Identification of initiating cells of lung adenocarcinoma, analysis of its characteristics and application to therapy of lung adenocarcinoma.

• Project/Area Number: 21590406
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Human pathology
• Research Institution: Juntendo University
• Principal Investigator: ANAMI Yoichi 順天堂大学, 医学部, 准教授 (40317376)
• Co-Investigator(Kenkyū-buntansha): NOGUCHI Masayuki 筑波大学, 医学研究科, 教授 (00198582) ; MATSUOKA Shuji 順天堂大学, 医学部, 助教 (20286743)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 肺腺癌 / tumor-initiating cell / 異型腺腫様過形成病変(AAH) / 細気管支肺胞上皮癌 / Dimethylarginie dimethlaminohydrolase 2(DDAH2) / 肺腺がん / モノクローナル抗体 / 胎児ブタ / がん間質細胞 / DDAH2 / 癌 / 発生・分化 / 病理学 / ゲノム / 遺伝子

Research Abstract

Mouse monoclonal antibodies were developed using normal seventh gestational week fetuses of miniature swine as antigen. Eleven clones reacted against fetal lung tissue and lung adenocarcinoma specifically. Among the 11 clones, one clone reacted against tumor stroma specifically and the antigen recognized by the antibody was Dimethylarginine dimethylaminohydrolase(DDAH2).

Research Products

• [Journal Article] Aberrant stratifin overexpression is regulated by tumor-associated CpG demethylation in lung adenocarcinoma (2012)
  • Author(s): Shiba-Ishii A, Noguchi M
  • Journal Title: Am J Pathol Volume: 180 Pages: 1653-1662
  • Peer Reviewed
• [Journal Article] Abnormality of the hepatocyte growth factor/MET pathway in pulmonary adenocarcinogenesis (2012)
  • Author(s): Tachibana K, Minami Y, Shiba-Ishii A, Kano J, Nakazato Y, Sato Y, Goya T, Noguchi M
  • Journal Title: Lang Cancer Volume: 75 Pages: 181-188
  • Peer Reviewed
• [Journal Article] Hepatocyte growth factor expression in EGFR mutant lung cancer with intrinsic and acquired resistance to tyrosine kinase inhibitors in a Japanese cohort (2011)
  • Author(s): Yano S, Yamada T, Takeuchi S, Tachibana K, Minami Y, Yatabe Y, Mitsudomi T, Tanaka H, Kimura T, Kudoh S, Nokihara H, Ohe Y, Yokota J, Uramoto H, Yasumoto K, Kiura K, Higashiyama M, Oda M, Saito H, Yoshida J, Kondoh K, Noguchi M
  • Journal Title: J Thorac Oncol Volume: 6 Pages: 2011-2017
  • Peer Reviewed
• [Journal Article] International association for the study of lung cancer/American Thoracic Society/European Respiratory Society : international multidisciplinary classification of lung adenocarcinoma : executive summary (2011)
  • Author(s): Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger K, Yatabe Y, Powell CA, Beer D, Riely G, Garg K, Austin JH, Rusch VW, Hirsch FR, Jett J, Yang PC, Gould M
  • Journal Title: Proc Am Thorac Soc Volume: 8 Pages: 381-385
  • Peer Reviewed
• [Journal Article] Treatment outcome of adult burkitt lymphoma in Japanese patients with modified LMB protocol : a signal center retrospective analysis (2011)
  • Author(s): Nishikii H, Nakamura N, Kondo Y, Okoshi Y, Suzukawa K, Hasegawa Y, Yokoyama Y, Sakata-Yanagimoto M, Enami T, Noguchi M, Chiba S
  • Journal Title: J Clin Exp Hematopathol Volume: 51 Pages: 109-114
  • Peer Reviewed
• [Journal Article] Reaction of plasma hepatocyte growth factor levels in non-small cell lung cancer patients treated with EGFR-TKIs (2011)
  • Author(s): Tanaka H, Kimura T, Kudoh S, Mitsuoka S, Watanabe T, Suzumura T, Tachibana K, Noguchi M, Yano S, Hirata K
  • Journal Title: Int J Cancer Volume: 129 Pages: 1410-1416
