A study of histological grading on bone and soft tissue tumors by analysis of ATBF1

• Project/Area Number: 21590389
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Human pathology
• Research Institution: Kanazawa Medical University
• Principal Investigator: NOJIMA Takayuki 金沢医科大学, 医学部, 教授 (50142732)
• Co-Investigator(Kenkyū-buntansha): MINATO Hiroshi 金沢医科大学, 医学部, 教授 (10293367) ; MIURA Yutaka 名古屋市立大学, 医学部, 准教授 (90285198)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
• Keywords: 骨軟部腫瘍 / 病理診断 / 悪性度評価 / ATBF1 / 遺伝子解析 / ATBF1遺伝子

Research Abstract

ATBF1(AT-motif binding factor 1) was discovered as a transcriptional regulator of α-fetoprotein. Thereafter, ATBF1 had a regulatory mechanism of a neuronal and skeletal muscular differentiation, and was a homeotic transcriptional regulatory factor identified as a tumor suppressor gene. We analyzed an immunohistochemical expression and function of ATBF1 on bone and soft tissue tumors. As a result, nuclear staining was observed in most cases of benign or low grade malignant tumor groups, however, in high grade malignant tumor group, one case showed nuclear positivity. Comparing nuclear staining negative group with nuclear staining positive group, we can imply that ATBF1 expression may have potential as a prognostic indicator for bone and soft tissue tumors.

Research Products

• [Journal Article] Extra-axial soft tissue chordoma of wrist (2011)
  • Author(s): H. Suzuki, K. Yamashiro, H. Takeda, T. Nojima, M. Usui
  • Journal Title: Pathol Res Prac Volume: 207 Pages: 327-331
  • Peer Reviewed
• [Journal Article] 軟部腫瘍の分類と診断へのアプローチ (2010)
  • Author(s): 野島孝之
  • Journal Title: 臨床病理 Volume: 58 Pages: 352-357
  • NAID: 10026444805
• [Journal Article] Desmoplastic small round cell tumour successfully treated with caffeine-assisted chemotherapy. A case report and review of the literature (2010)
  • Author(s): S. Miwa, S. Kitamura, T. Shirai, K. Hayashi, H. Nishida, A. Takeuchi, T. Nojima, H. Tsuchiya
  • Journal Title: Anticancer Res Volume: 30 Pages: 3769-3774
  • Peer Reviewed
• [Journal Article] Induction of HITS, a newly identified family with sequence similarity 107 protein(FAM107B), in cancer cells by heat shock stimulation (2010)
  • Author(s): H. Nakajima, Y. Ishigaki, QS. Xia, T. Ikeda, Y. Yoshitake, H. Yonekura, T. Nojima, T. Tanaka, H. Umehara, N. Tomosugi, T. Takata, T. Shimasaki, N. Nakaya, I. sato, K. Kawakami, K. Koizumi, T. Minamoto, Y. Motoi
  • Journal Title: Int. J. Oncol Volume: 37 Issue: 3 Pages: 583-593
  • DOI: 10.3892/ijo_00000707
  • Peer Reviewed
• [Journal Article] 生検標本による軟部肉腫の組織型・悪性度判定における病理診断の問題点 (2010)
  • Author(s): 小田義直, 的野浩士, 松浦傑, 恒吉正澄, 長谷川匡, 野島孝之, 岩本幸英
  • Journal Title: 日整会誌 Volume: 84 Pages: 1114-1119
  • NAID: 10027708499
  • Peer Reviewed
• [Journal Article] Induction of HITS, a newly identified family with sequence similarity 107 protein (FAM107B), in cancer cells by heat shock stimulation (2010)
  • Author(s): H.Nakajima
  • Journal Title: Int.J.Oncol. Volume: 37 Pages: 583-593
  • Peer Reviewed
• [Journal Article] Adenomatoid tumor of the pleura (2009)
  • Author(s): H. Minato, T. Nojima, N. Kurose, E. Kinoshita
  • Journal Title: Pathol. Int Volume: 59 Issue: 8 Pages: 567-571
  • DOI: 10.1111/j.1440-1827.2009.02407.x
  • NAID: 10027381200
  • Peer Reviewed
• [Journal Article] Primary localized malignant biphasic mesothelioma of the liver in a patient with asbestosis (2009)
  • Author(s): M.Sasaki
  • Journal Title: World J.Gastroentrol. 15 Pages: 615-621
  • Peer Reviewed
• [Journal Article] Adenomatoid tumor of the pleura (2009)
  • Author(s): H.Minato
  • Journal Title: Pathol.Int. 59 Pages: 567-571
  • NAID: 10027381200
  • Peer Reviewed
• [Presentation] ATBF1 is highly phosphorylated in embryonic brain (2011)
  • Author(s): S. Zhang, Y. Dong, M. Kawaguchi, TS. Kim, S. Kanazawa, K. Asai, H. Minato, T. Nojima, Y. Miura
  • Organizer: 第34回日本分子生物学会
  • Place of Presentation: パシフィコ横浜(横浜市)
  • Year and Date: 2011-12-16
• [Presentation] ATBF1 is highly phosphorylated in embryonic brain (2011)
  • Author(s): S.Zhang
  • Organizer: 第34回日本分子生物学会
  • Place of Presentation: 横浜市(パシフィコ横浜)
  • Year and Date: 2011-12-16
• [Presentation] Leiomyosarcoma of bone (2010)
  • Author(s): T. Nojima
  • Organizer: 37^<th> International Skeletal Society Annual Meeting
  • Place of Presentation: Hilton Hotel(Athens, Greece)
  • Year and Date: 2010-09-28
• [Presentation] Leiomyosarcoma of bone (2010)
  • Author(s): T.Nojima
  • Organizer: 37^<th> International Skeletal Society Annual Meeting
  • Place of Presentation: Athens (Greece)
  • Year and Date: 2010-09-28
• [Presentation] 骨軟部腫瘍の病理診断のピットフォール (2009)
  • Author(s): 野島孝之
  • Organizer: 日本病理学会関東支部第44回学術集会
  • Place of Presentation: 帝京大学(東京都)
  • Year and Date: 2009-09-19
• [Presentation] 軟部腫瘍の分類と診断へのアプローチ (2009)
  • Author(s): 野島孝之
  • Organizer: 第56回日本臨床検査医学会学術集会
  • Place of Presentation: 札幌コンベンションセンター(札幌市)
  • Year and Date: 2009-08-27