Basic studies for the immune responses against cancer stem cells of sold tumors

• Project/Area Number: 21590401
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Human pathology
• Research Institution: Sapporo Medical University
• Principal Investigator: TORIGOE Toshihiko 札幌医科大学, 医学部, 准教授 (20301400)
• Co-Investigator(Kenkyū-buntansha): HIROHASHI Yoshihiko 札幌医科大学, 医学部, 助教 (30516901)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 分子病理 / がん幹細胞 / がん抗原 / Cancer stem cell / がんワクチン / CEP55 / DNAJB8 / OR7C1 / Survivin / CTL / ペプチド / がん免疫療法 / 細胞障害性T細胞 / CTLエピトープ / 幹細胞 / がん / 抗原 / 免疫 / T細胞

Research Abstract

We investigated the immunopathological properties of cancer stem cells(CSCs), a small population of cancer cells with stem cell-like phenotype and tumor-initiating capacity. CSCs were collected from various cancer cell lines and analyzed for CSC-specific genes. Three genes were identified as candidates for CSC-specific antigens. We could induce CSC-specific cytotoxic T-cells(CTLs) from cancer patients. Adoptive transfer of the CTLs showed higher tumor suppressive capacity in vivo in a mouse model. Our studies demonstrated a potential of CSC-targeted immunotherapy.

Research Products

• [Journal Article] Heat shock protein 40 family, DNAJB8 is expressed in renal cancer stem-like cell, controls the tumor-initiating ability and can be a potent target of immunotherapy. (2012)
  • Author(s): Nishizawa, S., Mori, T., Hirohashi, Y., Torigoe, T., Tamura, Y., Kamiguchi, K., Takahashi, A., Kanaseki, T., Nakazawa, E., Asanuma, H., Sokolovskaya, A., Morita, R., Yamada, R., Fujii, R., Kondo, T., Hasegawa, T., Hara, I. and Sato, N.
  • Journal Title: Cancer Res Volume: (in press) Issue: 11 Pages: 2844-54
  • DOI: 10.1158/0008-5472.can-11-3062
  • Peer Reviewed
• [Journal Article] Establishment of a monoclonal anti-pan HLA class I antibody suitable for immunostaining of formalin-fixed tissue : Unusually high frequency of down-regulation in breast cancer tissues (2012)
  • Author(s): Torigoe, T., Asanuma, H., Nakazawa. E., Tamura, Y., Hirohashi, Y., Yamamoto, E., Kanaseki, T., Hasegawa, T., Sato, N.
  • Journal Title: Pathol Int Volume: 62 Issue: 5 Pages: 303-8
  • DOI: 10.1111/j.1440-1827.2012.02789.x
  • NAID: 10031185205
  • Peer Reviewed
• [Journal Article] ECRG4 is a negative regulator of caspase-8-mediated apoptosis in human T-leukemia cells (2012)
  • Author(s): Matsuzaki J,Torigoe T,Hirohashi Y, Kamiguchi K,Tamura Y, Tsukahara T,Kubo T, Takahashi A, Nakazawa E,Saka E, Yasuda K,Takahashi S,Sato N.
  • Journal Title: Carcinogenesis Volume: 33 Issue: 5 Pages: 996-1003
  • DOI: 10.1093/carcin/bgs118
  • Peer Reviewed
• [Journal Article] Novel oligomannose liposome-DNA complex DNA vaccination efficiently evokes anti-HPV E6 and E7 CTL responses (2012)
  • Author(s): Mizuuchi M, Hirohashi Y, Torigoe T, Takafumi K, Yasuda K, Saito T, Sato N
  • Journal Title: Exp Mol Pathol. Volume: 92 Issue: 1 Pages: 185-190
  • DOI: 10.1016/j.yexmp.2011.10.002
  • Peer Reviewed
• [Journal Article] Efficiency of G2/M-related tumor-associated antigen-targeting cancer immunotherapy depends on antigen expression in the cancer stem-like population (2012)
  • Author(s): Mori T, Nishizawa S, Hirohashi Y, Torigoe T, Tamura Y, Takahashi A, Kochin V, Fujii R, Toru K, Greene MI, Hara I, Sato N
  • Journal Title: Exp Mol Pathol Volume: 92 Pages: 27-32
  • URL: http://dx.doi.org/10.1016/j.yexmp.2011.09.016
  • Peer Reviewed
• [Journal Article] Novel oligomannose liposome-DNA complex DNA vaccination efficiently evokes anti-HPV E6 and E7 CTL responses (2012)
  • Author(s): Mizuuchi M
  • Journal Title: Exp Mol Pathol Volume: 92(1) Pages: 185-190
  • Peer Reviewed
• [Journal Article] Efficiency of G2/M-related tumor-associated antigen-targeting cancer immunotherapy depends on antigen expression in the cancer stem-like population (2012)
  • Author(s): Takashi Mori, Satoshi Nishizawa, Yoshihiko Hirohashi, Toshihiko Torigoe, Yasuaki Tamura, Akari Takahashi, Vitaly Kochin, Reona Fujii, Kondo Toru, Mark I. Greene, Isao Hara, Noriyuki Sato
  • Journal Title: Experimental and Molecular Pathology Volume: 92 Issue: 1 Pages: 27-32
  • DOI: 10.1016/j.yexmp.2011.09.016
  • Peer Reviewed
• [Journal Article] SOX2 is expressed in stem-like cells of human lung adenocarcinoma and augments the tumor-initiating potential (2011)
  • Author(s): Nakatsugawa, M., Takahashi, A., Hirohashi, Y., Torigoe, T., Inoda, S., Asanuma, H., Tamura, Y., Hasegawa, T., Takahashi, H., and Sato, N.