  • Peer Reviewed
• [Journal Article] MYC amplification as a prognostic marker of early stage lung adenocarcinoma identified by whole genome copy number analysis (2011)
  • Author(s): Iwakawa R, Kohno T, Kato M, Shiraishi K, Tsuta K, Noguchi M, Ogawa S, Yokota J
  • Journal Title: Clin Cancer Res Volume: 17 Pages: 1481-1489
  • Peer Reviewed
• [Journal Article] Specific expression of ZO-1 and N-cadherin in rosette structures of various tumors : possible recapitulation of neural tube formation in embryogenesis and utility as a potentially novel immunohistochemical marker of rosette formation in pulmonary neuroendocrine tumors (2011)
  • Author(s): Satomi K, Morishita Y, Sakashita S, Kondou Y, Furuya S, Minami Y, Noguchi M
  • Journal Title: Virchows Arch Volume: 459 Pages: 399-407
  • Peer Reviewed
• [Journal Article] IGFBP-1 is expressed specifically in ovarian clear cell adenocarcinoma (2011)
  • Author(s): Sugita S, Morishita Y, Kano J, Furuya S, Shiba-Ishii A, Noguchi M
  • Journal Title: Histopathology Volume: 58 Pages: 729-738
  • Peer Reviewed
• [Journal Article] International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma (2011)
  • Author(s): Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, SaijoN, Thunnissen E, Tsao M, Yankelewitz D
  • Journal Title: J Thorac Oncol Volume: 6 Pages: 244-285
  • Peer Reviewed
• [Journal Article] APAF-1 is related to an undifferentiated state in the testicular germ cell tumor pathway (2011)
  • Author(s): Behjati R, Kawai K, Inadome Y, Kano J, Akaza H, Noguchi M
  • Journal Title: Cancer Science Volume: 102 Pages: 267-274
  • NAID: 10029289415
  • Peer Reviewed
• [Journal Article] Binding of lactoferrin to IGBP1 triggers apoptosis in a lung adenocarcinoma cell line (2011)
  • Author(s): Li D, Sakashita S, Morishita Y, Kano J, Shiba-Ishii A, Sato T, Noguchi M
  • Journal Title: Anticancer Res Volume: 31 Pages: 529-534
  • Peer Reviewed
• [Journal Article] Overexpression of immunoglobulin(CD79a) binding protein1(IGBP-1) in small lung adenocarcinomas and its clinicopathological significance (2011)
  • Author(s): Sakashita S, Li D, Nashima N, Minami Y, Furuya S, Morishita Y, Tachibana K, Sato Y, Noguchi M
  • Journal Title: Pathol Int Volume: 61 Pages: 130-137
  • NAID: 10031185061
  • Peer Reviewed
• [Journal Article] High expression of Stratifin is a universal abnormality during the course of malignant progression of early-stage lung adenocarcinoma (2011)
  • Author(s): Shiba-Ishii A, Kano J, Morishita Y, Sato Y, Minami Y, Noguchi M
  • Journal Title: Int J Cancer Volume: 129 Pages: 2445-2453
  • Peer Reviewed
• [Journal Article] Overexpression of immunoglobulin (CD79a) binding protein 1 (IGBP-1) in small lung adenocarcinomas and its clinicopathological significance (2011)
  • Author(s): Sakashita S
  • Journal Title: Pathol Int Volume: 61 Pages: 130-137
  • Peer Reviewed
• [Journal Article] Expression of the GA733 gene family and its relationship to prognosis in pulmonary adenocarcinoma (2010)
  • Author(s): Kobayashi H, Minami Y, Anami Y, Kondou Y, Iijima T, Kano J, Morishita Y, Tsuta K, Hayashi S, Noguchi M
  • Journal Title: Virchows Arch Volume: 457 Pages: 69-76
  • Peer Reviewed
• [Journal Article] Nuclear Grading of Primary Pulmonary Adenocarcinomas-Correlation of nuclear size with prognosis- (2010)
