| Project/Area Number |
21590427
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Akita University |
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Principal Investigator |
OMORI Yasuhfumi 秋田大学, 大学院・医学系研究科, 准教授 (90323138)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIOKA Toshiaki 秋田大学, 医学部, 助教 (80302264)
KATSUHIKO Enomoto 秋田大学, 大学院・医学系研究科, 教授 (20151988)
NISHIKAWA Yuji 旭川医科大学, 医学部, 教授 (90208166)
YAMAMOTO Yohei 秋田大学, 大学院・医学系研究科, 助教 (70400512)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 腫瘍 / 肝細胞癌 / 癌幹細胞 / コネキシン / Tet-offシステム / side population / side poulation |
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| Research Abstract |
While connexin protein is localised in plasma membrane and functions tumour-suppressively, it often translocates into cytoplasm of cancer cells. In this study, discovering that cytoplasmic accumulation of connexin enhanced self-renewal of cancer stem cells, we successfully proved that an increased number of cancer stem cells elevated the incidence of cancer metastasis. It is strongly expected that cancer metastasis could be controlled by manipulating subcellular localisation of connexin.
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