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Sharing pathogenic mechanism between non-alcoholic steatohepatitis and primary biliary cirrhosis

Research Project

Project/Area Number 21590433
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Experimental pathology
Research InstitutionUniversity of Toyama

Principal Investigator

TSUNEYAMA Koichi  富山大学, 大学院・医学薬学研究部(医学), 准教授 (10293341)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords疾患モデル動物 / NASH, PBC,酸化ストレス / NASH / PBC / 酸化ストレス
Research Abstract

Pathological characteristics of non-alcoholic steatohepatitis(NASH) and primary biliary cirrhosis(PBC) were examined. Obese female NASH patients of the older age have a tendency to show PBC-mimicking biliary damages, portal inflammation as well as autoantibodies. Similar pathological changes were observed in older aged female NASH mice model. In contrast, NASH features were not observed in any PBC model mice. In visceral fat of NASH mice model, TNF-αor IL6-positive macrophages aggregation was detected. In drug-induced liver injury mice model, estrogen pretreatment reduced inflammatory severity, while progesterone pretreatment enhanced it. We hypothesized that effects of inflammatory cytokines in the obesity women were enhanced by hormonal imbalance, and easy to cause biliary damages and portal inflammation.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (84 results)

All 2012 2011 2010 2009

All Journal Article (58 results) (of which Peer Reviewed: 58 results) Presentation (26 results)

  • [Journal Article] The role of natural killer(NK) and NK T cells in the loss of tolerance in murine PBC2012

    • Author(s)
      Shimoda S, Tsuneyama K, et al.
    • Journal Title

      Clin Exp Immunol

      Volume: 168(3) Pages: 279-284

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Spirulina improves non-alcoholic steatohepatitis, visceral fat macrophage aggregation, and serum leptin in a mouse model of metabolic syndrome2012

    • Author(s)
      Fujimoto M, Tsuneyama K, et al.
    • Journal Title

      Dig Liver Dis

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mechanism of exacerbative effect of progesterone on drug-induced liver injury2012

    • Author(s)
      Toyoda Y, Endo S, Tsuneyama K, et al.
    • Journal Title

      Toxicol Sci

      Volume: 126(1) Pages: 16-27

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparative analysis of portal cell infiltrates in AMAy-positive versus AMA-negative PBC2012

    • Author(s)
      Jin Q, Moritoki Y, Lleo A, Tsuneyama K, et al.
    • Journal Title

      Hepatology

      Volume: 55(5) Pages: 1495-506

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pathological features of new animal models for primary biliary cirrhosis2012

    • Author(s)
      Tsuneyama K, et al.
    • Journal Title

      Int J Hepatol

      Volume: 2012 Pages: 403954-403954

    • NAID

      120004186279

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pathological features of new animal models for primary biliary cirrhosis2012

    • Author(s)
      Tsuneyama K.
    • Journal Title

      Int J Hepatol

      Volume: 2012 Pages: 1-7

    • DOI

      10.1155/2012/403954

    • NAID

      120004186279

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Plasma cells and the chronic nonsuppurative destructive cholangitis of primary biliary cirrhosis2012

    • Author(s)
      Takahashi T.
    • Journal Title

      Hepatology

      Volume: 55(3) Issue: 3 Pages: 846-855

    • DOI

      10.1002/hep.24757

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum soluble MD-1 levels increase with disease progression in autoimmune prone MRL(lpr/lpr) mice2012

    • Author(s)
      Sasaki S.
    • Journal Title

      Mol Immunol

      Volume: 49(4) Issue: 4 Pages: 611-620

    • DOI

      10.1016/j.molimm.2011.10.008

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of innate IL-5-producing cells and their role in lung eosinophil regulation and antitumor immunity2012

    • Author(s)
      Ikutani M.
    • Journal Title

      J Immunol

      Volume: 188(2) Issue: 2 Pages: 703-713

    • DOI

      10.4049/jimmunol.1101270

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of immune-related factors in diclofenac-induced acute liver injury in mice2012

    • Author(s)
      Yano A.
    • Journal Title

      Toxicology

      Volume: 293(1-3) Issue: 1-3 Pages: 107-114

    • DOI

      10.1016/j.tox.2012.01.008

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cattle bile but not bear bile or pig bile induces lipid profile changes and fatty liver injury in mice: mediation by cholic acid2012