  • Author(s): Nakazato Y, Minami Y, Kobayashi H, Satomi K, Anami Y, Tsuta K, Tanaka R, Okada M, Goya T, Noguchi M
  • Journal Title: Cancer Volume: 116 Pages: 2011-2019
  • Peer Reviewed
• [Journal Article] Increased cytoplasmic S100A6 expression is associated with pulmonary adenocarcinoma progression (2009)
  • Author(s): Ishii A, Suzuki M, Satomi K, Kobayashi H, Sakashita S, Kano J, Pei Y, Minami Y, Ishikawa S, Noguchi M
  • Journal Title: Pathol Int Volume: 59 Pages: 623-30
  • NAID: 10027381414
  • Peer Reviewed
• [Journal Article] Bronchioloalveolar carcinoma(lepidic growth) component is a more useful prognostic factor than lymph node metastasis (2009)
  • Author(s): Anami Y, Iijima T, Suzuki K, Yokota J, Minami Y, Kobayashi H, Satomi K, Nakazato Y, Okada M, Noguchi M
  • Journal Title: J Thorac Oncol Volume: 4 Pages: 951-958
  • NAID: 40016950207
  • Peer Reviewed
• [Journal Article] Overexpression of Dickkopf 3 in hepatoblastomas and hepatocellular carcinomas (2009)
  • Author(s): Pei Y, Kano J, Iijima T, Morishita Y, Inadome Y, Noguchi M
  • Journal Title: Virchows Arch Volume: 454 Pages: 639-46
  • Peer Reviewed
• [Journal Article] Whole genome comparison of allelic imbalance between noninvasive and invasive small-sized lung adenocarcinomas (2009)
  • Author(s): Nakanishi H, Matsumoto S, Iwakawa R, Kohno T, Suzuki K, Tsuta K, Matsuno Y, Noguchi M, Shimizu E, Yokota J
  • Journal Title: Cancer Res Volume: 69 Pages: 1615-1623
  • Peer Reviewed
• [Presentation] 術前気管支鏡、術中針生検で確定診断に至らなかった肺腺癌の1例 (2012)
  • Author(s): 倉持雅己、山岡賢俊、小林敬祐、井口けさ人、菊池慎二、酒井光昭、後藤行延、鬼塚正孝、佐藤幸夫、薄井真悟、南優子、野口雅之
  • Organizer: 第163回日本肺癌学会関東支部会
  • Place of Presentation: 日本教育会館
  • Year and Date: 2012-03-10
• [Presentation] ヒト肺腺癌間質におけるDimethylarginine dimethylaminohydrolase 2(DDAH2)発現の検討 (2011)
  • Author(s): 薄井真悟、山田健二、坂田晃子、南優子、佐藤幸夫、野口雅之
  • Organizer: 第52回日本肺癌学会総会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2011-11-04
• [Presentation] 小型肺腺癌のArray CGH解析 (2011)
  • Author(s): 南優子、村田佳彦、野口雅之
  • Organizer: 第52回日本肺癌学会総会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2011-11-04
• [Presentation] 非小細胞肺癌症例におけるEGFR-TKIs投与と肝細胞増殖因子の応答についての検討 (2011)
  • Author(s): 田中秀典、木村達郎、工藤新三、橘啓盛、野口雅之、矢野聖二、平田一人
  • Organizer: 第51回日本肺癌学会総会
  • Place of Presentation: 広島国際会議場
  • Year and Date: 2011-11-04
• [Presentation] ヒト肺腺癌間質におけるDimethylarginine dimethylaminohydrolase 2 (DDAH2)発現の検討 (2011)
  • Author(s): 薄井真悟
  • Organizer: 第52回日本肺癌学会総会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2011-11-04
• [Presentation] Stiff person症候群を合併した胸腺腫の1切除例 (2011)
  • Author(s): 山岡賢俊、小林尚寛、薄井真悟、菊池慎二、酒井光昭、後藤行延、鬼塚正孝、佐藤幸夫、南優子、野口雅之
  • Organizer: 第52回日本肺癌学会総会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2011-11-03
• [Presentation] 肺の異型腺腫様過形成をターゲットとしたプロテオミクス解析 (2011)
  • Author(s): 坂下信悟、里見介史、鈴木恵子、南優子、野口雅之
  • Organizer: 第52回日本肺癌学会総会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2011-11-03
• [Presentation] 肺神経内分泌腫瘍のロゼット構造における, ZO-1の特異的局在と診断への応用 (2011)
  • Author(s): 里見介史、森下由紀雄、南優子、野口雅之
  • Organizer: 第52回日本肺癌学会総会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2011-11-03
• [Presentation] 悪性胸膜中皮腫に対する生検時胸腔鏡下狭帯域光(NBI : Narrow Band Imaging)観察 (2011)
  • Author(s): 後藤行延、山岡賢俊、小林敬祐、薄井真悟、井口けさ人、倉持雅己、菊池慎二、酒井光昭、鬼塚正孝、佐藤幸夫、南優子、野口雅之
  • Organizer: 第52回日本肺癌学会総会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2011-11-03
• [Presentation] 小型肺腺癌におけるIGBP1発現と組織学的特徴 (2011)
  • Author(s): 坂下信悟、李冬平、南優子、野口雅之
