| Project/Area Number |
21590390
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Fukuoka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Shotaro 九州大学, 大学病院, 助教 (10243932)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2011: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | intestine / malignant lymphoma / c-Met / MAP kinase / c-Myc / H. pylori / FISH / CGH / gastric lymphoma / intestinal lymphoma / H pylori / East Asian CagA gene / East Asian VacA gene |
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| Research Abstract |
Coeliac disease and associating enteropathy-associated T-cell lymphoma(EATL) are frequently found in European Caucasians. Approximately 80% of enteropathy-associated T-cell lymphoma(EATL) cases present with CD56-negative, CD8-negative and CD30-positive large-cell lymphoma(type I). The remaining cases are classified as type II EATL and they present with CD56-and CD8-positive and CD30-negative monomorphic medium-sized lymphomas. In examined 32 cases of Japanese EATL, type II(CD56-and CD8-positive, CD30-negative medium-sized) lymphoma was common(85%) in Japan. HLA DQB102 homo-, heterozygosities and chromosomal amplification of 9q33-34, which are encountered in the Caucasian cases, were absent in the examined cases of Japanese EATL. Asian EATL cases are associated with peculiar pathological and genetic findings as well as histological features. Bacterial cytotoxic associated gene(Cag) A of East Asian H. pylori contributes to neoplastic transformation of gastric epithelium through the proto-oncogene c-Met, tyrosine kinase(p-SHP) 2 and mitogen-activated protein kinase(MAPK) pathway. Enteropathy-like lesions and CagA of East Asian H. pylori were detected in about half cases of tumor tissue in EATL, and expressions of c-Met, p-SHP2 and MAPK as well as chromosomal amplifications of c-Met(7q31) and c-Myc(8q24) were frequently found in cases of EATL. Intestinal bacterial florae including H. pylori may influence tumorgenesis in EATL.
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