    • Author(s)
      Watanabe S.
    • Journal Title

      The Journal of Toxicological Sciences

      Volume: 37 Issue: 1 Pages: 105-121

    • DOI

      10.2131/jts.37.105

    • NAID

      10030037499

    • ISSN
      0388-1350, 1880-3989
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Advantages and disadvantages of hyperbaric oxygen treatment in mice with obesity hyperlipidemia and steatohepatitis2011

    • Author(s)
      Tsuneyama K, et al.
    • Journal Title

      ScientificWorldJournal

      Volume: 11 Pages: 2124-35

    • NAID

      120005464896

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Estradiol and progesterone modulate halothane-induced liver injury in mice2011

    • Author(s)
      Toyoda Y, Miyashita T, Endo S, Tsuneyama K, et al.
    • Journal Title

      Toxicol Lett

      Volume: 204(1) Pages: 17-24

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Innate immunity and primary biliary cirrhosis : activated invariantnatural killer T cells exacerbate murine autoimmune cholangitis and fibrosis2011

    • Author(s)
      Wu SJ, Yang YH, Tsuneyama K, et al.
    • Journal Title

      Hepatology

      Volume: 53(3) Pages: 915-25

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] B cells promote hepatic inflammation, biliary cyst formation, and salivary gland inflammation in the NOD. c3c4 model of autoimmune cholangitis2011

    • Author(s)
      Moritoki Y, Tsuda M, Tsuneyama K, et al.
    • Journal Title

      Cell Immunol

      Volume: 268(1) Pages: 16-23

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] B cell depletion therapy exacerbates murine PBC2011

    • Author(s)
      Dhirapong A, Lleo A, Yang GX, Tsuneyama K, et al.
    • Journal Title

      Hepatology

      Volume: 53(2) Pages: 527-35

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interaction between Toll-like receptors and natural killer cells in the destruction of bile ducts in primary biliary cirrhosis2011

    • Author(s)
      Shimoda S.
    • Journal Title

      Hepatology

      Volume: 53(4) Issue: 4 Pages: 1270-1281

    • DOI

      10.1002/hep.24194

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Telmisartan improves insulin resistance and modulates adipose tissue macrophage polarization in high-fat-fed mice2011

    • Author(s)
      Fujisaka S.
    • Journal Title

      Endocrinology

      Volume: 152(5) Issue: 5 Pages: 1789-1799

    • DOI

      10.1210/en.2010-1312

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of bezafibrate in nonalcoholic steatohepatitis model mice with monosodium glutamate-induced metabolic syndrome2011

    • Author(s)
      Sasaki Y.
    • Journal Title

      Eur J Pharmacol

      Volume: 662(1-3) Issue: 1-3 Pages: 1-8

    • DOI

      10.1016/j.ejphar.2011.04.051

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fine phenotypic and functional characterization of effector cluster of differentiation 8 positive T cells in human patients with primary biliary cirrhosis2011

    • Author(s)
      Tsuda M.
    • Journal Title

      Hepatology

      Volume: 54(4) Issue: 4 Pages: 1293-1302

    • DOI

      10.1002/hep.24526

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The multi-hit hypothesis of primary biliary cirrhosis : polyinosinic-polycytidylic acid (poly I:C) and murine autoimmune cholangitis2011

    • Author(s)
      Ambrosini YM.
    • Journal Title

      Clin Exp Immunol

      Volume: 166(1) Issue: 1 Pages: 110-120

    • DOI

      10.1111/j.1365-2249.2011.04453.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Advantages and disadvantages of hyperbaric oxygen treatment in mice with obesity hyperlipidemia and steatohepatitis2011

    • Author(s)
      Tsuneyama K.
    • Journal Title

      ScientificWorldJournal

      Volume: 11 Pages: 2124-2135

    • DOI

      10.1100/2011/380236

    • NAID

      120005464896

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-4 mediates dicloxacillin-induced liver injury in mice.2011

    • Author(s)
      Higuchi S, Kobayashi M, Yoshikawa Y, Tsuneyama K, et al.
    • Journal Title

      Toxicol Lett.

      Volume: 200(3) Pages: 139-145

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Septic shock is associated with receptor for advanced glycation end products ligation of LPS.2011

    • Author(s)
      Yamamoto Y, Harashima A, Saito H, Tsuneyama K, et al.
    • Journal Title

      J Immunol.

