| Project/Area Number |
21590429
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Yamagata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HAYASAKA Kiyoshi 山形大学, 医学部, 教授 (20142961)
NAKAJIMA Osamu 山形大学, 医学部, 教授 (80312841)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 糖尿病 / インスリン分泌不全 / 膵ベータ細胞 / MODY(若年発症成人型糖尿病) / 概日リズム / 生物時計 / アポトーシス / 膵β細胞 / インスリン分泌 / 膵島 / 視交叉上核 / 制限給餌 / リズム同調 / インスリン / クリプトクロム(CRY) / 耐糖能異常 / 給餌性概日リズム |
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| Research Abstract |
We previously showed that transgenic mice ubiquitously expressing mouse cryptochrome1 (CRY1) with a mutation in cysteine414 display not only anomalous circadian behavior but also symptoms of diabetes mellitus.
In order to clarify yet uncovered pathogenesis of the diabetes, in this study we examined age-dependent characteristics of the disorder of the transgenic mice, and found that the symptom resemble human MODY (maturity onset diabetes mellitus of the young). We showed that the mice showed from young age reduced expression of insulin gene along with several genes whose expression is involved in the function of ss-cells, which can cause early-onset diabetes similar to human MODY.
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