  • Organizer: 第51回日本肺癌学会総会
  • Place of Presentation: 広島国際会議場
  • Year and Date: 2011-11-03
• [Presentation] 悪性胸膜中皮腫に対する生検時胸腔鏡下狭帯域光(NBI:Narrow Band Imaging)観察 (2011)
  • Author(s): 後藤行延
  • Organizer: 第52回日本肺癌学会総会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2011-11-03
• [Presentation] 肺神経内分泌腫瘍のロゼット構造における,ZO-1の特異的局在と診断への応用 (2011)
  • Author(s): 里見介史
  • Organizer: 第52回日本肺癌学会総会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2011-11-03
• [Presentation] 肺腺がんのWHO新分類 (2011)
  • Author(s): 野口雅之
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2011-10-04
• [Presentation] Moesinは子宮腺筋症の浸潤に関与する (2011)
  • Author(s): 大原玲奈、柴綾、里見介史、坂下信悟、加野准子、吉川裕之、野口雅之
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2011-10-03
• [Presentation] 肺腺癌におけるstratifinの発現上昇はプロモーター領域の脱メチル化によって引き起こされる (2011)
  • Author(s): 柴綾、野口雅之、加野准子
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2011-10-03
• [Presentation] 好中球浸潤を伴って主に胞巣状に増殖する核異型の高度な子宮頚部腫瘍の1例 (2011)
  • Author(s): 坂田晃子、上杉憲子、森下由紀雄、野口雅之
  • Organizer: 第26回日本臨床細胞学会茨城県支部学術集会、第32回茨城病院病理医の会
  • Place of Presentation: 筑波大学
  • Year and Date: 2011-09-17
• [Presentation] 子宮頚部小細胞癌の4例 (2011)
  • Author(s): 原田哲也、坂中都子、小曽根浩一、市川良太、大坪保雄、新井ゆう子、西田正人、斎藤広樹、高野克己、永田千草、近藤譲、野口雅之
  • Organizer: 第26回日本臨床細胞学会茨城県支部学術集会、第32回茨城病院病理医の会
  • Place of Presentation: 筑波大学
  • Year and Date: 2011-09-17
• [Presentation] Immunogloblin binding protein 1(IGBP1) is a key protein related to anti-apoptotic activity in lung adenocarcinoma (2011)
  • Author(s): Sakashita S, Li D, Tachibana K, Minami Y, Yoshida T, Sato T, Morishita Y, Noguchi M
  • Organizer: 14^<th> World Conference on Lung Cancer
  • Place of Presentation: Amsterdam, The Netherlands
  • Year and Date: 2011-07-07
• [Presentation] Immunogloblin binding protein 1 (IGBP1) is a key protein related to anti-apoptotic activity in lung adenocarcinoma (2011)
  • Author(s): Sakashita S
  • Organizer: 14^<th> World Conference on Lung Cancer
  • Place of Presentation: Amsterdam
  • Year and Date: 2011-07-07
• [Presentation] Demethylation-induced overexpression of stratifin is a universal abnormality during the progression of lung adenocarcinoma (2011)
  • Author(s): Shiba-Ishii A, Kano J, Noguchi M
  • Organizer: 14^<th> World Conference on Lung Cancer
  • Place of Presentation: Amsterdam, The Netherlands
  • Year and Date: 2011-07-06
• [Presentation] Demethylation-induced overexpression of stratifin is a universal abnormality during the progression of lung adenocarcinoma (2011)
  • Author(s): Shiba-Ishii A
  • Organizer: 14^<th> World Conference on Lung Cancer
  • Place of Presentation: Amsterdam
  • Year and Date: 2011-07-06
• [Presentation] Array CGH analysis of small-sized adenocarcinoma of the lung (2011)
  • Author(s): Minami Y, Murata Y, Noguchi M
  • Organizer: 14^<th> World Conference on Lung Cancer
  • Place of Presentation: Amsterdam, The Netherlands
  • Year and Date: 2011-07-05
• [Presentation] Accuracy of histological non-small cell lung carcinoma subtyping in diagnostic lung (2011)
  • Author(s): Savic S, Glatz K, Kerr KM, Nicholson AG, Noguchi M, Popper HH, Yatabe Y, Travis WD, Bubendorf
  • Organizer: 14^<th> World Conference on Lung Cancer
  • Place of Presentation: Amsterdam, The Netherlands
  • Year and Date: 2011-07-05
• [Presentation] Accuracy of histological non-small cell lung carcinoma subtyping in diagnostic lung (2011)
