Functional analysis of transcription factor ELF2 and investigation of its prognostic significance

• Project/Area Number: 21590412
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Human pathology
• Research Institution: Research Institute, Osaka Medical Center for Cancer and Cardiovascular Disaeses
• Principal Investigator: TOMITA Yasuhiko 地方独立行政法人大阪府立病院機構大阪府立成人病センター(研究所), 病理・細胞診断科, 主任部長 (60263266)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 分子病理 / 転写因子 / 機能解析 / 予後因子

Research Abstract

To investigate the function of PBX1 family and ELF2, transcription factors of metastasis-related molecule VCP, the present study was employed. Analysis of patients with lung cancer, esophageal cancer, and gastric cancer revealed the prognostic significance of PBX2.cDNA microarray analysis using pancreatic cancer cell line revealed the decrease of mitochondrial gene expression by Meis1 siRNA transfection, but not by PBX1, PBX2, Prep1, and ELF2 siRNA transfction.

Research Products

• [Journal Article] Perineural invasion and lymph node involvement as indicators of surgical outcome and pattern of recurrence in the setting of preoperative gemcitabine-based chemoradiation therapy for resectable pancreatic cancer (2012)
  • Author(s): Takahashi H, Ohigashi H, Ishikawa O, Gotoh K, Yamada T, Nagata S, Tomita Y, Eguchi H, Doki Y, Yano M
  • Journal Title: Ann Surg Volume: 255 Issue: 1 Pages: 95-102
  • DOI: 10.1097/sla.0b013e31823d813c
  • Peer Reviewed
• [Journal Article] Role of Meis1 in mitochondrial gene transcription of pancreatic cancer cells (2011)
  • Author(s): Tomoeda M, Yuki M, Kubo C, Yoshizawa H, Kitamura M, Nagata S, Nishizawa Y, Tomita Y
  • Journal Title: Biochem Biophys Res Commun Volume: 410 Issue: 4 Pages: 798-802
  • DOI: 10.1016/j.bbrc.2011.06.066
  • Peer Reviewed
• [Journal Article] Ep-CAM is a significant prognostic factor in pancreatic cancer patients by suppressing cell activity (2011)
  • Author(s): Akita H, Nagano H, Takeda Y, Eguchi H, Wada H, Kobayashi S, Marubashi S, Tanemura M, Takahashi H, Ohigashi H, Tomita Y, Ishikawa O, Mori M, Doki Y
  • Journal Title: Oncogene Volume: 30 Issue: 31 Pages: 3468-76
  • DOI: 10.1038/onc.2011.59
  • Peer Reviewed
• [Journal Article] Influential factors in procedure time of endoscopic submucosal dissection for gastric cancer with fibrotic change (2011)
  • Author(s): Nagata S, Jin YF, Tomoeda M, Kitamura M, Yuki M, Yoshizawa H, Kubo C, Ito Y, Uedo N, Ishihara R, Iishi H, Tomita Y
  • Journal Title: Dig Endosc Volume: 23 Issue: 4 Pages: 296-301
  • DOI: 10.1111/j.1443-1661.2011.01148.x
  • Peer Reviewed
• [Journal Article] KIT-negative gastrointestinal stromal tumor of the abdominal soft tissue : a clinicopathologic and genetic study of 10 cases (2011)
  • Author(s): Yamamoto H, Kojima A, Nagata S, Tomita Y, Takahashi S, Oda Y
  • Journal Title: Am J Surg Pathol Volume: 35 Issue: 9 Pages: 1287-95
  • DOI: 10.1097/pas.0b013e3182206f15
  • NAID: 120005107983
  • Peer Reviewed
• [Journal Article] Role of Meis1 in the mitochondrial gene transcription of pancreatic cancer cells (2011)
