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Analyses for malignant degree of carcinomas based on epithelial-mesenchymal transition, histological characteristics and biological characteristics of carcinoma cells.

Research Project

Project/Area Number 21590393
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionNational Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East

Principal Investigator

HASEBE Takahiro  独立行政法人国立がん研究センター, 東病院, 医長 (00250209)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords乳癌 / 癌間質 / 上皮間葉移行 / 癌悪性度 / 異型腫瘍間質線維芽細胞 / リンパ管腫瘍塞栓 / 静脈腫瘍塞栓 / 予後分類 / 異型線維芽細胞 / 上皮間質移行 / 予後 / 腫瘍細胞間質細胞化生
Research Abstract

p53 protein expression in tumor-stromal fibroblasts was closely associated with the number of nodal metastasis and the outcome of invasive ductal carcinoma(IDC) patients of the breast who received and who did not receive neoadjuvant therapy. Furthermore, the Allred score risk classification based on the combined assessment of p53 expression in tumor-stromal fibroblasts forming and not forming FFs is a very useful outcome predictor among patients with IDC who did not receive neoadjuvant therapy.
The grading system for lymph vessel tumor emboli was an excellent histological outcome predictive grading system for IDC patients who received and who did not receive neoadjuvant therapy.
The presence of atypical tumor-stromal fibroblasts, especially in fibrotic foci, was significantly associated with tumor recurrence and tumor-related death of patients with IDC of the breast who received and who did not receive neoadjuvant therapy.
The presence of six or more mitotic figures in a lymph node tumor … More significantly increased the hazard ratios for tumor recurrence and tumor-related death among IDC patients as a whole, those with nodal metastases, and those with a histologic grade of 2 or 3.
Type 4 IDC was significant outcome predictors for lymph node-negative and-positive, UICC pTNM stages II and III, luminal A-subtype, luminal B-subtype, and equivocal HER2 subtype IDC patients. Lymph vessel tumor embolus grades 2 and 3 were significant outcome predictors for lymph node-positive, UICC pTNM stages II and III, luminal A-subtype and triple negative IDC patients. A more than five mitotic figures in metastatic carcinoma to the lymph nodes was a significant outcome predictor for lymph node-positive, UICC pTNM stage II and luminal A-subtype IDC patients. A fibrotic focus diameter> 8 mm was a significant outcome predictor for UICC pTNM stages I and III IDC patients.
The modified PVN classification clearly exhibited a superior significant power, compared with UICC pTNM classification and the reclassified Nottingham Prognostic Index, for the accurate prediction of tumor recurrence and tumor-related death among patients with IDC in a manner that was independent of the nodal status, the hormone receptor status and adjuvant therapy status. Less

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (36 results)

All 2011 2010 2009

All Journal Article (28 results) (of which Peer Reviewed: 28 results) Presentation (8 results)

  • [Journal Article] Prognostic significance of mitotic figures in metastatic mammary ductal carcinoma to the lymph nodes2011

    • Author(s)
      Hasebe T, Iwasaki M, Akashi-Tanaka S, Hojo T, Shibata T, Sasajima Y, Kinoshita T, Tsuda H
    • Journal Title

      Hum Pathol

      Volume: 42 Issue: 12 Pages: 1823

    • DOI

      10.1016/j.humpath.2011.02.015

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Important histological outcome predictors for patients with invasive ductal carcinoma of the breast2011

    • Author(s)
      Hasebe T, Iwasaki M, Akashi-Tanaka S, Hojo T, Shibata T, Kinoshita T, Tsuda H
    • Journal Title

      Am J Surg Pathol

      Volume: 35 Issue: 10 Pages: 1484-1497

    • DOI

      10.1097/pas.0b013e318224ca28

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Modified primary tumour/vessel tumour/nodal tumour classification for patients with invasive ductal carcinoma of the breast2011

    • Author(s)
      Hasebe T, Iwasaki M, Akashi-Tanaka S, Hojo T, Shibata T, Kinoshita T, Tsuda H
    • Journal Title

      Br J Cancer

      Volume: 105 Issue: 5 Pages: 698

    • DOI

      10.1038/bjc.2011.279

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Atypical tumor-stromal fibroblasts in invasive ductal carcinomas of the breast treated with neoadjuvant therapy2011

    • Author(s)
      Hasebe T, Iwasaki M, Akashi-Tanaka S, Hojo T, Shimizu C, Andoh M, Fujiwara Y, Shibata T, Sasajima Y, Kinoshita T, Tsuda H
    • Journal Title

      Hum Pathol

      Volume: 42 Issue: 7 Pages: 998

    • DOI

      10.1016/j.humpath.2010.10.020

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Atypical tumor-stromal fibroblasts in invasive ductal carcinoma of the breast2011

    • Author(s)
      Hasebe T, Iwasaki M, Akashi-Tanaka S, Hojo T, Shibata T, Sasajima Y, Kinoshita T, Tsuda H
    • Journal Title

