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Basic studies for the immune responses against cancer stem cells of sold tumors

Research Project

Project/Area Number 21590401
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionSapporo Medical University

Principal Investigator

TORIGOE Toshihiko  札幌医科大学, 医学部, 准教授 (20301400)

Co-Investigator(Kenkyū-buntansha) HIROHASHI Yoshihiko  札幌医科大学, 医学部, 助教 (30516901)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords分子病理 / がん幹細胞 / がん抗原 / Cancer stem cell / がんワクチン / CEP55 / DNAJB8 / OR7C1 / Survivin / CTL / ペプチド / がん免疫療法 / 細胞障害性T細胞 / CTLエピトープ / 幹細胞 / がん / 抗原 / 免疫 / T細胞
Research Abstract

We investigated the immunopathological properties of cancer stem cells(CSCs), a small population of cancer cells with stem cell-like phenotype and tumor-initiating capacity. CSCs were collected from various cancer cell lines and analyzed for CSC-specific genes. Three genes were identified as candidates for CSC-specific antigens. We could induce CSC-specific cytotoxic T-cells(CTLs) from cancer patients. Adoptive transfer of the CTLs showed higher tumor suppressive capacity in vivo in a mouse model. Our studies demonstrated a potential of CSC-targeted immunotherapy.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (115 results)

All 2012 2011 2010 2009 2008 Other

All Journal Article (63 results) (of which Peer Reviewed: 60 results) Presentation (38 results) Book (4 results) Patent(Industrial Property Rights) (10 results) (of which Overseas: 5 results)

  • [Journal Article] Heat shock protein 40 family, DNAJB8 is expressed in renal cancer stem-like cell, controls the tumor-initiating ability and can be a potent target of immunotherapy.2012

    • Author(s)
      Nishizawa, S., Mori, T., Hirohashi, Y., Torigoe, T., Tamura, Y., Kamiguchi, K., Takahashi, A., Kanaseki, T., Nakazawa, E., Asanuma, H., Sokolovskaya, A., Morita, R., Yamada, R., Fujii, R., Kondo, T., Hasegawa, T., Hara, I. and Sato, N.
    • Journal Title

      Cancer Res

      Volume: (in press) Issue: 11 Pages: 2844-54

    • DOI

      10.1158/0008-5472.can-11-3062

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of a monoclonal anti-pan HLA class I antibody suitable for immunostaining of formalin-fixed tissue : Unusually high frequency of down-regulation in breast cancer tissues2012

    • Author(s)
      Torigoe, T., Asanuma, H., Nakazawa. E., Tamura, Y., Hirohashi, Y., Yamamoto, E., Kanaseki, T., Hasegawa, T., Sato, N.
    • Journal Title

      Pathol Int

      Volume: 62 Issue: 5 Pages: 303-8

    • DOI

      10.1111/j.1440-1827.2012.02789.x

    • NAID

      10031185205

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] ECRG4 is a negative regulator of caspase-8-mediated apoptosis in human T-leukemia cells2012

    • Author(s)
      Matsuzaki J,Torigoe T,Hirohashi Y, Kamiguchi K,Tamura Y, Tsukahara T,Kubo T, Takahashi A, Nakazawa E,Saka E, Yasuda K,Takahashi S,Sato N.
    • Journal Title

      Carcinogenesis

      Volume: 33 Issue: 5 Pages: 996-1003

    • DOI

      10.1093/carcin/bgs118

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel oligomannose liposome-DNA complex DNA vaccination efficiently evokes anti-HPV E6 and E7 CTL responses2012

    • Author(s)
      Mizuuchi M, Hirohashi Y, Torigoe T, Takafumi K, Yasuda K, Saito T, Sato N
    • Journal Title

      Exp Mol Pathol.

      Volume: 92 Issue: 1 Pages: 185-190

    • DOI

      10.1016/j.yexmp.2011.10.002

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Efficiency of G2/M-related tumor-associated antigen-targeting cancer immunotherapy depends on antigen expression in the cancer stem-like population2012

    • Author(s)
      Mori T, Nishizawa S, Hirohashi Y, Torigoe T, Tamura Y, Takahashi A, Kochin V, Fujii R, Toru K, Greene MI, Hara I, Sato N
    • Journal Title

      Exp Mol Pathol

      Volume: 92 Pages: 27-32

    • URL

      http://dx.doi.org/10.1016/j.yexmp.2011.09.016

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel oligomannose liposome-DNA complex DNA vaccination efficiently evokes anti-HPV E6 and E7 CTL responses2012

    • Author(s)
      Mizuuchi M
    • Journal Title

      Exp Mol Pathol

      Volume: 92(1) Pages: 185-190

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficiency of G2/M-related tumor-associated antigen-targeting cancer immunotherapy depends on antigen expression in the cancer stem-like population2012

    • Author(s)
      Takashi Mori, Satoshi Nishizawa, Yoshihiko Hirohashi, Toshihiko Torigoe, Yasuaki Tamura, Akari Takahashi, Vitaly Kochin, Reona Fujii, Kondo Toru, Mark I. Greene, Isao Hara, Noriyuki Sato
    • Journal Title

      Experimental and Molecular Pathology

      Volume: 92 Issue: 1 Pages: 27-32

    • DOI

      10.1016/j.yexmp.2011.09.016

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] SOX2 is expressed in stem-like cells of human lung adenocarcinoma and augments the tumor-initiating potential2011

    • Author(s)
      Nakatsugawa, M., Takahashi, A., Hirohashi, Y., Torigoe, T., Inoda, S., Asanuma, H., Tamura, Y., Hasegawa, T., Takahashi, H., and Sato, N.
    • Journal Title

      Lab Invest.