  • Author(s): Tomoeda M, Tomita Y, et al
  • Journal Title: Biochem.Biophys.Res.Commun. Volume: 410 Pages: 798-802
  • Peer Reviewed
• [Journal Article] Perivascular Epithelioid Cell Neoplasm (PEComa) of the Pancreas Metastasizing to the Liver (2011)
  • Author(s): Nagata S, Tomita Y, et al
  • Journal Title: pancreas Volume: 40 Pages: 1155-1157
  • Peer Reviewed
• [Journal Article] Expression level of Pre B cell leukemia homeobox 2 correlates with poor prognosis of gastric adenocarcinoma and esophageal squamous cell carcinoma (2010)
  • Author(s): Qiu Y, Song B, Zhao G, Deng B, Makino T, Tomita Y, Wang J, Luo W, Doki Y, Aozasa K, Morii E
  • Journal Title: Int J Oncol Volume: 36 Issue: 3 Pages: 651-63
  • DOI: 10.3892/ijo_00000541
  • Peer Reviewed
• [Journal Article] Synovial sarcoma is a stem cell malignancy (2010)
  • Author(s): Naka N, Takenaka S, Araki N, Miwa T, Hashimoto N, Yoshioka K, Joyama S, Hamada K, Tsukamoto Y, Tomita Y, Ueda T, Yoshikawa H, Itoh K
  • Journal Title: Stem Cells Volume: 28 Issue: 7 Pages: 1119-31
  • DOI: 10.1002/stem.452
  • Peer Reviewed
• [Journal Article] Serum CA19-9 alterations during preoperative gemcitabine-based chemoradiation therapy for resectable invasive ductal carcinoma of the pancreas as an indicator for therapeutic selection and survival (2010)
  • Author(s): Takahashi H, Ohigashi H, Ishikawa O, Eguchi H, Gotoh K, Yamada T, Nakaizumi A, Uehara H, Tomita Y, Nishiyama K, Yano M
  • Journal Title: Ann Surg Volume: 251 Issue: 3 Pages: 461-9
  • DOI: 10.1097/sla.0b013e3181cc90a3
• [Journal Article] Synovial Sarcoma is a Stem Cell Malignancy. (2010)
  • Author(s): Naka N, Tomita Y, et al.
  • Journal Title: Stem cells Volume: 28 Pages: 1119-1131
  • Peer Reviewed
• [Journal Article] RB1CC1 activates RB1 pathway and inhibits proliferation and cologenic survival in human cancer. (2010)
  • Author(s): Chano T, Thmita Y, et al.
  • Journal Title: PLoS One. Volume: 5
  • Peer Reviewed
• [Journal Article] Significance of each narrow-band imaging finding in diagnosing squamous mucosal high-grade neoplasia of the esophagus. (2010)
  • Author(s): Ishihara R, Tomita Y, et al.
  • Journal Title: J Gastroenterol Hepatol Volume: 25 Pages: 1410-1405
  • Peer Reviewed
• [Journal Article] Prognostic significance of pre B cell leukemia transcription factor 2(PBX2) expression in non-small cell lung carcinoma (2009)
  • Author(s): Qiu Y, Morii E, Tomita Y, Zhang B, Matsumura A, Kitaichi M, Okumura M, Aozasa K
  • Journal Title: Cancer Sci Volume: 100 Issue: 7 Pages: 1198-209
  • DOI: 10.1111/j.1349-7006.2009.01156.x
  • NAID: 10027191874
  • Peer Reviewed
• [Journal Article] Prognostic significance of phosphorylated FOXO1 expression in soft tissue sarcoma (2009)
  • Author(s): Zhang B, Tomita Y, Chng E, Qiu Y, He J, Jin YF, Tomoeda M, Hamada K, Ueda T, Aozasa K
  • Journal Title: Ann Surg Oncol Volume: 16 Issue: 7 Pages: 1925-37
  • DOI: 10.1245/s10434-009-0481-x
  • Peer Reviewed