      Am J Surg Pathol

      Volume: 35 Issue: 3 Pages: 325

    • DOI

      10.1097/pas.0b013e31820afab9

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Atypical tumor-stromal fibroblasts in invasive ductal carcinoma of the breast.2011

    • Author(s)
      Hasebe T, et al.
    • Journal Title

      Am J Surg Pathol

      Volume: 35 Pages: 325-336

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Atypical tumor-stromal fibroblasts in invasive ductal carcinoma of the breast treated with neoadjuvant therapy.2011

    • Author(s)
      Hasebe T, et al.
    • Journal Title

      Hum Pathol

      Volume: In press

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic significance of mitotic figures in metastatic mammary ductal carcinoma to the lymph nodes.2011

    • Author(s)
      Hasebe T, et al.
    • Journal Title

      Hum Pathol

      Volume: In press

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Metaplastic carcinoma of the breast2010

    • Author(s)
      O kada N, Hasebe T, Iwasaki M, Tamura N, Akashi-Tanaka S, Hojo T, Shibata T, Sasajima Y, Kanai Y, Kinoshita T
    • Journal Title

      Hum Pathol

      Volume: 41 Pages: 960-970

    • URL

      http://dx.doi.org/10.1016/j.humpath.2009.11.013

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] P53 expression in tumor-stromal fibroblasts forming and not forming fibrotic foci in invasive ductal carcinoma of the breast2010

    • Author(s)
      Hasebe T, Iwasaki M, Akashi-Tanaka S, Hojo T, Shibata T, Sasajima Y, Kinoshita T, Tsuda H
    • Journal Title

      Mod Pathol

      Volume: 23 Issue: 5 Pages: 662

    • DOI

      10.1038/modpathol.2010.47

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Grading system for lymph vessel tumor emboli: Significant outcome predictor for patients with invasive ductal carcinoma of the breast who received neoadjuvant therapy2010

    • Author(s)
      Hasebe T, Tamura N, Iwasaki M, Okada N, Akashi-Tanaka S, Hojo T, Shimizu C, Shibata T, Sasajima Y, Tsuda H, Kinoshita T
    • Journal Title

      Mod Pathol

      Volume: 23 Issue: 4 Pages: 581

    • DOI

      10.1038/modpathol.2010.3

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Grading system for lymph vessel tumor emboli : significant outcome predictor for invasive ductal carcinoma of the breast2010

    • Author(s)
      Hasebe T, Okada N, Iwasaki M, Akashi-Tanaka S, Hojo T, Shibata T, Sasajima Y, Tsuda H, Kinoshita T
    • Journal Title

      Hum Pathol

      Volume: 41 Pages: 706-715

    • URL

      http://dx.doi.org/10.1016/j.humpath.2009.10.015

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] p53 expression in tumor-stromal fibroblasts is closely associated with the nodal metastasis and outcome of patients with invasive ductal carcinoma who received neoadjuvant therapy2010

    • Author(s)
      Hasebe T, Tamura N, Okada N, Hojo T, Akashi-Tanaka S, Shimizu C, Tsuda H, Shibata T, Sasajima Y, Iwasaki M, Kinoshita T
    • Journal Title

      Hum Pathol

      Volume: 41 Issue: 2 Pages: 262

    • DOI

      10.1016/j.humpath.2009.07.021

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] p53 expression in tumor-stromal fibroblasts is closely associated with the nodal metastasis and outcome of patients with invasive ductal carcinoma who received neoadjuvant therapy.2010

    • Author(s)
      Hasebe T, et al.
    • Journal Title

      Hum Pathol

      Volume: 41 Pages: 262-270

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Grading system for lymph vessel tumor emboli : significant outcome predictor for invasive ductal carcinoma of the breast who received neoadjuvant therapy.2010

    • Author(s)
      Hasebe T, et al.
    • Journal Title

      Mod Pathol

      Volume: 23 Pages: 581-592

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Grading system for lymph vessel tumor emboli : significant outcome predictor for invasive ductal carcinoma of the breast.2010

    • Author(s)
      Hasebe T, et al.
    • Journal Title

      Hum Pathol

      Volume: 41 Pages: 706-715

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Metaplastic carcinoma of the breast.2010

    • Author(s)
      Okada N, Hasebe T, et al.
    • Journal Title

      Hum Pathol

      Volume: 41 Pages: 960-970

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] p53 expression in tumor-stromal fibroblasts forming and not forming fibrotic foci in invasive ductal carcinoma of the breast.2010

    • Author(s)
      Hasebe T, et al.
    • Journal Title

      Mod Pathol

      Volume: 23 Pages: 662-672

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] p53 expression in tumor-stromal fibroblasts is closely associated with the nodal metastasis and outcome of patients with invasive ductal carcinoma who received neoadjuvant therapy2010

    • Author(s)
      Hasebe T, et al.
    • Journal Title

      Hum Pathol 41

      Pages: 262-270

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Grading system for lymph vessel tumor emboli : significant outcome predictor for invasive ductal carcinoma of the breast who received neoadjuvant therapy2010