      Volume: 91 Issue: 12 Pages: 1796-1804

    • DOI

      10.1038/labinvest.2011.140

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tumor associated dendritic cells : molecular mechanisms to suppress anti-tumor immunity2011

    • Author(s)
      Hirohashi, Y. and Sato, N.
    • Journal Title

      Immunotherapy

      Volume: 3 Issue: 8 Pages: 945-947

    • DOI

      10.2217/imt.11.94

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tumor-Produced Secreted Form of Binding of Immunoglobulin Protein Elicits Antigen-Specific Tumor Immunity.2011

    • Author(s)
      Tamura Y, Hirohashi Y, Kutomi G, Nakanishi K, Kamiguchi K, Torigoe T, Sato N.
    • Journal Title

      J. Immunol

      Volume: 186 Issue: 7 Pages: 4325-4330

    • DOI

      10.4049/jimmunol.1004048

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Extracellular heat shock protein 90 plays a role in translocating chaperoned antigen from endosome to proteasome for generating antigenic peptide to be cross-presented by dendritic cells.2011

    • Author(s)
      Oura, J., Tamura, Y., Kamiguchi, K., Kutomi, G., Sahara, H., Torigoe, T., Himi, T., and Sato, N.
    • Journal Title

      Int. Immunol

      Volume: 23 Issue: 4 Pages: 223-237

    • DOI

      10.1093/intimm/dxq475

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Autologous CTL response against cancer stem-like cells/cancer-initiating cells of bone malignant fibrous histiocytoma2011

    • Author(s)
      Kano, M., Tsukahara, T., Emori, M., Murase, M., Torigoe, T., Kawaguchi, S., Wada, T., Yamashita, T., Sato, N.
    • Journal Title

      Cancer Sci

      Volume: 102 Issue: 8 Pages: 1443-1137

    • DOI

      10.1111/j.1349-7006.2011.01962.x

    • NAID

      10030241866

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunogenic enhancement and clinical effect by type-I interferon of anti-apoptotic protein, survivin-derived peptide vaccine, in advanced colorectal cancer patients2011

    • Author(s)
      Kameshima, H., Tsuruma, T., Torigoe, T., Takahashi, A., Hirohashi, Y., Tamura, Y., Tsukahara, T., Ichimiya, S., Kanaseki, T., Iwayama, Y., Sato, N., Hirata, K.
    • Journal Title

      Cancer Sci

      Volume: 102 Issue: 6 Pages: 1181-1187

    • DOI

      10.1111/j.1349-7006.2011.01918.x

    • NAID

      10029294487

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of speedy PCR-ssp method and serological typing of hla-a24 for Japanese cancer patients.2011

    • Author(s)
      Nakatsugawa M, Hirohashi Y, Torigoe T, Inoda S, Kiriyama K, Tamura Y, Sato E, Takahashi H, Sato N.
    • Journal Title

      J Immunoassay Immunochem

      Volume: 32 Issue: 2 Pages: 93-102

    • DOI

      10.1080/15321819.2010.543219

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cytotixic T lymphocytes efficiently recognize human colon cancer stem-like cells2011

    • Author(s)
      Inoda, S., Hirohashi, Y., Torigoe, T., Takahashi, A., Morita, R., Nakatsugawa, M., Nishizawa, S., Tamura, Y., Tsuruma, T., Terui, T., Ishitani, K., Hirata, K. and Sato, N.
    • Journal Title

      Am. J. Pathol.

      Volume: 178 Issue: 4 Pages: 1805-1813

    • DOI

      10.1016/j.ajpath.2011.01.004

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phase I clinical trial of survivin-derived peptide vaccine therapy for patients with advanced or recurrent oral cancer2011

    • Author(s)
      Miyazaki A, Kobayashi J, Torigoe T, Hirohashi Y, Yamamoto T, Yamaguchi A, Asanuma H, Takahashi A, Michifuri Y, Nakamori K, Nagai I, Sato N, Hiratsuka H.
    • Journal Title

      Cancer Sci

      Volume: 102 Issue: 2 Pages: 324-329

    • DOI

      10.1111/j.1349-7006.2010.01789.x

    • NAID

      10029289826

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The feasibility of Cep55/c10orf3 derived peptide vaccine therapy for colorectal carcinoma2011

    • Author(s)
      Inoda S, Morita R, Hirohashi Y, Torigoe T, Asanuma H, Nakazawa E, Nakatsugawa M, Tamura Y, Kamiguchi K, Tsuruma T, Terui T, Ishitani K, Hashino S, Wang Q, Greene MI, Hasegawa T, Hirata K, Asaka M, Sato N.
    • Journal Title

      Exp. Mol. Pathol.

      Volume: 90 Issue: 1 Pages: 55-60

    • DOI

      10.1016/j.yexmp.2010.10.001

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Autoantibody against hypoxia-inducible factor prolyl hydroxylase-3 is a potential serological marker for renal cell carcinoma2011

    • Author(s)
      Tanaka, T., Kitamura, H., Torigoe, T., Hirohashi, Y., Masumori, N., Sato, N. and Tsukamoto, T.
    • Journal Title

      J. Cancer Res. Clin. Oncol

      Volume: 137 Issue: 5 Pages: 789-794

    • DOI

      10.1007/s00432-010-0940-6

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of an HLA-A*0201-restricted cytotoxic T lymphocyte epitope from the lung carcinoma antigen, Lengsin2011