  • Author(s): Savic S
  • Organizer: 14^<th> World Conference on Lung Cancer
  • Place of Presentation: Amsterdam
  • Year and Date: 2011-07-05
• [Presentation] Array CGH analysis of small-sized adenocarcinoma of the lung (2011)
  • Author(s): Minami Y
  • Organizer: 14^<th> World Conference on Lung Cancer
  • Place of Presentation: Amsterdam
  • Year and Date: 2011-07-05
• [Presentation] Abnormal golml gene expression in adenocarcinoma of the lung (2011)
  • Author(s): Yoshida T, Minami Y, Shiba-Ishii A, Sakashita S, Tachibana K, Nakazato Y, Goya T, Noguchi M
  • Organizer: 14^<th> World Conference on Lung Cancer
  • Place of Presentation: Amsterdam, The Netherlands
  • Year and Date: 2011-07-04
• [Presentation] Interobserver agreement in the nuclear grading of primary pulmonary adenocarcinoma : a collaborative microscopy project (2011)
  • Author(s): Nakazato Y, Maeshima AM, Ishikawa Y, Yatabe Y, Fukuoka J, Yokose T, Tomita Y, Minami Y, Asamura H, Tachibana K, Goya T, Noguchi M
  • Organizer: 14^<th> World Conference on Lung Cancer
  • Place of Presentation: Amsterdam, The Netherlands
  • Year and Date: 2011-07-04
• [Presentation] Reproducibility of invasion in pulmonary adenocarcinoma. An international interobserver study (2011)
  • Author(s): Thunnissen E, Beasly M, Borczuk A, Brambilla E, Chirieac LR, Dacic S, Flieder D, Gazdar AF, Geisinger K, Ishikawa Y, Kerr KM, Minami Y, Lantejoul S, Matsuno Y, Moreira AL, Motoi N, Nicholson AG, Noguchi M, Nonaka D, Pelosi G, Peterson I, Rekhtman N, Roggli VL, Travis WD, Tsao MS, Wistuba I, Xu H, Yatabe Y, Kuik DJ
  • Organizer: 14^<th> World Conference on Lung Cancer
  • Place of Presentation: Amsterdam, The Netherlands
  • Year and Date: 2011-07-04
• [Presentation] Molecular pathogenesis of adenocarcinoma and its precursor lesions (2011)
  • Author(s): Noguchi M
  • Organizer: 14^<th> World Conference on Lung Cancer
  • Place of Presentation: Amsterdam, The Netherlands
  • Year and Date: 2011-07-04
• [Presentation] Molecular pathogenesis of adenocarcinoma and its precursor lesions (2011)
  • Author(s): Noguchi M
  • Organizer: 14^<th> World Conference on Lung Cancer
  • Place of Presentation: Amsterdam
  • Year and Date: 2011-07-04
• [Presentation] Reproducibility of invasion in pulmonary adenocarcinoma. An international interobserver study (2011)
  • Author(s): Thunnissen E
  • Organizer: 14^<th> World Conference on Lung Cancer
  • Place of Presentation: Amsterdam
  • Year and Date: 2011-07-04
• [Presentation] Interobserver agreement in the nuclear grading of primary pulmonary adenocarcinoma : a collaborative microscopy project (2011)
  • Author(s): Nakazato Y
  • Organizer: 14^<th> World Conference on Lung Cancer
  • Place of Presentation: Amsterdam
  • Year and Date: 2011-07-04
• [Presentation] Abnormal golm1 gene expression in adenocarcinoma of the lung (2011)
  • Author(s): Yoshida T
  • Organizer: 14^<th> World Conference on Lung Cancer
  • Place of Presentation: Amsterdam
  • Year and Date: 2011-07-04
• [Presentation] 左S6過分葉肺の臓側胸膜から発生した孤立性繊維性腫瘍の1例 (2011)
  • Author(s): 小林敬祐、山岡賢俊、井口けさ人、菊池慎二、倉持雅巳、後藤行延、酒井光昭、鬼塚正孝、佐藤幸夫、薄井真悟、南優子、野口雅之
  • Organizer: 第161回日本肺癌学会関東支部会
  • Place of Presentation: 京王プラザホテル
  • Year and Date: 2011-06-18
• [Presentation] Atypical teratoid/rhabdoid tumorにおける上皮成長因子受容体の検討 (2011)
  • Author(s): 里見介史、柴綾、村田佳彦、森下由紀雄、南優子、野口雅之
