The search for DNA methylation-based biomarkers in cancer
| Project/Area Number |
21590425
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 腫瘍 / 遺伝子 / 発現制御 / 転写抑制 / メチルCpG結合蛋白 / エピジェネティクス / MeTA / マイクロアレイ / 遺伝子発現マイクロアレイ |
|---|
| Research Abstract |
We have developed a novel method called"microarray coupled with methyl-CpG targeted transcriptional activation" (MeTA-array for short), which is useful in identifying hypermethylation-mediated silenced genes in cancer. The majority of genes identified by this method had more stringent criteria of CpG islands at the promoter region at high frequency. We have applied MeTA-array to pancreatic cancer cells and identified several genes hypermethylated in primary pancreatic cancers in a tumor-specific manner. These genes should be useful as candidates for tumor-specific biomarkers.
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] DCK is frequently inactivated in acquired gemcitabine-resistant human cancer cells. Biochem. Biophys2012
Author(s)
Saiki Y, Yoshino Y, Fujimura H, Manabe T, Kudo Y, Shimada M, Mano N, Nakano T, Lee Y, Shimizu S, Oba S, Fujiwara S, Shimizu H, Chen N, Nezhad ZK, Jin G, Fukushige S, Sunamura M, Ishida M, Motoi F, Egawa S, Unno M, Horii A.
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Journal Title
Res. Commun
Volume: 421巻
Pages: 98-104
Related Report
Peer Reviewed
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[Presentation] S100A4 regulates tumor growth, motility, and invasion in pancreatic cancer2011
Author(s)
Sekine H, Tabata T, Tsukamoto N, Chen N, Sato K, Umetsu Y, Nakamura K, Kim G, Yamamura A, Yoshino Y, Fukushige S, Sunamura M, Horii A.
Organizer
60th Annual Meeting of the American Society of Human Genetics
Place of Presentation
Washington DC, USA
Year and Date
2011-01-03
Related Report
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[Presentation] S100A4 regulates tumor growth, motility, and invasion in pancreatic cancer2010
Author(s)
Sekine H, Tabata T, Tsukamoto N, Yamamura A, Abe K, Yoshino Y, Sato K, Chen N, Umetsu Y, Sato D, Gu Z, Fukushige S, Shima K, Motoi F, Egawa S, Sunamura M, Horii A.
Organizer
101st American Association for Cancer Research Annual Meeting
Place of Presentation
Washington DC, USA
Year and Date
2010-04-21
Related Report
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[Presentation] Expression of the N-myc downstream-regulated gene 2 (NDRG2)is frequently suppressed by promoter hypermethylation in human gastrointestinal and pancreatic cancers2010
Author(s)
Yamamura A, Miura K, Karasawa H, Abe K, Mizuguchi Y, Jin G, Gu Z, Fukushige S, Kaneko N, Kinouchi M, Ando T, Yazaki N, Tanaka N, Sase T, Shibata C, Sasaki I, Horii A.
Organizer
101st American Association for Cancer Research Annual Meeting
Place of Presentation
Washington DC, USA.
Year and Date
2010-04-21
Related Report
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