Breakdown of immunological tolerance by aberrant cell trafficking of B1 cells in a murine model for SLE

• Project/Area Number: 21590430
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: The University of Tokyo
• Principal Investigator: ISHIKAWA Sho 東京大学, 大学院・医学系研究科, 准教授 (00159691)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: SLE / ケモカイン / B1細胞 / 免疫寛容 / 濾胞性ヘルパーT細胞

Research Abstract

Neutralizing anti-BLC/CXCL13 monoclonal antibody effectively inhibited B1 cell migration in chemotaxis assay and administration of the antibody resulted in increased number of peripheral B1 cells in aged BWF1 mice. Therapeutic injections of the antibody to pre-lupus BWF1 mice significantly prolonged their survival compared to those by control IgG. The levels of TFH and IgG anti-DNA antibody remained unchanged in treated mice whereas IL-17 level in the serum was markedly reduced by the antibody injection. These results suggest that BLC/CXCL13 is a possible target for immunotherapy of SLE.

Research Products

• [Journal Article] Children's immunology, what can we learn from animal studies(3): Impaired mucosal immunity in the gut by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin(TCDD): A possible role for allergic sensitization (2009)
  • Author(s): Ishikawa S
  • Journal Title: J. Toxicol. Sci Volume: 34
  • URL: http://www.jtoxsci.org
  • Peer Reviewed
• [Journal Article] Children's immunology, what can we learn from animal studies(3) : Impaired mucosal immunity in the gut by 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD) : A possible role for allergic sensitization. (2009)
  • Author(s): 石川昌
  • Journal Title: J.Toxicol.Sci. 34 Pages: 349-361
  • Peer Reviewed
• [Journal Article] ダイオキシンによる腸管粘膜免疫の破綻とアレルギー感作 (2009)
  • Author(s): 石川昌
  • Journal Title: 東京大学「環境安全」 123 Pages: 3-5
• [Presentation] ダイオキシンによる腸管免疫の破綻とアレルギー感作 (2009)
  • Author(s): 石川昌
  • Organizer: 第16回免疫毒性学会シンポジウム「子どもと免疫」
  • Place of Presentation: 旭川市民文化会館、旭川,北海道
  • Year and Date: 2009-08-27
• [Presentation] ダイオキシンによる腸管免疫の破綻とアレルギー (2009)
  • Author(s): 石川昌
  • Organizer: 第16回日本免疫毒性学会
  • Place of Presentation: 北海道旭川市民文化会館
  • Year and Date: 2009-08-27
• [Book] ケモカイン. New薬理学改訂第6版 (2012)
  • Author(s): 石川昌、松島綱治
  • Publisher: 南江堂
• [Book] 分子環境医学 (2010)
  • Author(s): 分子予防環境医学研究会
  • Total Pages: 850
  • Publisher: 本の泉社