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2011-04-30
• [Presentation] Dimethylarginine dimethylaminohydrolase 2(DDAH2)のヒト肺腺癌間質における発現の特徴 (2011)
  • Author(s): 山田健二、戸嶋章太郎、坂田晃子、稲留征典、野口雅之
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2011-04-28
• [Presentation] 肺腺癌初期悪性化過程における抗アポトーシス蛋白質の発現 (2011)
  • Author(s): 坂下信悟、南優子、村田佳彦、古屋周一郎、永田千草、森下由紀雄、鈴木恵子、野口雅之
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2011-04-28
• [Presentation] 乳癌HER2過剰発現判定の個人差の検討-特に病理経験年数との関係について- (2011)
  • Author(s): 飯嶋達雄、近藤譲、斉藤仁昭、野上達也、内田好明、常松一恵、阿部香織、新発田雅晴、石井愛美、土井幹雄、野口雅之
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2011-04-28
• [Presentation] 肺腺癌症例におけるGOLM1遺伝子発現の特徴 (2011)
  • Author(s): 吉田勤、南優子、柴綾、中里宜正、野口雅之
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2011-04-28
• [Presentation] Dimethylarginine dimethylaminohydrolase 2 (DDAH2)のヒト肺腺癌間質における発現の特徴 (2011)
  • Author(s): 山田健二
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2011-04-28
• [Presentation] Pulmonary adenocarcinoma : current concepts and updates (2010)
  • Author(s): Noguchi M. Pulmonary adenocarcinoma
  • Organizer: 4^<th> Asia Pacific Lung Cancer Conference(第4回アジア・太平洋肺癌学会)
  • Year and Date: 2010-12-03
• [Presentation] つくばヒト組織診断センター(Tsukuba Human Tissue Diagnostic Center, THDC)の試み.シンポジウム-2病理診断体制の現状と今後のあり方 (2010)
  • Author(s): 野口雅之
  • Organizer: 第56回日本病理学会秋期特別総会
  • Place of Presentation: 西日本展示場
  • Year and Date: 2010-11-26
• [Presentation] 血清CA19-9高値を呈した縦隔成熟奇形腫の1切除例 (2010)
  • Author(s): 鈴木久史、大野智之、福岡俊彦、菅野雅人、森下由紀雄、野口雅之
  • Organizer: 第51回日本肺癌学会総会
  • Place of Presentation: 広島国際会議場
  • Year and Date: 2010-11-04
• [Presentation] 肺腺癌におけるLfのanti-apoptotic機能 (2010)
  • Author(s): 李冬平、森下由紀雄、佐藤泰樹、坂下信悟、柴綾、南優子、野口雅之
  • Organizer: 第51回日本肺癌学会総会
  • Place of Presentation: 広島国際会議場
  • Year and Date: 2010-11-04
• [Presentation] 肺神経内分泌腫瘍のロゼット構造における, ZO-1の特異的発現 (2010)
  • Author(s): 里見介史、森下由紀雄、南優子、野口雅之
  • Organizer: 第51回日本肺癌学会総会
  • Place of Presentation: 広島国際会議場
  • Year and Date: 2010-11-03
• [Presentation] 核グレードを利用した小型肺腺癌の悪性度評価における観察者間変動の検討 (2010)
  • Author(s): 中里宜正、前島亜希子、谷田部恭、富田裕彦、横瀬智之、石川雄一、福岡順也、浅村尚生、呉屋朝幸、橘啓盛、南優子、野口雅之
  • Organizer: 第51回日本肺癌学会総会
  • Place of Presentation: 広島国際会議場
  • Year and Date: 2010-11-03
• [Presentation] 小型肺腺癌におけるMET遺伝子コピー数とHepatocyte growth factor, MET発現解析 (2010)
  • Author(s): 橘啓盛、南優子、柴綾、吉田勤、中里宜正、佐藤幸夫、呉屋朝幸、野口雅之
  • Organizer: 第51回日本肺癌学会総会
  • Place of Presentation: 広島国際会議場
  • Year and Date: 2010-11-03
• [Presentation] 微小浸潤肺腺癌診断の再現性の検証 (2010)
  • Author(s): 南優子、中里宜正、石川雄一、谷田部恭、柿沼龍太郎、野口雅之
  • Organizer: 第51回日本肺癌学会総会
  • Place of Presentation: 広島国際会議場
  • Year and Date: 2010-11-03
• [Presentation] Effect of APAF-1 down-regulation on the cell morphology and proliferation rate of testicular germ cell tumor cell lines (2010)
  • Author(s): Behjati R, Kawai K, Inadome Y, Kano J, Shiba-Ishii A, Shimazui T, Noguchi M
  • Organizer: 69^<th> Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Osaka
  • Year and Date: 2010-09-24
• [Presentation] 肺神経内分泌腫瘍のロゼット構造におけるZO-1発現の検討 (2010)
  • Author(s): 里見介史、森下由紀雄、南優子、野口雅之
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2010-09-24
• [Presentation] MYC過増幅と早期肺腺がん患者の予後との関連性 (2010)
  • Author(s): 岩川麗香、河野隆志、加藤元博、松原亜以子、白石航也、蔦幸治、野口雅之、小川誠司、横田淳
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2010-09-23
• [Presentation] 肺腺癌細胞におけるラクトフェリンとIGBP1の結合によるアポトーシスの誘導 (2010)
  • Author(s): 李冬平、森下由紀雄、佐藤泰樹、野口雅之