  • Journal Title: Lab Invest. Volume: 91 Issue: 12 Pages: 1796-1804
  • DOI: 10.1038/labinvest.2011.140
  • Peer Reviewed
• [Journal Article] Tumor associated dendritic cells : molecular mechanisms to suppress anti-tumor immunity (2011)
  • Author(s): Hirohashi, Y. and Sato, N.
  • Journal Title: Immunotherapy Volume: 3 Issue: 8 Pages: 945-947
  • DOI: 10.2217/imt.11.94
  • Peer Reviewed
• [Journal Article] Tumor-Produced Secreted Form of Binding of Immunoglobulin Protein Elicits Antigen-Specific Tumor Immunity. (2011)
  • Author(s): Tamura Y, Hirohashi Y, Kutomi G, Nakanishi K, Kamiguchi K, Torigoe T, Sato N.
  • Journal Title: J. Immunol Volume: 186 Issue: 7 Pages: 4325-4330
  • DOI: 10.4049/jimmunol.1004048
  • Peer Reviewed
• [Journal Article] Extracellular heat shock protein 90 plays a role in translocating chaperoned antigen from endosome to proteasome for generating antigenic peptide to be cross-presented by dendritic cells. (2011)
  • Author(s): Oura, J., Tamura, Y., Kamiguchi, K., Kutomi, G., Sahara, H., Torigoe, T., Himi, T., and Sato, N.
  • Journal Title: Int. Immunol Volume: 23 Issue: 4 Pages: 223-237
  • DOI: 10.1093/intimm/dxq475
  • Peer Reviewed
• [Journal Article] Autologous CTL response against cancer stem-like cells/cancer-initiating cells of bone malignant fibrous histiocytoma (2011)
  • Author(s): Kano, M., Tsukahara, T., Emori, M., Murase, M., Torigoe, T., Kawaguchi, S., Wada, T., Yamashita, T., Sato, N.
  • Journal Title: Cancer Sci Volume: 102 Issue: 8 Pages: 1443-1137
  • DOI: 10.1111/j.1349-7006.2011.01962.x
  • NAID: 10030241866
  • Peer Reviewed
• [Journal Article] Immunogenic enhancement and clinical effect by type-I interferon of anti-apoptotic protein, survivin-derived peptide vaccine, in advanced colorectal cancer patients (2011)
  • Author(s): Kameshima, H., Tsuruma, T., Torigoe, T., Takahashi, A., Hirohashi, Y., Tamura, Y., Tsukahara, T., Ichimiya, S., Kanaseki, T., Iwayama, Y., Sato, N., Hirata, K.
  • Journal Title: Cancer Sci Volume: 102 Issue: 6 Pages: 1181-1187
  • DOI: 10.1111/j.1349-7006.2011.01918.x
  • NAID: 10029294487
  • Peer Reviewed
• [Journal Article] Comparison of speedy PCR-ssp method and serological typing of hla-a24 for Japanese cancer patients. (2011)
  • Author(s): Nakatsugawa M, Hirohashi Y, Torigoe T, Inoda S, Kiriyama K, Tamura Y, Sato E, Takahashi H, Sato N.
  • Journal Title: J Immunoassay Immunochem Volume: 32 Issue: 2 Pages: 93-102
  • DOI: 10.1080/15321819.2010.543219
  • Peer Reviewed
• [Journal Article] Cytotixic T lymphocytes efficiently recognize human colon cancer stem-like cells (2011)
  • Author(s): Inoda, S., Hirohashi, Y., Torigoe, T., Takahashi, A., Morita, R., Nakatsugawa, M., Nishizawa, S., Tamura, Y., Tsuruma, T., Terui, T., Ishitani, K., Hirata, K. and Sato, N.
  • Journal Title: Am. J. Pathol. Volume: 178 Issue: 4 Pages: 1805-1813
  • DOI: 10.1016/j.ajpath.2011.01.004
  • Peer Reviewed
• [Journal Article] Phase I clinical trial of survivin-derived peptide vaccine therapy for patients with advanced or recurrent oral cancer (2011)
  • Author(s): Miyazaki A, Kobayashi J, Torigoe T, Hirohashi Y, Yamamoto T, Yamaguchi A, Asanuma H, Takahashi A, Michifuri Y, Nakamori K, Nagai I, Sato N, Hiratsuka H.
  • Journal Title: Cancer Sci Volume: 102 Issue: 2 Pages: 324-329
  • DOI: 10.1111/j.1349-7006.2010.01789.x
  • NAID: 10029289826
  • Peer Reviewed
• [Journal Article] The feasibility of Cep55/c10orf3 derived peptide vaccine therapy for colorectal carcinoma (2011)
  • Author(s): Inoda S, Morita R, Hirohashi Y, Torigoe T, Asanuma H, Nakazawa E, Nakatsugawa M, Tamura Y, Kamiguchi K, Tsuruma T, Terui T, Ishitani K, Hashino S, Wang Q, Greene MI, Hasegawa T, Hirata K, Asaka M, Sato N.
  • Journal Title: Exp. Mol. Pathol. Volume: 90 Issue: 1 Pages: 55-60
  • DOI: 10.1016/j.yexmp.2010.10.001
  • Peer Reviewed
• [Journal Article] Autoantibody against hypoxia-inducible factor prolyl hydroxylase-3 is a potential serological marker for renal cell carcinoma (2011)
  • Author(s): Tanaka, T., Kitamura, H., Torigoe, T., Hirohashi, Y., Masumori, N., Sato, N. and Tsukamoto, T.