    • Author(s)
      Hasebe T, et al.
    • Journal Title

      Mod Pathol 23

      Pages: 581-592

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Grading system for lymph vessel tumor emboli : significant outcome predictor for invasive ductal carcinoma of the breast2010

    • Author(s)
      Hasebe T, et al.
    • Journal Title

      Hum Pathol (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Metaplastic carcinoma of the breast2010

    • Author(s)
      Okada N, Hasebe T, et al.
    • Journal Title

      Hum Pathol (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] p53 expression in tumor-stromal fibroblasts forming and not forming fibrotic foci in invasive ductal carcinoma of the breast2010

    • Author(s)
      Hasebe T, et al.
    • Journal Title

      Mod Pathol (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tumor histology in lymph vessels and lymph nodes for the accurate prediction of outcome among breast cancer patients treated with neoadjuvant chemotherapy2009

    • Author(s)
      T amura N, Hasebe T, Okada N, Houjoh T, Akashi-Tanaka S, Shimizu C, Shibata T, Sasajima Y, Iwasaki M, Kinoshita T
    • Journal Title

      Cancer Sci

      Volume: 100 Issue: 10 Pages: 1823

    • DOI

      10.1111/j.1349-7006.2009.01264.x

    • NAID

      10027195432

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] P53 expression in tumor stromal fibroblasts is associated with the outcome of patients with invasive ductal carcinoma of the breast2009

    • Author(s)
      Hasebe T, Okada N, Tamura N, Houjoh T, Akashi-Tanaka S, Tsuda H, Shibata T, Sasajima Y, Iwasaki M, Kinoshita T
    • Journal Title

      Cancer Sci

      Volume: 100 Issue: 11 Pages: 2101

    • DOI

      10.1111/j.1349-7006.2009.01307.x

    • NAID

      10027196936

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] p53 expression in tumor-stromal fibroblasts is associated with the outcome of patients with invasive ductal carcinoma of the breast2009

    • Author(s)
      Hasebe T, et al.
    • Journal Title

      Cancer Sci 100

      Pages: 2101-2108

    • NAID

      10027196936

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tumor histology in lymph vessel and lymph nodes for the accurate prediction of outcome among breast cancer patients treated with neoadjuvant chemotherapy2009

    • Author(s)
      Tamura N, Hasebe T, et al.
    • Journal Title

      Cancer Sci 100

      Pages: 1823-1833

    • NAID

      10027195432

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Feasibility study on radiofrequency ablation followed by partial mastectomy for stage I breast cancer patients2009

    • Author(s)
      Imoto S, Hasebe T, et al.
    • Journal Title

      Breast 18

      Pages: 130-134

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 異型腫瘍間質線維芽細胞。術前薬物療法乳癌症例の予後因子としての重要性2011

    • Author(s)
      長谷部孝裕, 他
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2011-10-03
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 異型的な腫瘍間質線維芽細胞の役割2011

    • Author(s)
      長谷部孝裕, 他
    • Organizer
      第100回日本病理学会春季総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2011-04-30
    • Related Report
      2011 Annual Research Report 2011 Final Research Report 2010 Annual Research Report
  • [Presentation] リンパ管腫瘍塞栓組織異型度。術前薬物療法浸潤性乳管癌患者の重要な予後因子2010

    • Author(s)
      長谷部孝裕, 他
    • Organizer
      第18回日本乳癌学会総会
    • Place of Presentation
      ロイトン札幌(札幌市)
    • Related Report
      2011 Final Research Report
  • [Presentation] p53 expression in tumor-stromal fibroblasts forming fibrotic foci in invasive ductal carcinoma of the breast2010

    • Author(s)
      長谷部孝裕, 他
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議センター・リーガロイヤルホテル大阪(大阪市)
    • Related Report
      2011 Final Research Report
  • [Presentation] リンパ管腫瘍塞栓組織異型度。乳癌予後因子としての重要性2010

    • Author(s)
      長谷部孝裕, 他
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      京王プラザ(新宿区)
    • Related Report
      2011 Final Research Report
  • [Presentation] リンパ管内腫瘍及びリンパ節転移腫瘍組織形態像の予後因子としての重要性。術前薬物療法施行乳管癌症例を対象として2009

    • Author(s)
      田村宣子、長谷部孝裕
    • Organizer
      第68回日本癌学会総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2011 Final Research Report
  • [Presentation] 異型腫瘍間質線維芽細胞。術前薬物療法乳癌症例の予後因子としての重要性2009

    • Author(s)
      長谷部孝裕, 他
    • Organizer
      第68回日本癌学会総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2011 Final Research Report
  • [Presentation] 乳癌腫瘍間質線維芽細胞におけるp53蛋白発現の予後因子としての重要性2009

    • Author(s)
      長谷部孝裕
    • Organizer
      第68回 日本癌学会総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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