Cancerization and invasion of pancreatic neoplasm : Toward the approach for targeted therapy
| Project/Area Number |
21590403
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Saitama Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
清水 禎彦 埼玉医科大学, 医学部, 准教授 (20206220)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 診断病理学 / 膵腫瘍 / 膵癌 / ランゲルハンス島 / 免疫組織化学 / 浸潤様式 / 扁平上皮 / p63 / CD44 / 発育様式 / 腺房 / 膵管 / 免疫三重染色 / low-grade PanIN / gastric type IPMN / ITPN / intestinal type IPMN / pancreatic adenocarcinoma / adenocarcinoma derived from IPMN / mucinous carcinoma / MUC5AC |
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| Research Abstract |
Most of the cases of pancreatic adenocarcinoma derived from IPMN were derived from intestinal type IPMN. As for the pattern of invasion in pancreatic carcinoma, most advanced pancreatic cancers revealed a mixed replacement pattern(interlobular replacement pattern and intralobular replacement pattern) as well as a haphazard growth pattern. Entrapped normal pancreatic structures within the area of invasive carcinoma were easily and clearly identified by using triple immunostains. The distribution or the extent of such entrapped normal cells differed depending on the cases.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] Prognostic relevance of morphological types of intraductal papillary mucinous neoplasms of the pancreas2011
Author(s)
Furukawa T, Hatori T, Fujita I, Yamamoto M, Kpbayashi M, Ohike N, Morhoshi T, Egawa S, Unno M, Takao S, Osako M, Yonezawa S, Mino-Kenudson M, Lauwers GY, Yamaguchi H, Ban S, Shimizu M
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Journal Title
Gut
Volume: 60
Pages: 509-516
Related Report
Peer Reviewed
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