| Project/Area Number |
21590389
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MINATO Hiroshi 金沢医科大学, 医学部, 教授 (10293367)
MIURA Yutaka 名古屋市立大学, 医学部, 准教授 (90285198)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | 骨軟部腫瘍 / 病理診断 / 悪性度評価 / ATBF1 / 遺伝子解析 / ATBF1遺伝子 |
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| Research Abstract |
ATBF1(AT-motif binding factor 1) was discovered as a transcriptional regulator of α-fetoprotein. Thereafter, ATBF1 had a regulatory mechanism of a neuronal and skeletal muscular differentiation, and was a homeotic transcriptional regulatory factor identified as a tumor suppressor gene. We analyzed an immunohistochemical expression and function of ATBF1 on bone and soft tissue tumors. As a result, nuclear staining was observed in most cases of benign or low grade malignant tumor groups, however, in high grade malignant tumor group, one case showed nuclear positivity. Comparing nuclear staining negative group with nuclear staining positive group, we can imply that ATBF1 expression may have potential as a prognostic indicator for bone and soft tissue tumors.
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