Cancerization and invasion of pancreatic neoplasm : Toward the approach for targeted therapy

• Project/Area Number: 21590403
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Human pathology
• Research Institution: Saitama Medical University
• Principal Investigator: SHIMIZU Michio 埼玉医科大学, 医学部, 教授 (60226256)
• Co-Investigator(Kenkyū-buntansha): 清水 禎彦 埼玉医科大学, 医学部, 准教授 (20206220)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 診断病理学 / 膵腫瘍 / 膵癌 / ランゲルハンス島 / 免疫組織化学 / 浸潤様式 / 扁平上皮 / p63 / CD44 / 発育様式 / 腺房 / 膵管 / 免疫三重染色 / low-grade PanIN / gastric type IPMN / ITPN / intestinal type IPMN / pancreatic adenocarcinoma / adenocarcinoma derived from IPMN / mucinous carcinoma / MUC5AC

Research Abstract

Most of the cases of pancreatic adenocarcinoma derived from IPMN were derived from intestinal type IPMN. As for the pattern of invasion in pancreatic carcinoma, most advanced pancreatic cancers revealed a mixed replacement pattern(interlobular replacement pattern and intralobular replacement pattern) as well as a haphazard growth pattern. Entrapped normal pancreatic structures within the area of invasive carcinoma were easily and clearly identified by using triple immunostains. The distribution or the extent of such entrapped normal cells differed depending on the cases.