    • Author(s)
      Nakatsugawa M
    • Journal Title

      Int J Oncol

      Volume: 39(4) Pages: 1041-1049

    • DOI

      10.3892/ijo.2011.1089

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cytotoxic T lymphocytes efficiently recognize human colon cancer stem-like cells2011

    • Author(s)
      Inoda S
    • Journal Title

      Am J Pathol

      Volume: 178(4) Pages: 1805-1813

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tumor-produced secreted form of binding of immunoglobulin protein elicits antigen-specific tumor immunity2011

    • Author(s)
      Tamura Y
    • Journal Title

      J Immunol

      Volume: 186(7) Pages: 4325-4330

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autoantibody against hypoxia-inducible factor prolyl hydroxylase-3 is a potential serological marker for renal cell carcinoma2011

    • Author(s)
      Tanaka T
    • Journal Title

      J Cancer Res Clin Oncol

      Volume: 137(5) Pages: 789-794

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A phase I clinical trial of survivin-derived peptide vaccine therapy in HLA-A24-positive patients with oral cancer.2011

    • Author(s)
      Miyazaki A, Torigoe T, et al.
    • Journal Title

      Cancer Sci.

      Volume: 102 Pages: 324-9

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spatiotemporal regulation of heat shock protein 90-chaperoned self-DNA and CpG-oligodeoxynucleotide for type I IFN induction via targeting to static early endosome2010

    • Author(s)
      Okuya, K., Tamura, Y., Saito, K., Kutomi, G., Torigoe, T., Hirata, K., Sato, N.
    • Journal Title

      J. Immunol

      Volume: 184 Issue: 12 Pages: 7092-7099

    • DOI

      10.4049/jimmunol.1000490

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immune response against tumor antigens expressed on human cancer stem-like cells/tumor-initiating cells2010

    • Author(s)
      Hirohashi, Y., Torigoe, T., Inoda, S., Takahashi, A., Morita, R., Nishizawa, S., Tamura, Y., Suzuki, H., Yoyota, M. Sato, N.
    • Journal Title

      Immunotherapy

      Volume: 2 Pages: 201-211

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Extracellular heat shock protein 90 (Hsp90) directs self-DNA to static early endosome-resident TLR-9, leading to type I interferon production.2010

    • Author(s)
      Okuya, K., Torigoe, T., et al.
    • Journal Title

      J.Immunol.

      Volume: 184 Pages: 7092-7099

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of shared antigen reactive cytotoxic T lymphocyte using co-stimulatory molecule introduced autologous cancer cells. Exp Mol Pathol.2010

    • Author(s)
      Hirohashi, Y., Torigoe, T., et al.
    • Journal Title

      Exp Mol Pathol.

      Volume: 88 Pages: 128-132

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autoantibody against hypoxia-inducible factor prolyl hydroxylase-3 is a potential marker for renal cell carcinoma.2010

    • Author(s)
      Tanaka T, Torigoe T, et al.
    • Journal Title

      J Cancer Res Clin Oncol.

      Volume: (印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The feasibility of Cep55/c10orf3 derived peptide vaccine therapy for colorectal carcinoma.2010

    • Author(s)
      Inoda S, Torigoe T, et al.
    • Journal Title

      Exp Mol Pathol.

      Volume: 90 Pages: 55-60

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immune response against tumor antigens expressed on human cancer-stem cells/tumor-initiating cells.2010

    • Author(s)
      Hirohashi Y., Torigoe T., et al.
    • Journal Title

      Immunotherapy

      Volume: 2 Pages: 201-211

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immune response against tumor antigens expressed on human cancer-stem cells/tumor-initiating cells2010

    • Author(s)
      廣橋良彦, et al
    • Journal Title

      Immunotherapy 2

      Pages: 201-211

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of shared antigen reactive cytotoxic T lymphocyte using co-stimulatory molecule introduced autologous cancer cells2010

    • Author(s)
      廣橋良彦, et al
    • Journal Title

      Exp Mol Pathol. 88

      Pages: 128-132

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Side population cells have the characteristics of cancer stem-like cells/cancer-initiating cells in bone sarcomas2009

    • Author(s)
      Murase, M., Kano, M., Tsukahara, T., Takahashi, A., Torigoe, T., Kawaguchi, S., Kimura, S., Wada, T., Uchihashi, Y., Kondo, T., Yamashita, T. and Sato N.
    • Journal Title

      Brit. J. Cancer

      Volume: 101 Issue: 8 Pages: 1425-1432

    • DOI

      10.1038/sj.bjc.6605330

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Targeting to static endosome is required for efficient cross-presentation of endoplasmic reticulum-resident oxygen regulated protein 150(ORP150)-peptide complexes2009

    • Author(s)
      Kutomi, G., Tamura, Y., Okuya, K., Hirohashi, Y., Kamiguchi, K., Saito, K., Torigoe, T., Ogawa, S., Hirata, K. and Sato, N.
    • Journal Title

      J. Immunol

      Volume: 183 Issue: 9 Pages: 5861-5869

    • DOI

      10.4049/jimmunol.0803768

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Heat shock proteins and immunity : application of hyperthermia for immunomodulation2009

    • Author(s)
      Torigoe, T., Tamura, Y., Sato, N.
    • Journal Title

      Int. J. Hyperthermia

      Volume: 25 Issue: 8 Pages: 610-616

    • DOI

      10.3109/02656730903315831

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant expression and potency as a cancer immunotherapy target of alpha-methylacyl-coenzyme A racemase in prostate cancer2009

    • Author(s)
      Honma, I., Torigoe, T., Hirohashi, Y., Kitamura, H., Sato, E., Masumori, N., Tamura, Y., Tsukamoto, T., Sato, N.
    • Journal Title

      J. Transl. Med

      Volume: 7 Issue: 1 Pages: 103-110

    • DOI

      10.1186/1479-5876-7-103

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of shared antigen reactive cytotixic T lymphocytes using co-stimulatory molecule introduced autologous cancer cells2009

    • Author(s)
      Hirohashi, Y., Torigoe, T., Hirai, I., Tamura, Y., Nakatsugawa, M., Inoue, Y., Kanaseki, T., Kamiguchi, K., Ikeda, H., Sasaki, A., Yamanaka, N. and Sato, N.
    • Journal Title

      Exp. Mol. Pathol.

