Establishment of method to re-educate mecrophage differentiation towards dendritic cells on the view of regeneration medicine
Project/Area Number |
21590416
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Experimental pathology
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Research Institution | University of the Ryukyus |
Principal Investigator |
SAIO Masanao 琉球大学, 医学部附属病院, 准教授 (40242721)
|
Co-Investigator(Kenkyū-buntansha) |
TAKAMI Tsuyoshi 岐阜大学, 大学院・医学系研究科, 教授 (70136943)
YOSHIMI Naoki 琉球大学, 大学院・医学研究科, 教授 (30166996)
TOMITA Mariko 琉球大学, 大学院・医学研究科, 准教授 (80381250)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 腫瘍内マクロファージ / マウス / 樹状細胞 |
Research Abstract |
Granulocyte macrophage colony stimulating factor(GM-CSF) treatment alone could not alter expression level of macrophage differentiation. On the other hands, when the TIM was treated with GM-CSF and siRNA for macrophage colony stimulating factor(M-CSF) receptor(M-CSFR) altered the expression of signal pathway proteins towards dendritic cell like feature. Above findings indicated we successfully re-educated(re-differentiated) TIM towards monocyte-derived dendritic cells like population and we showed the macrophage plasticity.
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Report
(4 results)
Research Products
(2 results)
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[Journal Article] Combined GM-CSF treatment and M-CSF inhibition of tumor-associated macrophages induces dendritic cell-like signaling in vitro2011
Author(s)
Kitoh, Y., Saio, M., Gotoh, N., Umemura, N., Nonaka, K., Bai, J., Vizkeleti, L., Torocsik, D., Balazs, M., Adany, R., Takami, T.
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Journal Title
Int J Oncol
Volume: 38
Pages: 1409-1419
Related Report
Peer Reviewed