  • Journal Title: J. Cancer Res. Clin. Oncol Volume: 137 Issue: 5 Pages: 789-794
  • DOI: 10.1007/s00432-010-0940-6
  • Peer Reviewed
• [Journal Article] Identification of an HLA-A*0201-restricted cytotoxic T lymphocyte epitope from the lung carcinoma antigen, Lengsin (2011)
  • Author(s): Nakatsugawa M
  • Journal Title: Int J Oncol Volume: 39(4) Pages: 1041-1049
  • DOI: 10.3892/ijo.2011.1089
  • Peer Reviewed
• [Journal Article] Cytotoxic T lymphocytes efficiently recognize human colon cancer stem-like cells (2011)
  • Author(s): Inoda S
  • Journal Title: Am J Pathol Volume: 178(4) Pages: 1805-1813
  • Peer Reviewed
• [Journal Article] Tumor-produced secreted form of binding of immunoglobulin protein elicits antigen-specific tumor immunity (2011)
  • Author(s): Tamura Y
  • Journal Title: J Immunol Volume: 186(7) Pages: 4325-4330
  • Peer Reviewed
• [Journal Article] Autoantibody against hypoxia-inducible factor prolyl hydroxylase-3 is a potential serological marker for renal cell carcinoma (2011)
  • Author(s): Tanaka T
  • Journal Title: J Cancer Res Clin Oncol Volume: 137(5) Pages: 789-794
  • Peer Reviewed
• [Journal Article] A phase I clinical trial of survivin-derived peptide vaccine therapy in HLA-A24-positive patients with oral cancer. (2011)
  • Author(s): Miyazaki A, Torigoe T, et al.
  • Journal Title: Cancer Sci. Volume: 102 Pages: 324-9
  • Peer Reviewed
• [Journal Article] Spatiotemporal regulation of heat shock protein 90-chaperoned self-DNA and CpG-oligodeoxynucleotide for type I IFN induction via targeting to static early endosome (2010)
  • Author(s): Okuya, K., Tamura, Y., Saito, K., Kutomi, G., Torigoe, T., Hirata, K., Sato, N.
  • Journal Title: J. Immunol Volume: 184 Issue: 12 Pages: 7092-7099
  • DOI: 10.4049/jimmunol.1000490
  • Peer Reviewed
• [Journal Article] Immune response against tumor antigens expressed on human cancer stem-like cells/tumor-initiating cells (2010)
  • Author(s): Hirohashi, Y., Torigoe, T., Inoda, S., Takahashi, A., Morita, R., Nishizawa, S., Tamura, Y., Suzuki, H., Yoyota, M. Sato, N.
  • Journal Title: Immunotherapy Volume: 2 Pages: 201-211
  • Peer Reviewed
• [Journal Article] Extracellular heat shock protein 90 (Hsp90) directs self-DNA to static early endosome-resident TLR-9, leading to type I interferon production. (2010)
  • Author(s): Okuya, K., Torigoe, T., et al.
  • Journal Title: J.Immunol. Volume: 184 Pages: 7092-7099
  • Peer Reviewed
• [Journal Article] Establishment of shared antigen reactive cytotoxic T lymphocyte using co-stimulatory molecule introduced autologous cancer cells. Exp Mol Pathol. (2010)
  • Author(s): Hirohashi, Y., Torigoe, T., et al.
  • Journal Title: Exp Mol Pathol. Volume: 88 Pages: 128-132
  • Peer Reviewed
• [Journal Article] Autoantibody against hypoxia-inducible factor prolyl hydroxylase-3 is a potential marker for renal cell carcinoma. (2010)
  • Author(s): Tanaka T, Torigoe T, et al.
  • Journal Title: J Cancer Res Clin Oncol. Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] The feasibility of Cep55/c10orf3 derived peptide vaccine therapy for colorectal carcinoma. (2010)
  • Author(s): Inoda S, Torigoe T, et al.
  • Journal Title: Exp Mol Pathol. Volume: 90 Pages: 55-60
  • Peer Reviewed
• [Journal Article] Immune response against tumor antigens expressed on human cancer-stem cells/tumor-initiating cells. (2010)
  • Author(s): Hirohashi Y., Torigoe T., et al.
  • Journal Title: Immunotherapy Volume: 2 Pages: 201-211
  • Peer Reviewed
• [Journal Article] Immune response against tumor antigens expressed on human cancer-stem cells/tumor-initiating cells (2010)
  • Author(s): 廣橋良彦, et al
  • Journal Title: Immunotherapy 2 Pages: 201-211
  • Peer Reviewed
• [Journal Article] Establishment of shared antigen reactive cytotoxic T lymphocyte using co-stimulatory molecule introduced autologous cancer cells (2010)
  • Author(s): 廣橋良彦, et al
  • Journal Title: Exp Mol Pathol. 88 Pages: 128-132
  • Peer Reviewed
• [Journal Article] Side population cells have the characteristics of cancer stem-like cells/cancer-initiating cells in bone sarcomas (2009)
  • Author(s): Murase, M., Kano, M., Tsukahara, T., Takahashi, A., Torigoe, T., Kawaguchi, S., Kimura, S., Wada, T., Uchihashi, Y., Kondo, T., Yamashita, T. and Sato N.
  • Journal Title: Brit. J. Cancer Volume: 101 Issue: 8 Pages: 1425-1432
  • DOI: 10.1038/sj.bjc.6605330
  • Peer Reviewed
• [Journal Article] Targeting to static endosome is required for efficient cross-presentation of endoplasmic reticulum-resident oxygen regulated protein 150(ORP150)-peptide complexes (2009)
  • Author(s): Kutomi, G., Tamura, Y., Okuya, K., Hirohashi, Y., Kamiguchi, K., Saito, K., Torigoe, T., Ogawa, S., Hirata, K. and Sato, N.
  • Journal Title: J. Immunol Volume: 183 Issue: 9 Pages: 5861-5869
  • DOI: 10.4049/jimmunol.0803768
  • Peer Reviewed
• [Journal Article] Heat shock proteins and immunity : application of hyperthermia for immunomodulation (2009)
  • Author(s): Torigoe, T., Tamura, Y., Sato, N.