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2010-09-23
• [Presentation] 新規糖鎖解析技術を駆使した肺がん糖鎖バイオマーカー候補分子の同定 (2010)
  • Author(s): 松崎英樹、岩城隼、平尾嘉利、安部美奈子、栂谷内晶、久野敦、大倉隆司、梶裕之、野村将春、野口雅之、池原譲、成松久
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2010-09-22
• [Presentation] Stratifinの発現上昇は早期肺腺癌の悪性化に関与する (2010)
  • Author(s): 柴綾、野口雅之
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2010-09-22
• [Presentation] WHO病理組織分類の改訂について(主に腺癌) (2010)
  • Author(s): 野口雅之
  • Organizer: 第25回日本肺癌学会ワークショップ
  • Place of Presentation: 国立がん研究センター
  • Year and Date: 2010-07-03
• [Presentation] 急性リンパ性白血病再発後、亜急性連合変性症を合併したダウン症候群の1剖検例 (2010)
  • Author(s): 里見介史、松岡健太郎、大喜多肇、森下由紀雄、野口雅之、吉田眞理、中川温子
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 京王プラザホテル
  • Year and Date: 2010-04-29
• [Presentation] 免疫染色結果判定の精度管理に対するバーチャルスライド活用の有用性についての検討 (2010)
  • Author(s): 飯嶋達生、近藤譲、斉藤仁昭、野上達也、内田好明、常松一恵、阿部香織、新発田雅晴、土井幹雄、野口雅之
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 京王プラザホテル
  • Year and Date: 2010-04-29
• [Presentation] Epithelial to mesenchymal transitionによって発生したと考えられる胃の癌肉腫の1例 (2010)
  • Author(s): 坂下信悟、森下由紀雄、柴綾、菅野雅人、里見介史、野口雅之
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 京王プラザホテル
  • Year and Date: 2010-04-29
• [Presentation] 子宮頸部細胞診におけるLBC法の特徴-SurePath(BD社)とTACAS(MBL社)の比較- (2010)
  • Author(s): 深沢政勝、藤原広美、倉田美由紀、村田佳彦、沖明典、佐藤豊実、松本浩司、岡田智志、小貫麻美子、森下由紀雄、杉田真太朗、南優子、野口雅之
  • Organizer: 第25回日本臨床細胞学会茨城県支部学術集会
  • Place of Presentation: 茨城県医師会
  • Year and Date: 2010-03-27
• [Presentation] Histological and immunohistochemical identification of minimally invasive adenocareinoma (2010)
  • Author(s): Noguchi M
  • Organizer: 22^<nd> International Conference on Screening for Lung Cancer.(第22回国際肺癌CT検診会議)
  • Year and Date: 2010-03-19
• [Presentation] 肺癌診療50年の総括と将来展望:病理・病態.特別企画(1)肺癌診療50年の総括と将来展望I (2009)
  • Author(s): 野口雅之
  • Organizer: 第50回日本肺癌学会総会
  • Place of Presentation: 京王プラザホテル
  • Year and Date: 2009-11-12
• [Presentation] Stratifin Facilitates Cell Proliferation of Human Small Lung Adenocarcinoma via the IGF-1-PI3K/AKT Pathway (2009)
  • Author(s): Shiba-Ishii A, Noguchi M
  • Organizer: The 19^<th> HCS-The 3^<rd> Three Universities' Consortium International Symposium(第19回広島がんセミナー)
  • Place of Presentation: 広島国際会議場
  • Year and Date: 2009-11-01
• [Presentation] Pathology and Staging of BAC (2009)
  • Author(s): Noguchi M
  • Organizer: The 19^<th> Biennial Congress of the Association of Thoracic and Cardiovascular Surgeons of Asia in conjunction with The 41^<st> Annual Meeting of Korea Society for Thoracic and Cardiovascular Surgery.(アジア胸部心臓血管外科学会)
  • Place of Presentation: Sheraton Grande Walkhill(ソウル)
  • Year and Date: 2009-10-25
• [Presentation] 肺非小細胞,特に腺癌の組織分類と生物学 (2009)
  • Author(s): 野口雅之
  • Organizer: 第89回北海道医学大会、肺癌・呼吸器内視鏡合同分科会(第35回日本肺癌学会北海道支部会、第31回日本呼吸器内視鏡学会北海道支部会)
  • Place of Presentation: 札幌医科大学記念ホール
  • Year and Date: 2009-10-17
• [Presentation] StratifinはPI3K/Akt pathwayを介して初期肺腺癌の増殖能を亢進させる (2009)
  • Author(s): 石井綾、加野准子、小林弘美、橘啓盛、南優子、野口雅之
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2009-10-03
• [Presentation] 卵巣粘液性腫瘍におけるOCIAD2の発現解析 (2009)
  • Author(s): 永田千草、小林弘美、南優子、森下由紀雄、野口雅之
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2009-10-02
• [Presentation] 肺腺癌細胞株および肺腺癌組織におけるシアリルTnキャリアタンパク質の同定 (2009)
  • Author(s): 安藤秀信、尾崎秀徳、白川彩弓、板谷純、福岡順也、南優子、野村将春、野口雅之、栂谷内晶、佐藤隆、池原譲、成松久
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2009-10-01
• [Presentation] 肺癌手術例における開胸時胸腔洗浄細胞診擬陽性例の検討 (2009)
  • Author(s): 後藤行延、小林敬祐、酒井光昭、石川成美、鬼塚正孝、深沢政勝、南優子、森下由紀雄、野口雅之
  • Organizer: 第50回日本臨床細胞学会総会
  • Place of Presentation: 京王プラザホテル
  • Year and Date: 2009-06-27
• [Presentation] 肺腺癌の組織分類の現状と今後.シンポジウム1.肺腺癌の分子生物学から臨床まで (2009)
  • Author(s): 野口雅之
  • Organizer: 第50回日本臨床細胞学会総会
  • Place of Presentation: 京王プラザホテル
  • Year and Date: 2009-06-27
• [Presentation] Possible delayed cut-end recurrence after limited resection for ground-glass opacity adenocarcinoma, intraoperatively diagnosed as Noguchi Type B, in three patients (2009)
  • Author(s): Yoshida J, Ishii G, Yokose T, Aokage K, Hishida T, Nishimura M, Onuki T, Noguchi M, Nagai K
  • Organizer: 13^<th> World Conference on Lung Cancer
  • Place of Presentation: San Francisco, CA, USA
• [Presentation] Nuclear grading of primary pulmonary adenocarcinomas-correlation between nuclear size and prognosis (2009)
  • Author(s): Nakazato Y, Minami Y, Kobayashi H, Satomi K, Anami Y, Tsuta K, Goya T, Noguchi M
  • Organizer: 13^<th> World Conference on Lung Cancer
  • Place of Presentation: San Francisco, CA, USA
• [Presentation] In situ status, invasion, and extension as prognostic factors in adenocarcinoma (2009)
  • Author(s): Noguchi M
  • Organizer: 13^<th> World Conference on Lung Cancer
  • Place of Presentation: San Francisco, CA, USA
• [Presentation] The new IASLC/ATS/ERS international multidisciplinary lung adenocarcinoma classification (2009)
  • Author(s): Travis WD, Brambilla E, Noguchi M, Geisinger K, Beer D, Powell CA, Johnson B, Riely GJ, Rusch V, Asamura H, Garg K, Austin J, Aberie D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Hirsch F, Hube RM, Ishikawa Y, Jett J, Kerr K, Johnson D, Kuriyama K, Lee JS, Miller V, Mitsudomi T, Nicholson A, Peterson I, Roggli V, Rosell R, Saijo N, Sanchez-Cespedes M, Scagliotti G, Sculier JP, Takahashi T, Thunnissen E, Tsao M, Tsuboi M, Van Schil PE, Vansteenkiste J, Yatabe Y, Wistuba I, Yang PC
  • Organizer: 13^<th> World Conference on Lung Cancer
  • Place of Presentation: San Francisco, CA, USA
• [Presentation] 異所性骨組織と連続した右腋窩の微小な骨外性間葉型軟骨肉腫の一例 (2009)
  • Author(s): 杉田真太朗、森下由紀雄、富樫真二、野口雅之
  • Organizer: 第98回日本病理学会総会
• [Presentation] 悪性肝腫瘍におけるdickkopf3の発現とその診断応用 (2009)
  • Author(s): 裴一花、加野准子、稲留征典、飯嶋達生、森下由紀雄、野口雅之
  • Organizer: 第98回日本病理学会総会
• [Presentation] S100A6は進行肺腺癌で高発現し、組織亜型特異的染色性を示す (2009)
  • Author(s): 石井綾、里見介史、坂下信悟、加野准子、野口雅之
  • Organizer: 第98回日本病理学会総会
• [Presentation] 再発性リンパ腫と二次原発性リンパ腫:組織学的鑑別の限界とその解決についての検討 (2009)
  • Author(s): 志水裕昭、古屋周一郎、近藤譲、野口雅之
  • Organizer: 第98回日本病理学会総会
• [Presentation] バーチャルスライドを用いた免疫染色結果判定の試み一乳癌症例のHER2判定を例として- (2009)
  • Author(s): 近藤譲、飯嶋達生、野口雅之
  • Organizer: 第98回日本病理学会総会
• [Presentation] 肺腺癌組織分類の今後.コンパニオンミーティング5.日本肺病理学会JPPS学術集会「WHO肺癌分類改訂の課題」 (2009)
  • Author(s): 野口雅之
  • Organizer: 第98回日本病理学会総会
• [Presentation] Analysis of APAF-1 expression in the testicular germ cell tumor tissue and germ cell tumor cell lines
  • Author(s): Behjati R, Inadome Y, Kawai K, Akaza H, Noguchi M
  • Organizer: 68^<th> Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Yokohama
• [Book] 肺癌診療Q & A一つ上を行く診療の実践 (2011)
  • Author(s): 石川雄一、野口雅之
  • Publisher: 中外医学社
• [Book] Chapter 26 Pulmonary Neoplasm. In : Sternberg SS, ed. Diagnostic Surgical Pathology. 5th Edition, Philadelphia (2009)
  • Author(s): Noguchi M, Shimosato Y