• [Journal Article] CD74 is a novel prognostic factor for patients with pancreatic cancer receiving multimodal therapy (2009)
  • Author(s): Nagata S, Jin YF, Yoshizato K, Tomoeda M, Song M, Iizuka N, Kitamura M, Takahashi H, Eguchi H, Ohigashi H, Ishikawa O, Tomita Y
  • Journal Title: Ann Surg Oncol Volume: 16 Issue: 9 Pages: 2531-8
  • DOI: 10.1245/s10434-009-0532-3
  • Peer Reviewed
• [Journal Article] CD74 Is a Novel Prognostic Factor for Patients with Pancreatic Cancer Receiving Multimodal Therapy (2009)
  • Author(s): Nagata S, Tomita Y, et al.
  • Journal Title: Annals of Surgical Oncology 16 Pages: 2531-2538
  • Peer Reviewed
• [Journal Article] Serum REG4 Level Is a Predictive Biomarker for the Response to Preoperative Chemoradiotherapy in Patients With Pancreatic Cancer. (2009)
  • Author(s): Eguchi H, Tomita Y, et al.
  • Journal Title: Pancreas 38 Pages: 791-798
  • NAID: 10027055208
  • Peer Reviewed
• [Journal Article] Prognostic significance of pre B cell leukemia transcription factor 2(PBX2)expression in non-small cell lung carcinoma. (2009)
  • Author(s): Qiu Y, Tomita Y, et al.
  • Journal Title: Cancer Science 100 Pages: 1198-1209
  • NAID: 10027191874
  • Peer Reviewed
• [Presentation] 膵臓細胞診における検体採取と組織型推定に有用な細胞所見IPMNの組織型推定に役立つ細胞所見 (2011)
  • Author(s): 竹中明美、冨田裕彦, 他
  • Organizer: 第52回日本臨床細胞学会春季大会
  • Place of Presentation: 福岡
  • Year and Date: 2011-05-21
• [Presentation] Phosphorylated FOXO1 Is a Novel Prognostic Factor for Patients with Pancreatic Cancer Receiving Multimodal Therapies (2011)
  • Author(s): Jin YF, Tomoeda M, Nagata S, Yoshizato K, Kitamura M, Yuki M, Kubo C, Yoshizawa H, Takahashi H, Ohigashi H, Ishikawa O, Tomita Y
  • Organizer: 100th annual meeting of United States & Canadian Academy of Pathology
  • Place of Presentation: San Antonio, TX, U. S. A.
• [Presentation] Role of Meis1 in the mitochondrial gene transcription of pancreatic cancer cells (2011)
  • Author(s): Tomoeda M, Yuki M, Kubo C, Yoshizawa H, Kitamura M, Nagata S, Nishizawa Y, Tomita Y
  • Organizer: 100th annual meeting of United States & Canadian Academy of Pathology
  • Place of Presentation: San Antonio, TX, U. S. A.
• [Presentation] 貯留胆汁細胞診判定基準は膵領域にも有効か膵液細胞診断における「貯留胆汁細胞診の細胞判定基準」の応用と検討 (2010)
  • Author(s): 竹中明美, 冨田裕彦
  • Organizer: 第49回日本臨床細胞学会秋期大会
  • Place of Presentation: 神戸ポートピアホテル
  • Year and Date: 2010-11-21
• [Presentation] Impact of glutathione S-transferase P1(GSTP1) polymorphisms on survival of patients with unresectable pancreatic cancer receiving multimodal therapies (2010)
  • Author(s): Jin YF, Ioka T, Song M, Tomoeda M, Nagata S, Kitamura M, Yuki M, Yoshizawa H, Nishizawa Y, Tomita Y
  • Organizer: 99th annual meeting of United States & Canadian Academy of Pathology
  • Place of Presentation: Washington D. C., U. S. A.
• [Presentation] 胆・膵領域の採取法別細胞所見と問題点 (2009)
  • Author(s): 竹中明美、冨田裕彦, 他
  • Organizer: 第50回日本臨床細胞学会春季大会
  • Place of Presentation: 京王プラザホテル(東京都)
  • Year and Date: 2009-06-29
• [Book] 解明 病理学 病気のメカニズムを解く 各論 第12章 乳腺 第16章 骨・軟部組織 (2009)
  • Author(s): 冨田裕彦
  • Total Pages: 827
  • Publisher: 医歯薬出版株式会社