  • Journal Title: Int. J. Hyperthermia Volume: 25 Issue: 8 Pages: 610-616
  • DOI: 10.3109/02656730903315831
  • Peer Reviewed
• [Journal Article] Aberrant expression and potency as a cancer immunotherapy target of alpha-methylacyl-coenzyme A racemase in prostate cancer (2009)
  • Author(s): Honma, I., Torigoe, T., Hirohashi, Y., Kitamura, H., Sato, E., Masumori, N., Tamura, Y., Tsukamoto, T., Sato, N.
  • Journal Title: J. Transl. Med Volume: 7 Issue: 1 Pages: 103-110
  • DOI: 10.1186/1479-5876-7-103
  • Peer Reviewed
• [Journal Article] Establishment of shared antigen reactive cytotixic T lymphocytes using co-stimulatory molecule introduced autologous cancer cells (2009)
  • Author(s): Hirohashi, Y., Torigoe, T., Hirai, I., Tamura, Y., Nakatsugawa, M., Inoue, Y., Kanaseki, T., Kamiguchi, K., Ikeda, H., Sasaki, A., Yamanaka, N. and Sato, N.
  • Journal Title: Exp. Mol. Pathol.
  • URL: http://dx.doi.org/10.1016/j.yexmp.2009.09.021
  • Peer Reviewed
• [Journal Article] Human leukocyte antigen class I down-regulation in muscle-invasive bladder cancer : Its association with clinical characteristics and survival after cystectomy (2009)
  • Author(s): Homma, I., Kitamura, H., Torigoe, T., Tanaka, T., Sato, E., Hirohashi, Y., Masumori, N., Sato, N. and Tsukamoto, T.
  • Journal Title: Cancer Sci Volume: 100 Issue: 12 Pages: 2331-2334
  • DOI: 10.1111/j.1349-7006.2009.01329.x
  • NAID: 10027198144
  • Peer Reviewed
• [Journal Article] A novel spliced form of a lens protein as a novel lung cancer antigen (2009)
  • Author(s): Nakatsugawa, M. Hirohashi, Y., Torigoe, T., Asanuma, H., Takahashi, A., Inosa, S., Kiriyama, K., Nakazawa, E., Harada, K., Takasi, H., Tamura, Y., Kamiguchi, K., Shijubo, N., Honda, R., Nomura, N., Hasegawa, T., Takahashi, H. and Sato, N.
  • Journal Title: Cancer Sci Volume: 100 Issue: 8 Pages: 1485-1493
  • DOI: 10.1111/j.1349-7006.2009.01187.x
  • Peer Reviewed
• [Journal Article] HLA-A 0201-restricted CTL epitope of a novel osteosarcoma antigen, papillomavirus binding factor (2009)
  • Author(s): Tsukahara, T., Kawaguchi, S., Torigoe, T., Takahashi, A., Murase, M., Kano, M., Wada, T., Kaya, M., Nagoya, S., Yamashita, T. and Sato, N.
  • Journal Title: J. Transl. Med Volume: 7 Issue: 1 Pages: 44-51
  • DOI: 10.1186/1479-5876-7-44
  • Peer Reviewed
• [Journal Article] Molecular pathologic approaches to human tumor immunology (2009)
  • Author(s): Sato, N., Hirohashi, Y., Tsukahara, T., Kikuchi, T., Sahara, H., Kamiguchi, K., Ichimiya, S., Tamura, H. and Torigoe, T.
  • Journal Title: Pathol. Int Volume: 59 Issue: 4 Pages: 205-217
  • DOI: 10.1111/j.1440-1827.2009.02353.x
  • NAID: 10027379604
  • Peer Reviewed
• [Journal Article] Polyamine compound deoxyspergualin inhibits heat shock protein-induced activation of immature dendritic cells (2009)
  • Author(s): Sugawara, A., Torigoe, T., Tamura, Y., Kamiguchi, K., Nemoto, K., Oguro, H., Sato, N.
  • Journal Title: Cell Stress Chaperone Volume: 14 Issue: 2 Pages: 133-139
  • DOI: 10.1007/s12192-008-0064-y
  • Peer Reviewed
• [Journal Article] The functioning antigens ; beyond just as the immunologic targets (2009)
  • Author(s): Hirohashi, Y., Torigoe, T., Inoda, S., Kobayashi, J., Nakatsugawa, M., Mori, T., Hara, I. and Sato, N.
  • Journal Title: Cancer Sci Volume: 100 Issue: 5 Pages: 798-806
  • DOI: 10.1111/j.1349-7006.2009.01137.x
  • NAID: 10025145179
  • Peer Reviewed
• [Journal Article] Cep55/c10orf3, a tumor antigen derived from a centrosome residing protein in breast carcinoma (2009)
  • Author(s): Inoda, S., Hirohashi, Y., Torigoe, T., Nakatsugawa, M., Kiriyama, K., Harada, K., Takasu, H., Tamura, Y., Kamiguchi, K., Asanuma, H., Tsuruma, T., Terui, T., Ishitani, K., Ohmura, T., Hasegawa, T., Hirata, K. and Sato, N.
  • Journal Title: J. Immunother. Volume: 32 Pages: 474-485
  • Peer Reviewed
• [Journal Article] Phase I clinical study of anti-apoptosis protein survivin-derived peptide vaccination for patients with advanced or recurrent urothelial cancer (2009)
  • Author(s): Honma, I., Kitamura, H., Torigoe, A. Takahashi, T., Tanaka, T., Sato, E., Hirohashi, Y., Masumori, N., Tsukamoto, T., Sato, N.