    • URL

      http://dx.doi.org/10.1016/j.yexmp.2009.09.021

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Human leukocyte antigen class I down-regulation in muscle-invasive bladder cancer : Its association with clinical characteristics and survival after cystectomy2009

    • Author(s)
      Homma, I., Kitamura, H., Torigoe, T., Tanaka, T., Sato, E., Hirohashi, Y., Masumori, N., Sato, N. and Tsukamoto, T.
    • Journal Title

      Cancer Sci

      Volume: 100 Issue: 12 Pages: 2331-2334

    • DOI

      10.1111/j.1349-7006.2009.01329.x

    • NAID

      10027198144

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel spliced form of a lens protein as a novel lung cancer antigen2009

    • Author(s)
      Nakatsugawa, M. Hirohashi, Y., Torigoe, T., Asanuma, H., Takahashi, A., Inosa, S., Kiriyama, K., Nakazawa, E., Harada, K., Takasi, H., Tamura, Y., Kamiguchi, K., Shijubo, N., Honda, R., Nomura, N., Hasegawa, T., Takahashi, H. and Sato, N.
    • Journal Title

      Cancer Sci

      Volume: 100 Issue: 8 Pages: 1485-1493

    • DOI

      10.1111/j.1349-7006.2009.01187.x

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] HLA-A 0201-restricted CTL epitope of a novel osteosarcoma antigen, papillomavirus binding factor2009

    • Author(s)
      Tsukahara, T., Kawaguchi, S., Torigoe, T., Takahashi, A., Murase, M., Kano, M., Wada, T., Kaya, M., Nagoya, S., Yamashita, T. and Sato, N.
    • Journal Title

      J. Transl. Med

      Volume: 7 Issue: 1 Pages: 44-51

    • DOI

      10.1186/1479-5876-7-44

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular pathologic approaches to human tumor immunology2009

    • Author(s)
      Sato, N., Hirohashi, Y., Tsukahara, T., Kikuchi, T., Sahara, H., Kamiguchi, K., Ichimiya, S., Tamura, H. and Torigoe, T.
    • Journal Title

      Pathol. Int

      Volume: 59 Issue: 4 Pages: 205-217

    • DOI

      10.1111/j.1440-1827.2009.02353.x

    • NAID

      10027379604

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Polyamine compound deoxyspergualin inhibits heat shock protein-induced activation of immature dendritic cells2009

    • Author(s)
      Sugawara, A., Torigoe, T., Tamura, Y., Kamiguchi, K., Nemoto, K., Oguro, H., Sato, N.
    • Journal Title

      Cell Stress Chaperone

      Volume: 14 Issue: 2 Pages: 133-139

    • DOI

      10.1007/s12192-008-0064-y

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The functioning antigens ; beyond just as the immunologic targets2009

    • Author(s)
      Hirohashi, Y., Torigoe, T., Inoda, S., Kobayashi, J., Nakatsugawa, M., Mori, T., Hara, I. and Sato, N.
    • Journal Title

      Cancer Sci

      Volume: 100 Issue: 5 Pages: 798-806

    • DOI

      10.1111/j.1349-7006.2009.01137.x

    • NAID

      10025145179

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cep55/c10orf3, a tumor antigen derived from a centrosome residing protein in breast carcinoma2009

    • Author(s)
      Inoda, S., Hirohashi, Y., Torigoe, T., Nakatsugawa, M., Kiriyama, K., Harada, K., Takasu, H., Tamura, Y., Kamiguchi, K., Asanuma, H., Tsuruma, T., Terui, T., Ishitani, K., Ohmura, T., Hasegawa, T., Hirata, K. and Sato, N.
    • Journal Title

      J. Immunother.

      Volume: 32 Pages: 474-485

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phase I clinical study of anti-apoptosis protein survivin-derived peptide vaccination for patients with advanced or recurrent urothelial cancer2009

    • Author(s)
      Honma, I., Kitamura, H., Torigoe, A. Takahashi, T., Tanaka, T., Sato, E., Hirohashi, Y., Masumori, N., Tsukamoto, T., Sato, N.
    • Journal Title

      Cancer Immunol. Immunother

      Volume: 58 Issue: 11 Pages: 1801-1807

    • DOI

      10.1007/s00262-009-0691-x

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clonal diversity of cytotoxic T lymphocytes that recognize autologous oral squamous cell carcinoma2009

    • Author(s)
      Kobayashi, J., Torigoe, T., Hirohashi, Y., Tamura, Y., Kamiguchi, K., Miyazaki, A., Yamaguchi, A., Yamamoto, T., Hariu, H., Hiratsuka, H. and Sato, N.
    • Journal Title

      Hum Immunol.