Research Products

• [Journal Article] Prognostic relevance of morphological types of intraductal papillary mucinous neoplasms of the pancreas (2011)
  • Author(s): Furukawa T, Hatori T, Fujita I, Yamamoto M, Kpbayashi M, Ohike N, Morhoshi T, Egawa S, Unno M, Takao S, Osako M, Yonezawa S, Mino-Kenudson M, Lauwers GY, Yamaguchi H, Ban S, Shimizu M
  • Journal Title: Gut Volume: 60 Pages: 509-516
  • Peer Reviewed
• [Journal Article] Invasive ductal carcinoma of the pancreas tail with noninvasive growth through the nondilated main pancreatic duct and macroscopically cystic invasive carcinomatous glands (2011)
  • Author(s): Ban S, Satoh H, Satoh M, Ishido Y, Nakayama N, Yamaguchi H, Shimizu M
  • Journal Title: Ann Diagn Pathol Volume: 15 Pages: 476-480
  • Peer Reviewed
• [Journal Article] Pancreatic intraductal lesions with possible relationship with gastric type intraductal papillary mucinous neoplasm : pyloric gland-type intra-ductal tubular adenoma and intraductal oncocytic papillary neoplasm (2010)
  • Author(s): Ban S
  • Journal Title: Histopathology Volume: 56 Pages: 968-969
  • Peer Reviewed
• [Journal Article] Pancreatic intraductal lesions with possible relationship with gastric type intraductal papillary mucinous neoplasm : pyloric gland-type intraductal tubular adenoma and intraductal oncocytic papillary neoplasm (2009)
  • Author(s): Ban S, Yamaguchi H, Shimizu M
  • Journal Title: Histopathology Volume: 55 Pages: 270-276
  • Peer Reviewed
• [Journal Article] Small invasive ductal adenocarcinoma of the pancreas associated with lymphoplasmacytic sclerosing pancreatitis (2009)
  • Author(s): Motosugi U, Ichikwawa T, Yamaguchi H, Nakazawa T, Katoh R, Itakura J, Fujii H, Sato T, Araki T, Shimizu M
  • Journal Title: Pathol Int Volume: 59 Pages: 744-747
  • NAID: 10027381949
  • Peer Reviewed
• [Journal Article] CD133 expression pattern distinguishes intraductal papillary mucinous neoplasmas from ductal adenocarcinomas of the pancreas (2009)
  • Author(s): Shimizu K, Itoh T, Shimizu M, Hori Y
  • Journal Title: Pancreas Volume: 38
  • Peer Reviewed
• [Journal Article] Detection of lymphatic invasion in resected cases of primary pancreatic cancer based on immunohistochemistry of D2-40 (2009)
  • Author(s): Shimizu Y, Jin L, Yamaguchi H, Morosugi U, Sannohe S, Nagata K, Sakurai T, Murata S, Yasuda M, Shimizu M
  • Journal Title: Ann Diagn Pathol Volume: 13 Pages: 168-172
  • Peer Reviewed
• [Journal Article] Intraductal tubulopapillary neoplasms of the pancreas distinct from pancreatic intraepithelial and intraductal papillary mucinous neoplasms (2009)
  • Author(s): Yamaguchi H, Shimizu M, Ban S, Koyama I, Haroti T, Fujita I, et al
  • Journal Title: Am J Surg Pathol Volume: 33 Pages: 1164-1172
  • Peer Reviewed
• [Journal Article] Intraductal tubulopapillary neoplasms of the pancreas distinct from pancreatic intraepithelial and intraductal papillary mucinous neoplasms (2009)
  • Author(s): Yamaguchi H
  • Journal Title: Am J Surg Pathol 33 Pages: 1164-1172
  • Peer Reviewed
• [Journal Article] Detection of lymphatic invasion in resected cases of primary pancreatic cancer based on immunohistochemistry of D2-40 (2009)
  • Author(s): Shimizu Y
  • Journal Title: Ann Diagn Pathol 13 Pages: 168-172
  • Peer Reviewed
• [Journal Article] CD133 expression pattern distinguishes intraductal papillary mucinous neoplasmas from ductal adenocarcinomas of the pancreas (2009)
  • Author(s): Shimizu K
  • Journal Title: Pancreas 38
  • Peer Reviewed
• [Journal Article] Invasive ductal carcinoma of the pancreas tail with noninevasive growth through the nondilated main pancreatic duct and macroscopically cystic invasive carcinomatous glands
  • Author(s): Ban S
  • Journal Title: Ann Diagn Pathol Volume: Nov 23(Epub ahead of print)
  • Peer Reviewed
• [Presentation] Triple immunostains for assessment of invasive patterns of pancreatic carcinoma (2011)
  • Author(s): Shimizu M
  • Organizer: 4th Asian-Oceanic Pancreas Association
  • Place of Presentation: Korea, Jeju
  • Year and Date: 2011-09-02
• [Presentation] Triple immunostains for assessment of invasive patterns of pancreatic carcinoma (2011)
  • Author(s): Shimizu M
  • Organizer: 4^<th> Asian-Oceanic Pancreas Association
  • Place of Presentation: Jeju, Korea
  • Year and Date: 2011-09-02
• [Presentation] Invasive and growth patterns of ductal carcinoma of the pancreas : early versus advanced stage (2010)
  • Author(s): Shimizu M
  • Organizer: The Pathologists' Meeting CAP 2010
  • Place of Presentation: U. S. A, Chicago
  • Year and Date: 2010-09-26
• [Presentation] Invasive and growth patterns of ductal carcinoma of the pancreas : early versus advanced stage (2010)
  • Author(s): Shimizu M
  • Organizer: The Pathologists's Meeting CAP (College of American Pathologists) 2010
  • Place of Presentation: Chicago
  • Year and Date: 2010-09-26
• [Presentation] 免疫三重染色を用いた膵管癌の浸潤様式に関する検討 (2010)
  • Author(s): 清水道生
  • Organizer: 第57回日本臨床検査医学会学術集会
  • Place of Presentation: 東京,京王プラザホテル
  • Year and Date: 2010-09-11
• [Presentation] 免疫三重染色を用いた膵管癌の浸潤様式に関する検討 (2010)
  • Author(s): 清水道生
  • Organizer: 第57回日本臨床検査医学会学術集会
  • Place of Presentation: 東京,京王プラザ
  • Year and Date: 2010-09-11
• [Presentation] 膵臓のPanIN病変とIPMN :その相互関係とpathwayについて (2009)
  • Author(s): 清水道生
  • Organizer: 第56回日本臨床検査医学会学術集会
  • Place of Presentation: 北海道,札幌コンベンションセンター
  • Year and Date: 2009-08-27
• [Presentation] 膵臓のPanIN病変とIPMN:その相互関係と pathway について (2009)
  • Author(s): 清水道生
  • Organizer: 第56回日本臨床検査医学会学術集会
  • Place of Presentation: 札幌コンベンションセンター
  • Year and Date: 2009-08-27
• [Book] 病理医・臨床医のための病理診断アトラス."彩の国さいたま"病理診断セミナーからのメッセージ (2009)
  • Author(s): 清水道生
  • Publisher: ベクトルコア
• [Book] 病理医・臨床医のための病理診断アトラス."彩の国さいたま"病理診断セミナーからのメッセージ (2009)
  • Author(s): 清水道生
  • Total Pages: 191
  • Publisher: ベクトルコア, 東京, 2009