  • Journal Title: Cancer Immunol. Immunother Volume: 58 Issue: 11 Pages: 1801-1807
  • DOI: 10.1007/s00262-009-0691-x
  • Peer Reviewed
• [Journal Article] Clonal diversity of cytotoxic T lymphocytes that recognize autologous oral squamous cell carcinoma (2009)
  • Author(s): Kobayashi, J., Torigoe, T., Hirohashi, Y., Tamura, Y., Kamiguchi, K., Miyazaki, A., Yamaguchi, A., Yamamoto, T., Hariu, H., Hiratsuka, H. and Sato, N.
  • Journal Title: Hum Immunol. Volume: 70 Pages: 89-95
  • URL: http://dx.doi.org/10.1016/j.humimm.2008.11.004
  • Peer Reviewed
• [Journal Article] Comparative study on the immunogenicity between an HLA-A24-restricted cytotoxic T-cell epitope derived from surviving and that from its splice variant surviving-2B in oral cancer patients (2009)
  • Author(s): Kobayashi, J., Torigoe, T., Hirohashi, Y., Idenoue, S., Miyazaki, A., Yamaguchi, A., Hiratsuka, H. and Sato, N.
  • Journal Title: J. Transl. Med Volume: 7 Issue: 1 Pages: 1-11
  • DOI: 10.1186/1479-5876-7-1
  • Peer Reviewed
• [Journal Article] Immunosuppressive effect on T cell activation by interleukin-16 and interleukin 10 cDNA-double-transfected human squamous cell line (2009)
  • Author(s): Matsumoto, Y., Fujita, T., Hirai, I., Sahara, H., Torigoe, T., Ezoe, K., Saito, Y., Cruikshank, W. W., Yotsuyanagi, T. and Sato, N.
  • Journal Title: Burns Volume: 35 Pages: 383-389
  • URL: http://dx.doi.org/10.1016/j.burns.2008.06.017
  • Peer Reviewed
• [Journal Article] Side population cells have the characteristics of cancer stem-like cells/cancer-initiating cells in bone sarcomas (2009)
  • Author(s): Murase, M., et al
  • Journal Title: Br J Cancer. 101 Pages: 1425-1432
  • Peer Reviewed
• [Journal Article] Aberrant expression and potency as a cancer immunotherapy target of alpha-methylacyl-coenzyme A racemase in prostate cancer (2009)
  • Author(s): Honma, I., et al
  • Journal Title: J Transl.Med. 7 Pages: 103-113
  • Peer Reviewed
• [Journal Article] Comparative study on the immunogenicity between an HLA-A24-restricted cytotoxic T-cell epitope derived from surviving and that from its splice variant surviving-2B in oral cancer patients (2009)
  • Author(s): Kobayashi, J., et al
  • Journal Title: J.Transl.Med. 7 Pages: 1-11
  • Peer Reviewed
• [Journal Article] HLA-A^*0201-restricted clonal CTL epitope of a novel osteosarcoma antigen, papil lomavirus binding factor (2009)
  • Author(s): Tsukahara, T., et al
  • Journal Title: J.Transl.Med. 12;7 Pages: 44-44
  • Peer Reviewed
• [Journal Article] Phase Iclinical study of anti-apoptosis protein survivin-derived peptidevaccination for patients with advanced or recurrent urothelial cancer (2009)
  • Author(s): Honma, I., et al
  • Journal Title: Cancer Immunol.Immunother. 58 Pages: 1801-1807
  • Peer Reviewed
• [Journal Article] Novel spliced form of a lens protein as a novel lung cancer antigen, Lengsin splicing variant 4 (2009)
  • Author(s): Nakatsugawa, M., et al
  • Journal Title: Cancer Sci. 100 Pages: 1485-1493
  • Peer Reviewed
• [Journal Article] Cep55/c10orf3, a tumor antigen derived from a centrosome residing protein in breast carcinoma (2009)
  • Author(s): Inoda, S., et al
  • Journal Title: J Immunother. 32 Pages: 474-485
  • Peer Reviewed
• [Journal Article] Human leukocyte antigen class I down-regulation in muscle-invasive bladder cancer : Its association with clinical characteristics and survival after cystectomy (2009)
  • Author(s): Homma, I., et al
  • Journal Title: Cancer Sci. 100 Pages: 2331-2334
  • Peer Reviewed
• [Journal Article] The functioning antigens ; beyond just as the immunologic targets (2009)
  • Author(s): 廣橋良彦, et al
  • Journal Title: Cancer Sci. 100 Pages: 798-806
  • NAID: 10025145179
  • Peer Reviewed
• [Journal Article] Molecular pathologic approaches to human tumor immunology (2009)
  • Author(s): Sato, N., et al
  • Journal Title: Pathol.Int. 59 Pages: 205-217
  • Peer Reviewed
• [Journal Article] がん幹細胞抗原の検索とがんワクチンへの応用 (2009)
  • Author(s): 廣橋良彦, 他
  • Journal Title: 最新医学 64 Pages: 27-36
• [Journal Article] がんの免疫逃避メカニズムとその制御 (2009)
  • Author(s): 守田玲菜, 他
  • Journal Title: 臨床血液 50 Pages: 375-380
• [Journal Article] Scythe/BAT3 regulates apoptotic cell death induced by papillomavirus binding factor in human osteosarcoma (2008)
  • Author(s): Tsukahara, T., Kimura, S., Ichimiya, S., Torigoe, T., Kawaguchi, S., Wada, T., Yamashita, T., Sato, N.
  • Journal Title: Cancer Sci Volume: 100 Issue: 1 Pages: 47-53
  • DOI: 10.1111/j.1349-7006.2008.00991.x
  • NAID: 10025141244
  • Peer Reviewed
• [Journal Article] DNA methyltransferase 1 is essential for maintenance of human colon cancer stem-like cells
  • Author(s): Morita, R., Hirohashi, Y., Torigoe, T., Takahashi, A., Saka, E., Asanuma, H., Suzuki, H., Tamura, H., Nakazawa, E., Ito-Inoda, S., Hashino, S., Hasegawa, T., Tokino, T., Toyota, M., Asaka, M. and Sato, N.