      Volume: 70 Pages: 89-95

    • URL

      http://dx.doi.org/10.1016/j.humimm.2008.11.004

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparative study on the immunogenicity between an HLA-A24-restricted cytotoxic T-cell epitope derived from surviving and that from its splice variant surviving-2B in oral cancer patients2009

    • Author(s)
      Kobayashi, J., Torigoe, T., Hirohashi, Y., Idenoue, S., Miyazaki, A., Yamaguchi, A., Hiratsuka, H. and Sato, N.
    • Journal Title

      J. Transl. Med

      Volume: 7 Issue: 1 Pages: 1-11

    • DOI

      10.1186/1479-5876-7-1

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunosuppressive effect on T cell activation by interleukin-16 and interleukin 10 cDNA-double-transfected human squamous cell line2009

    • Author(s)
      Matsumoto, Y., Fujita, T., Hirai, I., Sahara, H., Torigoe, T., Ezoe, K., Saito, Y., Cruikshank, W. W., Yotsuyanagi, T. and Sato, N.
    • Journal Title

      Burns

      Volume: 35 Pages: 383-389

    • URL

      http://dx.doi.org/10.1016/j.burns.2008.06.017

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Side population cells have the characteristics of cancer stem-like cells/cancer-initiating cells in bone sarcomas2009

    • Author(s)
      Murase, M., et al
    • Journal Title

      Br J Cancer. 101

      Pages: 1425-1432

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant expression and potency as a cancer immunotherapy target of alpha-methylacyl-coenzyme A racemase in prostate cancer2009

    • Author(s)
      Honma, I., et al
    • Journal Title

      J Transl.Med. 7

      Pages: 103-113

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparative study on the immunogenicity between an HLA-A24-restricted cytotoxic T-cell epitope derived from surviving and that from its splice variant surviving-2B in oral cancer patients2009

    • Author(s)
      Kobayashi, J., et al
    • Journal Title

      J.Transl.Med. 7

      Pages: 1-11

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] HLA-A^*0201-restricted clonal CTL epitope of a novel osteosarcoma antigen, papil lomavirus binding factor2009

    • Author(s)
      Tsukahara, T., et al
    • Journal Title

      J.Transl.Med. 12;7

      Pages: 44-44

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phase Iclinical study of anti-apoptosis protein survivin-derived peptidevaccination for patients with advanced or recurrent urothelial cancer2009

    • Author(s)
      Honma, I., et al
    • Journal Title

      Cancer Immunol.Immunother. 58

      Pages: 1801-1807

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel spliced form of a lens protein as a novel lung cancer antigen, Lengsin splicing variant 42009

    • Author(s)
      Nakatsugawa, M., et al
    • Journal Title

      Cancer Sci. 100

      Pages: 1485-1493

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cep55/c10orf3, a tumor antigen derived from a centrosome residing protein in breast carcinoma2009

    • Author(s)
      Inoda, S., et al
    • Journal Title

      J Immunother. 32

      Pages: 474-485

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human leukocyte antigen class I down-regulation in muscle-invasive bladder cancer : Its association with clinical characteristics and survival after cystectomy2009

    • Author(s)
      Homma, I., et al
    • Journal Title

      Cancer Sci. 100

      Pages: 2331-2334

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The functioning antigens ; beyond just as the immunologic targets2009

    • Author(s)
      廣橋良彦, et al
    • Journal Title

      Cancer Sci. 100

      Pages: 798-806

    • NAID

      10025145179

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular pathologic approaches to human tumor immunology2009

    • Author(s)
      Sato, N., et al
    • Journal Title

      Pathol.Int. 59

      Pages: 205-217

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] がん幹細胞抗原の検索とがんワクチンへの応用2009

    • Author(s)
      廣橋良彦, 他
    • Journal Title

      最新医学 64

      Pages: 27-36

    • Related Report
      2009 Annual Research Report
  • [Journal Article] がんの免疫逃避メカニズムとその制御2009

    • Author(s)
      守田玲菜, 他
    • Journal Title

      臨床血液 50

      Pages: 375-380

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Scythe/BAT3 regulates apoptotic cell death induced by papillomavirus binding factor in human osteosarcoma2008

    • Author(s)
      Tsukahara, T., Kimura, S., Ichimiya, S., Torigoe, T., Kawaguchi, S., Wada, T., Yamashita, T., Sato, N.
    • Journal Title

      Cancer Sci

      Volume: 100 Issue: 1 Pages: 47-53

    • DOI

      10.1111/j.1349-7006.2008.00991.x

    • NAID

      10025141244

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] DNA methyltransferase 1 is essential for maintenance of human colon cancer stem-like cells

    • Author(s)
      Morita, R., Hirohashi, Y., Torigoe, T., Takahashi, A., Saka, E., Asanuma, H., Suzuki, H., Tamura, H., Nakazawa, E., Ito-Inoda, S., Hashino, S., Hasegawa, T., Tokino, T., Toyota, M., Asaka, M. and Sato, N.
    • Journal Title

      Am J. Pathol.

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Heat shock protein 90 governs self-nucleic acid recognition by Toll-like receptors

    • Author(s)
      Saito, K., Tamura, Y., Kukita, K., Kutomi, G., Okuya, K., Asanuma, H., Torigoe, T., Hirata, K., Sato, N.
    • Journal Title

      Nature

    • Related Report
      2011 Final Research Report
  • [Presentation] がん幹細胞の免疫病理学的特性の解析:がん幹細胞標的治療へ向けて2011

    • Author(s)
      鳥越俊彦、廣橋良彦、佐藤昇志
    • Organizer
      バイオセラピィ学会シンポジウム
    • Place of Presentation
      和歌山
    • Year and Date
      2011-12-01
    • Related Report
      2011 Final Research Report
  • [Presentation] がん幹細胞の免疫病理学的特性の解析:がん幹細胞標的治療へ向けて2011

