • Author(s): Ishikawa Y, Akasaka Y, Akishima-Fukasawa Y, Iuchi A, et al
  • Journal Title: Atherosclerosis Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Significance of anatomical properties of a myocardial bridge in coronary heart disease.
  • Author(s): Ishikawa Y, Kawawa Y, Kohda E, Shimada K, Ishii T.
  • Journal Title: Circulation Journal Volume: (In press)
  • NAID: 10029126127
  • Peer Reviewed
• [Presentation] 左冠状動脈前下行枝の内膜病変に与える心筋架橋被覆部の解剖学的環境の影響 (2012)
  • Author(s): 井内亜美、石川由起雄、赤坂喜清、深澤由里、下川伶子、木下利雄、小竹遥香、石井壽晴
  • Organizer: 第101回日本病理学会総会
  • Place of Presentation: 東京(新宿、京王プラザホテル)
  • Year and Date: 2012-04-27
• [Presentation] 教育講演「心筋架橋による心筋梗塞の発生」 (2012)
  • Author(s): 石川由起雄
  • Organizer: 第139回東邦医学会定例会
  • Place of Presentation: 東京(東邦大学)
  • Year and Date: 2012-02-10
• [Presentation] 心筋梗塞発生の基盤となる心筋架橋が左冠状動脈前下行枝の内膜病変進展に及ぼす意義 (2011)
  • Author(s): 石川由起雄、赤坂喜清、鈴木高祐、藤原美恵子、向井清、新野史、田中道雄、森永正二郎、小沼純子、下川伶子、緒方謙太郎、川原穣、杉浦仁、品川俊人、滝本寿朗、飯田(柳田)真岐、澁谷和俊、高橋啓、宇月美和、深澤(秋嶋)由里、石井壽晴
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: 横浜(みなとみらい、パシフィコ横浜)
  • Year and Date: 2011-04-30
• [Presentation] 心筋梗塞発生の基盤となる心筋架橋が左冠状動脈前下行枝の内膜病変に及ぼす意義 (2011)
  • Author(s): 石川由起雄, 他20名
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-04-30
• [Presentation] 心筋梗塞発症の原因となる心筋架橋の解剖学的特性の特定と冠状動脈内膜病変の解析 (2010)
  • Author(s): 石川由起雄
  • Organizer: 第64回東邦医学会総会
  • Place of Presentation: 東京(東邦大学)
  • Year and Date: 2010-11-12
• [Presentation] 心筋梗塞発症の原因となる心筋架橋の解剖学的特性の特定と冠状動脈内膜病変の解析 (2010)
  • Author(s): 石川由起雄
  • Organizer: 第64回東邦医学会総会
  • Place of Presentation: 東邦大学医学部大森臨床講堂(東京都)
  • Year and Date: 2010-11-12
• [Presentation] 心筋梗塞の解剖学的危険因子としての心筋架橋の解剖学的特性 (2009)
  • Author(s): 石川由起雄、石井壽晴
  • Organizer: 第50回日本脈管学会総会
  • Place of Presentation: 東京(新宿、ハイアットリージェンシー東京)
  • Year and Date: 2009-10-30
• [Presentation] 心筋梗塞の解剖学的危険因子としての心筋架橋の解剖学的特性 (2009)
  • Author(s): 石川由起雄, 石井壽晴
  • Organizer: 第50回日本脈管学会総会
  • Place of Presentation: 東京、ハイアットリージェンシー東京
  • Year and Date: 2009-10-30
• [Presentation] 心筋梗塞の新たな危険因子としての心筋架橋の解剖学的特性 (2009)
  • Author(s): 石川由起雄、赤坂喜清、鈴木高祐、藤原美恵子、小川高史、山崎一人、新野史、田中道雄、緒方謙太郎、森永正二郎、川原穣、杉浦仁、滝本寿郎、小松明男、品川俊人、瀧和博、佐藤英章、山田和昭、柳田-飯田真岐、下川伶子、石井壽晴
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 京都(京都宝ヶ池国際会館)
  • Year and Date: 2009-05-01