  • Journal Title: Am J. Pathol. Volume: (in press)
  • Peer Reviewed
• [Journal Article] Heat shock protein 90 governs self-nucleic acid recognition by Toll-like receptors
  • Author(s): Saito, K., Tamura, Y., Kukita, K., Kutomi, G., Okuya, K., Asanuma, H., Torigoe, T., Hirata, K., Sato, N.
  • Journal Title: Nature
• [Presentation] がん幹細胞の免疫病理学的特性の解析:がん幹細胞標的治療へ向けて (2011)
  • Author(s): 鳥越俊彦、廣橋良彦、佐藤昇志
  • Organizer: バイオセラピィ学会シンポジウム
  • Place of Presentation: 和歌山
  • Year and Date: 2011-12-01
• [Presentation] がん幹細胞の免疫病理学的特性の解析:がん幹細胞標的治療へ向けて (2011)
  • Author(s): 鳥越俊彦
  • Organizer: バイオセラピー学会シンポジウム
  • Place of Presentation: 和歌山(招待講演)
  • Year and Date: 2011-12-01
• [Presentation] がん幹細胞を標的とする免疫療法 (2011)
  • Author(s): 廣橋良彦、鳥越俊彦、井野田智子、守田玲菜、高橋あかり、中津川宗秀、道振義貴、佐藤昇志
  • Organizer: 第70回日本癌学会学術総会、シンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-03
• [Presentation] がん幹細胞の免疫学的特性とワクチン開発 (2011)
  • Author(s): 鳥越俊彦、廣橋良彦、田村保明、佐藤昇志
  • Organizer: がん免疫学会シンポジウム
  • Place of Presentation: 大阪
  • Year and Date: 2011-06-30
• [Presentation] がん幹細胞の免疫学的特性とワクチン開発 (2011)
  • Author(s): 鳥越俊彦
  • Organizer: がん免疫学会シンポジウム
  • Place of Presentation: 大阪(招待講演)
  • Year and Date: 2011-06-30
• [Presentation] 難治がんに対するペプチドワクチン療法:現状と課題 (2011)
  • Author(s): 鳥越俊彦
  • Organizer: 北海道癌談話会シンポジウム
  • Place of Presentation: 札幌(招待講演)
  • Year and Date: 2011-06-25
• [Presentation] がん組織の微小環境と免疫 (2011)
  • Author(s): 鳥越俊彦
  • Organizer: 第100回日本病理学会学術総会、シンポジウム
  • Place of Presentation: 横浜
  • Year and Date: 2011-04-28
• [Presentation] がん幹細胞の免疫学的特性とワクチン開発 (2011)
  • Author(s): 鳥越俊彦、廣橋良彦、佐藤昇志
  • Organizer: 第13回癌治療増感研究シンポジウム
  • Place of Presentation: 奈良
  • Year and Date: 2011-02-11
• [Presentation] 次世代がんワクチン:がん幹細胞標的ペプチドワクチンの実用化研究 (2011)
  • Author(s): 鳥越俊彦、廣橋良彦、守田玲菜、田村保明、平田公一、佐藤昇志
  • Organizer: 日本癌治療学会シンポジウム
  • Place of Presentation: 名古屋
• [Presentation] Exploration of pathological properties of cancer stem cells(CSCs) (2011)
  • Author(s): Toshihiko Torigoe
  • Organizer: CSC-specific mitochondrial protein and heat shock protein 5th Biennial Meeting of Society for Free Radical Research-Asia
  • Place of Presentation: Kagoshima, Japan
• [Presentation] Stress Response Genes Expressed in Cancer Stem Cells-potent molecular targets for cancer therapy- (2011)
  • Author(s): Toshihiko Torigoe, Hirohashi Yoshihiko, Yasuaki Tamura, Noriyuki Sato
  • Organizer: The 5^<th> International Congress on Stress Responses in Biology and Medicine
  • Place of Presentation: Quebec City, Canada.
• [Presentation] 次世代がんワクチン:がん幹細胞標的ペプチドワクチンの実用化研究 (2011)
  • Author(s): 鳥越俊彦
  • Organizer: 日本癌治療学会シンポジウム
  • Place of Presentation: 名古屋(招待講演)
• [Presentation] Exploration of pathological properties of cancer stem cells (CSCs) : CSC-specific mitochondrial protein and heat shock protein (2011)
  • Author(s): Toshihiko Torigoe
  • Organizer: The 5th Biennial Meeting of Society for Free Radical Research-Asia
  • Place of Presentation: Kagoshima, Japan(招待講演)
• [Presentation] Stress Response Genes Expressed in Cancer Stem Cells-potent molecular targets for cancer therapy- (2011)
  • Author(s): Toshihiko Torigoe
  • Organizer: The 5^<th> International Congress on Stress Resp onses in Biology and Medicine
  • Place of Presentation: Quebec City, Canada(招待講演)
• [Presentation] Immune responses against cancer stem cells (2010)
  • Author(s): Toshihiko Torigoe, Yoshihiko Hirohashi, Noriyuki Sato
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-22
• [Presentation] Immune responses against cancer stem cells. (2010)
  • Author(s): Toshihiko Torigoe
  • Organizer: 第69回日本癌学会学術総会、シンポジウム
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-22
• [Presentation] Cancer initiating cellを標的とした免疫療法の基礎的研究 (2010)
  • Author(s): 鳥越俊彦、廣橋良彦、佐藤昇志
  • Organizer: 日本がん免疫学会、シンポジウム
  • Place of Presentation: 熊本
  • Year and Date: 2010-07-22
• [Presentation] 乳がんに対する免疫療法研究最前線-がん幹細胞抗原と免疫逃避の制御- (2010)
  • Author(s): 鳥越俊彦
  • Organizer: 乳がん学会総会、シンポジウム
  • Place of Presentation: 札幌
  • Year and Date: 2010-06-25
• [Presentation] Development of Cancer Stem Cell Vaccine (2010)
  • Author(s): Toshihiko Torigoe
  • Organizer: The 25^<th> International Society for Biological Therapy of Cancer
  • Place of Presentation: Washington DC, USA
• [Presentation] A novel DNAJ family protein is a cancer initiating cell antigen.-A potent molecular target for cancer immunotherapy- (2010)
  • Author(s): Toshihiko Torigoe, Yoshihiko Hirohashi, Satoshi Nishizawa, Akari Takahashi, Hiroko Asanuma, Munehide Nakatsugawa, Kenjiro Kamiguchi, Alisa A. Sokolovskaya, Noriyuki Sato.
  • Organizer: The 8^<th> International Workshop on the Molecular Biology of Stress Responses
  • Place of Presentation: Seorak Mt., Korea
• [Presentation] Development of Cancer Stem Cell Vaccine (2010)
  • Author(s): Toshihiko Torigoe
  • Organizer: 8^<th> AACR/JCA Joint Conference : Cancer Genomics, Epigenomics, and the Development of Novel Therapeutics
  • Place of Presentation: Waikoloa, Hawaii, USA
• [Presentation] A novel DNAJ family protein is a cancer initiating cell antigen. -A potent molecular target for cancer immunotherapy- (2010)
  • Author(s): Toshihika Torigoe
  • Organizer: The 8^<th> International Workshop on the Molecular Biology of Stress Responses
  • Place of Presentation: Seorak Mt., Korea
• [Presentation] MHC class I expression is down-regulated through epithelial-mesenchymal transition of breast cancer. (2010)
  • Author(s): T.Torigoe
  • Organizer: 14^<th> International Congress on Immunology
  • Place of Presentation: Kobe, Japan
• [Presentation] Development of Cancer Stem Cell Vaccine. (2010)
  • Author(s): Toshihiko Torigoe
  • Organizer: The 25^<th> International Society for Biological Therapy of Cancer.
  • Place of Presentation: Washington DC, USA
• [Presentation] Exploration of molecular markers for cancer stem cells and the possible application to tageting therapy. 8th AACR/JCA Joint Conference (2010)
  • Author(s): Torigoe, T.
  • Organizer: Cancer Genomics, Epigenomics, and the Development of Novel Therapeutics
  • Place of Presentation: Hawaii
• [Presentation] ペプチドがんワクチン開発のトランスレーショナルリサーチ～ますます重要性を帯びる基礎医学研究基盤～ (2009)
  • Author(s): 鳥越俊彦
  • Organizer: 第6回日本免疫治療学研究会
  • Place of Presentation: 東京
  • Year and Date: 2009-02-21
• [Presentation] ヒト医療におけるがんワクチン療法の現状と課題 (2009)
  • Author(s): 鳥越俊彦
  • Organizer: 日本獣医臨床病理学会
  • Place of Presentation: 東京
  • Year and Date: 2009-02-15
• [Presentation] がん幹細胞抗原の解析とがんワクチン臨床試験 (2009)
  • Author(s): 鳥越俊彦
  • Organizer: From Bench to Bedside and Lesson from the Bedside埼玉血液懇談会
  • Place of Presentation: 埼玉
  • Year and Date: 2009-01-14
• [Presentation] 自然免疫内因性リガントとしてのストレス蛋白質による自己免疫疾患病態制御 (2009)
  • Author(s): 田村保明、鳥越俊彦、佐藤昇志
  • Organizer: 第37回日本臨床免疫学会総会
  • Place of Presentation: 東京
• [Presentation] Can immune system recognize and attack cancer stem cells? (2009)
  • Author(s): Torigoe, T.
  • Organizer: Cancer Stem Cell Symposium
  • Place of Presentation: Seoul, Korea
• [Presentation] Apoptosis regulator protein PBF is an immunological target for patients with osteosarcoma (2009)
  • Author(s): Tsukahara, T., Kawaguchi, S., Kano, M., Wada, T., Yamashita, T., Torigoe, T., Takahashi, A. and Sato, N.
  • Organizer: 24^<th> Annual Meeting of International Society for Biological Therapy of Cancer
  • Place of Presentation: Washington DC, USA
• [Presentation] Identification of cancer stem cell antigens revealed unique characteristics of triple negative breast cancer (2009)
  • Author(s): Torigoe, T., Hirohashi, Y., Takahashi, A., Asanuma, H., Nakatsugawa, M., Inoda, S., Sato, N.
  • Organizer: 14th World Congress on Advances in Oncology and 12th International Symposium on Molecular Medicine
  • Place of Presentation: Loutraki, Greece
• [Presentation] Development of HSP90-based cancer vaccine and its mechanism (2009)
  • Author(s): Tamura, Y., Okuya, K., Saito, K., Torigoe, T., Sato, N.
  • Organizer: The 4th International Congress on Stress Responses in Biology and Medicine/The 4th Annual Meeting of the Biomedical Society for Stress Response
  • Place of Presentation: Sapporo
• [Presentation] Cancer Stem Cell Genes-potent molecular targets for cancer stem cell therapy- (2009)
  • Author(s): Torigoe, T.
  • Organizer: The 4th International Congress on Stress Responses in Biology and Medicine/The 4th Annual Meeting of the Biomedical Society for Stress Response
  • Place of Presentation: Sapporo
• [Presentation] Functional analysis of novel mitochondrial proteins (2009)
  • Author(s): Torigoe, T.
  • Organizer: ECRG4 and SMCP
  • Place of Presentation: Free Radical School in Jap an Minami Uonuma, Niigata
• [Presentation] ヒト癌幹細胞に対する免疫応答 (2009)
  • Author(s): 廣橋良彦、鳥越俊彦、佐藤昇志
  • Organizer: 免疫アジュバント研究会
  • Place of Presentation: 洞爺
• [Presentation] Isolation of Cancer Stem Cells and Identification of Cancer Stem Cell Markers (2009)
  • Author(s): Torigoe, T.