    • Author(s)
      鳥越俊彦
    • Organizer
      バイオセラピー学会シンポジウム
    • Place of Presentation
      和歌山(招待講演)
    • Year and Date
      2011-12-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] がん幹細胞を標的とする免疫療法2011

    • Author(s)
      廣橋良彦、鳥越俊彦、井野田智子、守田玲菜、高橋あかり、中津川宗秀、道振義貴、佐藤昇志
    • Organizer
      第70回日本癌学会学術総会、シンポジウム
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-03
    • Related Report
      2011 Final Research Report
  • [Presentation] がん幹細胞の免疫学的特性とワクチン開発2011

    • Author(s)
      鳥越俊彦、廣橋良彦、田村保明、佐藤昇志
    • Organizer
      がん免疫学会シンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2011-06-30
    • Related Report
      2011 Final Research Report
  • [Presentation] がん幹細胞の免疫学的特性とワクチン開発2011

    • Author(s)
      鳥越俊彦
    • Organizer
      がん免疫学会シンポジウム
    • Place of Presentation
      大阪(招待講演)
    • Year and Date
      2011-06-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] 難治がんに対するペプチドワクチン療法:現状と課題2011

    • Author(s)
      鳥越俊彦
    • Organizer
      北海道癌談話会シンポジウム
    • Place of Presentation
      札幌(招待講演)
    • Year and Date
      2011-06-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] がん組織の微小環境と免疫2011

    • Author(s)
      鳥越俊彦
    • Organizer
      第100回日本病理学会学術総会、シンポジウム
    • Place of Presentation
      横浜
    • Year and Date
      2011-04-28
    • Related Report
      2011 Final Research Report
  • [Presentation] がん幹細胞の免疫学的特性とワクチン開発2011

    • Author(s)
      鳥越俊彦、廣橋良彦、佐藤昇志
    • Organizer
      第13回癌治療増感研究シンポジウム
    • Place of Presentation
      奈良
    • Year and Date
      2011-02-11
    • Related Report
      2011 Final Research Report
  • [Presentation] 次世代がんワクチン:がん幹細胞標的ペプチドワクチンの実用化研究2011

    • Author(s)
      鳥越俊彦、廣橋良彦、守田玲菜、田村保明、平田公一、佐藤昇志
    • Organizer
      日本癌治療学会シンポジウム
    • Place of Presentation
      名古屋
    • Related Report
      2011 Final Research Report
  • [Presentation] Exploration of pathological properties of cancer stem cells(CSCs)2011

    • Author(s)
      Toshihiko Torigoe
    • Organizer
      CSC-specific mitochondrial protein and heat shock protein 5th Biennial Meeting of Society for Free Radical Research-Asia
    • Place of Presentation
      Kagoshima, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] Stress Response Genes Expressed in Cancer Stem Cells-potent molecular targets for cancer therapy-2011

    • Author(s)
      Toshihiko Torigoe, Hirohashi Yoshihiko, Yasuaki Tamura, Noriyuki Sato
    • Organizer
      The 5^<th> International Congress on Stress Responses in Biology and Medicine
    • Place of Presentation
      Quebec City, Canada.
    • Related Report
      2011 Final Research Report
  • [Presentation] 次世代がんワクチン:がん幹細胞標的ペプチドワクチンの実用化研究2011

    • Author(s)
      鳥越俊彦
    • Organizer
      日本癌治療学会シンポジウム
    • Place of Presentation
      名古屋(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Exploration of pathological properties of cancer stem cells (CSCs) : CSC-specific mitochondrial protein and heat shock protein2011

    • Author(s)
      Toshihiko Torigoe
    • Organizer
      The 5th Biennial Meeting of Society for Free Radical Research-Asia
    • Place of Presentation
      Kagoshima, Japan(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Stress Response Genes Expressed in Cancer Stem Cells-potent molecular targets for cancer therapy-2011

    • Author(s)
      Toshihiko Torigoe
    • Organizer
      The 5^<th> International Congress on Stress Resp onses in Biology and Medicine
    • Place of Presentation
      Quebec City, Canada(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Immune responses against cancer stem cells2010

    • Author(s)
      Toshihiko Torigoe, Yoshihiko Hirohashi, Noriyuki Sato
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-22
    • Related Report
      2011 Final Research Report
  • [Presentation] Immune responses against cancer stem cells.2010

    • Author(s)
      Toshihiko Torigoe
    • Organizer
      第69回日本癌学会学術総会、シンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] Cancer initiating cellを標的とした免疫療法の基礎的研究2010

    • Author(s)
      鳥越俊彦、廣橋良彦、佐藤昇志
    • Organizer
      日本がん免疫学会、シンポジウム
    • Place of Presentation
      熊本
    • Year and Date
      2010-07-22
    • Related Report
      2011 Final Research Report
  • [Presentation] 乳がんに対する免疫療法研究最前線-がん幹細胞抗原と免疫逃避の制御-2010

    • Author(s)
      鳥越俊彦
    • Organizer
      乳がん学会総会、シンポジウム
    • Place of Presentation
      札幌
    • Year and Date
      2010-06-25
    • Related Report
      2011 Final Research Report
  • [Presentation] Development of Cancer Stem Cell Vaccine2010

    • Author(s)
      Toshihiko Torigoe
    • Organizer
      The 25^<th> International Society for Biological Therapy of Cancer
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] A novel DNAJ family protein is a cancer initiating cell antigen.-A potent molecular target for cancer immunotherapy-2010