      Volume: 186(5) Pages: 3248-3257

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] B cells promote hepatic inflammation, biliary cyst formation, and salivary gland inflammation in the NOD.c3c4 model of autoimmune cholangitis.2011

    • Author(s)
      Moritoki Y, Tsuda M, Tsuneyama K, et al.
    • Journal Title

      Cell Immunol.

      Volume: 268(1) Pages: 16-23

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Innate immunity and primary biliary cirrhosis : Activated invariant natural killer T cells exacerbate murine autoimmune cholangitiS and fibrosis2011

    • Author(s)
      Wu SJ, Yang YH, Tsuneyama K, et al.
    • Journal Title

      Hepatology.

      Volume: 53(3) Pages: 915-925

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deletion of interleukin-6 in mice with the dominant negative form of transforming growth factor beta receptor II improves colitis but exacerbates autoimmune cholangitis2010

    • Author(s)
      Zhang W, Tsuda M, Yang GX, Tsuneyama K, et al.
    • Journal Title

      Hepatology

      Volume: 52(1) Pages: 215-22

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The traditional Japanese formula keishibukuryogan reduces liver injury and inflammation in patients with nonalcoholic fatty liver disease2010

    • Author(s)
      Fujimoto M, Tsuneyama K, et al.
    • Journal Title

      Ann. N Y. Acad Sci

      Volume: 1190 Pages: 151-8

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nutrition, geoepidemiology, and autoimmunity2010

    • Author(s)
      Selmi C, Tsuneyama K.
    • Journal Title

      Autoimmun Rev

      Volume: 9(5)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Deletion of interleukin-6 in mice with the dominant negative form of transforming growth factor beta receptor II improves colitis but exacerbates autoimmune cholangitis.2010

    • Author(s)
      Zhang W, Tsuda M, Yang GX, T suneyama K, et al.
    • Journal Title

      Hepatology

      Volume: 52(1) Pages: 215-222

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-17 is involved in alpha-naphthylisothiocyanate-induced liver injury in mice.2010

    • Author(s)
      Kobayashi M, Higuchi S, Mizuno K, Tsuneyama K, et al.
    • Journal Title

      Toxicology.

      Volume: 10,275(1-3): Pages: 50-57

    • NAID

      130007003175

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Kangen-karyu improves memory deficit caused by aging through normalization of neuro-plasticity-related signaling system and VEGF system in the brain.2010

    • Author(s)
      Zhao Q, Yokozawa T, Yamabe N, Tsuneyama K, et al.
    • Journal Title

      J Ethnopharmacol.

      Volume: 15;131(2) Pages: 377-385

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endometrioid adenocarcinoma of the vagina with a microglandular pattern arising from endometriosis after hysterectomy.2010

    • Author(s)
      Nomoto K, Hori T, Kiya C, Fukuoka J, Nakashima A, Hidaka T, Saito S, Mikami Y, Tsuneyama K, Takano Y.
    • Journal Title

      Pathol Int.

      Volume: 60(9) Pages: 636-641

    • NAID

      10031123389

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of an ultrasound-emitting device for performing rapid immunostaining procedures.2010

    • Author(s)
      Hatta H, Tsuneyama K, Kondo T, Takano Y.
    • Journal Title

      J Histochem Cytochem.

      Volume: 58(5) Pages: 421-428

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autoimmune Liver injury and Non-alcoholic fatty liver disease.2010

    • Author(s)
      Li J, Wang J, Tsuneyama K, Liu Y.
    • Journal Title

      Chinese J.Gastroenterol.

      Volume: 15(9) Pages: 525-527

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] B cell depletion therapy exacerbates murine primary biliary cirrhosis.2010

    • Author(s)
      Dhirapong A, Lleo A, Yang GX, Tsuneyama K, et al.
    • Journal Title

      Hepatology.

      Volume: 53(2) Pages: 527-535

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Application of a new histological staging and grading system for primary biliary cirrhosis to liver biopsy specimens : Interobserver agreement.2010

    • Author(s)
      Nakanuma Y, Zen Y, Harada K, Sasaki M, Nonomura A, Uehara T, Sano K, Kondo F, Fukusato T, