| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
Gut has a tendency to show the immune tolerance towards the food antigen and the microbial flora. On the other hand, gut shows the active immune responses to prevent the attack of the pathogenic microbe and the harmful antigen. Imbalance of these immune reactions leads to the serious gut disorders like the inflammatory bowel diseases and food allergy. To elucidate the mechanisms of the maintenance of gut immune homeostasis, we generated a murine model showing the immune tolerance for the orally administered ovalbumin. By using this model, we obtained a result that some populations in the spleen are critical for the regulation of gut immune system.
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