    • Author(s)
      Toshihiko Torigoe, Yoshihiko Hirohashi, Satoshi Nishizawa, Akari Takahashi, Hiroko Asanuma, Munehide Nakatsugawa, Kenjiro Kamiguchi, Alisa A. Sokolovskaya, Noriyuki Sato.
    • Organizer
      The 8^<th> International Workshop on the Molecular Biology of Stress Responses
    • Place of Presentation
      Seorak Mt., Korea
    • Related Report
      2011 Final Research Report
  • [Presentation] Development of Cancer Stem Cell Vaccine2010

    • Author(s)
      Toshihiko Torigoe
    • Organizer
      8^<th> AACR/JCA Joint Conference : Cancer Genomics, Epigenomics, and the Development of Novel Therapeutics
    • Place of Presentation
      Waikoloa, Hawaii, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] A novel DNAJ family protein is a cancer initiating cell antigen. -A potent molecular target for cancer immunotherapy-2010

    • Author(s)
      Toshihika Torigoe
    • Organizer
      The 8^<th> International Workshop on the Molecular Biology of Stress Responses
    • Place of Presentation
      Seorak Mt., Korea
    • Related Report
      2010 Annual Research Report
  • [Presentation] MHC class I expression is down-regulated through epithelial-mesenchymal transition of breast cancer.2010

    • Author(s)
      T.Torigoe
    • Organizer
      14^<th> International Congress on Immunology
    • Place of Presentation
      Kobe, Japan
    • Related Report
      2010 Annual Research Report
  • [Presentation] Development of Cancer Stem Cell Vaccine.2010

    • Author(s)
      Toshihiko Torigoe
    • Organizer
      The 25^<th> International Society for Biological Therapy of Cancer.
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Exploration of molecular markers for cancer stem cells and the possible application to tageting therapy. 8th AACR/JCA Joint Conference2010

    • Author(s)
      Torigoe, T.
    • Organizer
      Cancer Genomics, Epigenomics, and the Development of Novel Therapeutics
    • Place of Presentation
      Hawaii
    • Related Report
      2009 Annual Research Report
  • [Presentation] ペプチドがんワクチン開発のトランスレーショナルリサーチ~ますます重要性を帯びる基礎医学研究基盤~2009

    • Author(s)
      鳥越俊彦
    • Organizer
      第6回日本免疫治療学研究会
    • Place of Presentation
      東京
    • Year and Date
      2009-02-21
    • Related Report
      2011 Final Research Report
  • [Presentation] ヒト医療におけるがんワクチン療法の現状と課題2009

    • Author(s)
      鳥越俊彦
    • Organizer
      日本獣医臨床病理学会
    • Place of Presentation
      東京
    • Year and Date
      2009-02-15
    • Related Report
      2011 Final Research Report
  • [Presentation] がん幹細胞抗原の解析とがんワクチン臨床試験2009

    • Author(s)
      鳥越俊彦
    • Organizer
      From Bench to Bedside and Lesson from the Bedside埼玉血液懇談会
    • Place of Presentation
      埼玉
    • Year and Date
      2009-01-14
    • Related Report
      2011 Final Research Report
  • [Presentation] 自然免疫内因性リガントとしてのストレス蛋白質による自己免疫疾患病態制御2009

    • Author(s)
      田村保明、鳥越俊彦、佐藤昇志
    • Organizer
      第37回日本臨床免疫学会総会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] Can immune system recognize and attack cancer stem cells?2009

    • Author(s)
      Torigoe, T.
    • Organizer
      Cancer Stem Cell Symposium
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2011 Final Research Report
  • [Presentation] Apoptosis regulator protein PBF is an immunological target for patients with osteosarcoma2009

    • Author(s)
      Tsukahara, T., Kawaguchi, S., Kano, M., Wada, T., Yamashita, T., Torigoe, T., Takahashi, A. and Sato, N.
    • Organizer
      24^<th> Annual Meeting of International Society for Biological Therapy of Cancer
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Identification of cancer stem cell antigens revealed unique characteristics of triple negative breast cancer2009

    • Author(s)
      Torigoe, T., Hirohashi, Y., Takahashi, A., Asanuma, H., Nakatsugawa, M., Inoda, S., Sato, N.
    • Organizer
      14th World Congress on Advances in Oncology and 12th International Symposium on Molecular Medicine
    • Place of Presentation
      Loutraki, Greece
    • Related Report
      2011 Final Research Report
  • [Presentation] Development of HSP90-based cancer vaccine and its mechanism2009

    • Author(s)
      Tamura, Y., Okuya, K., Saito, K., Torigoe, T., Sato, N.
    • Organizer
      The 4th International Congress on Stress Responses in Biology and Medicine/The 4th Annual Meeting of the Biomedical Society for Stress Response
    • Place of Presentation
      Sapporo
    • Related Report
      2011 Final Research Report
  • [Presentation] Cancer Stem Cell Genes-potent molecular targets for cancer stem cell therapy-2009

    • Author(s)
      Torigoe, T.
    • Organizer
      The 4th International Congress on Stress Responses in Biology and Medicine/The 4th Annual Meeting of the Biomedical Society for Stress Response
    • Place of Presentation
      Sapporo
    • Related Report
      2011 Final Research Report
  • [Presentation] Functional analysis of novel mitochondrial proteins2009

    • Author(s)
      Torigoe, T.
    • Organizer
      ECRG4 and SMCP
    • Place of Presentation
      Free Radical School in Jap an Minami Uonuma, Niigata
    • Related Report
      2011 Final Research Report
  • [Presentation] ヒト癌幹細胞に対する免疫応答2009

    • Author(s)
      廣橋良彦、鳥越俊彦、佐藤昇志
    • Organizer
      免疫アジュバント研究会
    • Place of Presentation
      洞爺
    • Related Report
      2011 Final Research Report
  • [Presentation] Isolation of Cancer Stem Cells and Identification of Cancer Stem Cell Markers2009

