| Project/Area Number |
21590402
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Iwate Medical University |
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Principal Investigator |
HABANO Wataru 岩手医科大学, 薬学部, 准教授 (50332979)
|
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| Co-Investigator(Kenkyū-buntansha) |
小沢 正吾 岩手医科大学, 薬学部, 教授 (20185581)
蒲生 俊恵 岩手医科大学, 薬学部, 助手 (00464701)
菅井 有 岩手医科大学, 医学部, 教授 (20187628)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 癌 / ゲノム不安定化 / 薬剤感受性 / エピジェネティクス |
|---|
| Research Abstract |
Inter-individual differences in drug efficacy and toxicity are often observed in cancer chemotherapy. Drug resistance is an especially difficult problem. Therefore, understanding the mechanism of such variability in drug response is the key to personalized drug therapy. This study found that DNA methylation plays a role in the regulation of drug-metabolizing enzymes and can be associated with the variability in drug response. DNA methylation is expected to provide useful information for cancer chemotherapy.
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