  • Organizer: Abbott Diagnostics Division Centers of Excellence Conference Paris
  • Place of Presentation: France
• [Presentation] Can immune system recognize and attack cancer stem cells? (2009)
  • Author(s): Torigoe, T.
  • Organizer: Cancer Stem Cell Symposium
  • Place of Presentation: Korea
• [Book] がん免疫療法の標的抗原、がん免疫療法-実用化へのチャレンジ- (2010)
  • Author(s): 守田玲菜、廣橋良彦、鳥越俊彦、佐藤昇志
  • Publisher: シーエムシー出版
• [Book] Cancer, Immunology and Photonics S cience. Optical Devices and Systems, Biomedical and Green Technologies. (2010)
  • Author(s): Noriyuki Sato, Yoshihiko Hirohashi, Tomohide Tsukahara, Shingo Ichimiya, Yasuaki Tamura and Toshihiko Torigoe
• [Book] がん免疫療法の標的抗原、がん免疫療法-実用化へのチャレンジ- (2010)
  • Author(s): 守田玲菜、鳥越俊彦, et al.
  • Publisher: シーエムシー出版
• [Book] バイオ医薬の開発技術とシーズ.第30章がんペプチド免疫治療 (2009)
  • Author(s): 佐藤昇志、廣橋良彦、塚原智英、田村保明、一宮慎吾、鳥越俊彦
  • Publisher: シーエムシー出版
• [Patent(Industrial Property Rights)] ケロイド治療剤 (2012)
  • Inventor(s): 池田佳奈枝、鳥越俊彦、松本佳隆、藤田龍哉、四ッ柳高敏、佐藤昇志
  • Industrial Property Rights Holder: 北海道公立大学法人札幌医科大学
  • Filing Date: 2012-02-03
  • Overseas
• [Patent(Industrial Property Rights)] 改良された糖被覆リポソーム組成物 (2012)
  • Inventor(s): 梶原敏充、沼崎麻希、清水佳隆、鳥越俊彦、佐藤昇志、田村保明、小島直也
  • Industrial Property Rights Holder: 北海道公立大学法人札幌医科大学
  • Industrial Property Number: 2011-102962
  • Filing Date: 2012-02-03
• [Patent(Industrial Property Rights)] ケロイド治療剤 (2012)
  • Inventor(s): 池田佳奈枝、鳥越俊彦、松本佳隆、藤田龍哉、四ッ柳高敏、佐藤昇志
  • Industrial Property Rights Holder: 北海道公立大学法人札幌医科大学
  • Filing Date: 2012-02-03
• [Patent(Industrial Property Rights)] ケロイド治療剤 (2012)
  • Inventor(s): 池田佳奈枝、鳥越俊彦、松本佳隆、藤田龍哉、四ッ柳高敏、佐藤昇志
  • Industrial Property Rights Holder: 北海道公立大学法人札幌医科大学
  • Filing Date: 2012-02-03
  • Overseas
• [Patent(Industrial Property Rights)] SOX2由来のHLA-A24結合性癌抗原ペプチド (2010)
  • Inventor(s): 鳥越俊彦、廣橋良彦、中津川宗秀、佐藤昇志、高橋あかり
  • Industrial Property Rights Holder: 北海道公立大学法人札幌医科大学、JST
  • Filing Date: 2010-03-19
  • Overseas
• [Patent(Industrial Property Rights)] 抗原特異的T細胞誘導脳測定法 (2010)
  • Inventor(s): 鳥越俊彦、廣橋良彦、水内将人、佐藤昇志、鈴木哲、清水佳隆、佐藤雄一郎
  • Industrial Property Rights Holder: 鳥越俊彦、廣橋良彦、水内将人、佐藤昇志、鈴木哲、清水佳隆、佐藤雄一郎
  • Filing Date: 2010-08-30
  • Overseas
• [Patent(Industrial Property Rights)] インターフェロンα産生阻害剤 (2010)
  • Inventor(s): 田村保明、佐藤昇志、鳥越俊彦、齋藤慶太
  • Industrial Property Rights Holder: 田村保明、佐藤昇志、鳥越俊彦、齋藤慶太
  • Industrial Property Number: 2010-219422
  • Filing Date: 2010-09-29
• [Patent(Industrial Property Rights)] サバイビン由来のHLA-A24結合性癌抗原ペプチド (2010)
  • Inventor(s): 佐藤昇志、鳥越俊彦、廣橋良彦、井手之上里美、小林淳一
  • Industrial Property Rights Holder: 佐藤昇志、鳥越俊彦、廣橋良彦、井手之上里美、小林淳一
  • Industrial Property Number: 2004-191478
  • Filing Date: 2010-10-08
• [Patent(Industrial Property Rights)] がん幹細胞分子マーカー (2009)
  • Inventor(s): 鳥越俊彦、廣橋良彦、佐藤昇志、上口権二郎、守田玲菜、西澤哲、高橋あかり
  • Industrial Property Rights Holder: 北海道公立大学法人札幌医科大学、大日本住友製薬株式会社
  • Filing Date: 2009-10-27
  • Overseas
• [Patent(Industrial Property Rights)] がん幹細胞分子マーカー (2009)
  • Inventor(s): 鳥越俊彦, 廣橋良彦, 佐藤昇志, 上口権二郎, 守田玲菜, 西澤哲, 高橋あかり
  • Industrial Property Rights Holder: 鳥越俊彦, 廣橋良彦, 佐藤昇志, 上口権二郎, 守田玲菜, 西澤哲, 高橋あかり
  • Filing Date: 2009-10-27