    • Author(s)
      Torigoe, T.
    • Organizer
      Abbott Diagnostics Division Centers of Excellence Conference Paris
    • Place of Presentation
      France
    • Related Report
      2011 Final Research Report
  • [Presentation] Can immune system recognize and attack cancer stem cells?2009

    • Author(s)
      Torigoe, T.
    • Organizer
      Cancer Stem Cell Symposium
    • Place of Presentation
      Korea
    • Related Report
      2009 Annual Research Report
  • [Book] がん免疫療法の標的抗原、がん免疫療法-実用化へのチャレンジ-2010

    • Author(s)
      守田玲菜、廣橋良彦、鳥越俊彦、佐藤昇志
    • Publisher
      シーエムシー出版
    • Related Report
      2011 Final Research Report
  • [Book] Cancer, Immunology and Photonics S cience. Optical Devices and Systems, Biomedical and Green Technologies.2010

    • Author(s)
      Noriyuki Sato, Yoshihiko Hirohashi, Tomohide Tsukahara, Shingo Ichimiya, Yasuaki Tamura and Toshihiko Torigoe
    • Related Report
      2011 Final Research Report
  • [Book] がん免疫療法の標的抗原、がん免疫療法-実用化へのチャレンジ-2010

    • Author(s)
      守田玲菜、鳥越俊彦, et al.
    • Publisher
      シーエムシー出版
    • Related Report
      2010 Annual Research Report
  • [Book] バイオ医薬の開発技術とシーズ.第30章がんペプチド免疫治療2009

    • Author(s)
      佐藤昇志、廣橋良彦、塚原智英、田村保明、一宮慎吾、鳥越俊彦
    • Publisher
      シーエムシー出版
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] ケロイド治療剤2012

    • Inventor(s)
      池田佳奈枝、鳥越俊彦、松本佳隆、藤田龍哉、四ッ柳高敏、佐藤昇志
    • Industrial Property Rights Holder
      北海道公立大学法人札幌医科大学
    • Filing Date
      2012-02-03
    • Related Report
      2011 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 改良された糖被覆リポソーム組成物2012

    • Inventor(s)
      梶原敏充、沼崎麻希、清水佳隆、鳥越俊彦、佐藤昇志、田村保明、小島直也
    • Industrial Property Rights Holder
      北海道公立大学法人札幌医科大学
    • Industrial Property Number
      2011-102962
    • Filing Date
      2012-02-03
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Patent(Industrial Property Rights)] ケロイド治療剤2012

    • Inventor(s)
      池田佳奈枝、鳥越俊彦、松本佳隆、藤田龍哉、四ッ柳高敏、佐藤昇志
    • Industrial Property Rights Holder
      北海道公立大学法人札幌医科大学
    • Filing Date
      2012-02-03
    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] ケロイド治療剤2012

    • Inventor(s)
      池田佳奈枝、鳥越俊彦、松本佳隆、藤田龍哉、四ッ柳高敏、佐藤昇志
    • Industrial Property Rights Holder
      北海道公立大学法人札幌医科大学
    • Filing Date
      2012-02-03
    • Related Report
      2011 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] SOX2由来のHLA-A24結合性癌抗原ペプチド2010

    • Inventor(s)
      鳥越俊彦、廣橋良彦、中津川宗秀、佐藤昇志、高橋あかり
    • Industrial Property Rights Holder
      北海道公立大学法人札幌医科大学、JST
    • Filing Date
      2010-03-19
    • Related Report
      2011 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 抗原特異的T細胞誘導脳測定法2010

    • Inventor(s)
      鳥越俊彦、廣橋良彦、水内将人、佐藤昇志、鈴木哲、清水佳隆、佐藤雄一郎
    • Industrial Property Rights Holder
      鳥越俊彦、廣橋良彦、水内将人、佐藤昇志、鈴木哲、清水佳隆、佐藤雄一郎
    • Filing Date
      2010-08-30
    • Related Report
      2010 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] インターフェロンα産生阻害剤2010

    • Inventor(s)
      田村保明、佐藤昇志、鳥越俊彦、齋藤慶太
    • Industrial Property Rights Holder
      田村保明、佐藤昇志、鳥越俊彦、齋藤慶太
    • Industrial Property Number
      2010-219422
    • Filing Date
      2010-09-29
    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] サバイビン由来のHLA-A24結合性癌抗原ペプチド2010

    • Inventor(s)
      佐藤昇志、鳥越俊彦、廣橋良彦、井手之上里美、小林淳一
    • Industrial Property Rights Holder
      佐藤昇志、鳥越俊彦、廣橋良彦、井手之上里美、小林淳一
    • Industrial Property Number
      2004-191478
    • Filing Date
      2010-10-08
    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] がん幹細胞分子マーカー2009

    • Inventor(s)
      鳥越俊彦、廣橋良彦、佐藤昇志、上口権二郎、守田玲菜、西澤哲、高橋あかり
    • Industrial Property Rights Holder
      北海道公立大学法人札幌医科大学、大日本住友製薬株式会社
    • Filing Date
      2009-10-27
    • Related Report
      2011 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] がん幹細胞分子マーカー2009

    • Inventor(s)
      鳥越俊彦, 廣橋良彦, 佐藤昇志, 上口権二郎, 守田玲菜, 西澤哲, 高橋あかり
    • Industrial Property Rights Holder
      鳥越俊彦, 廣橋良彦, 佐藤昇志, 上口権二郎, 守田玲菜, 西澤哲, 高橋あかり
    • Filing Date
      2009-10-27
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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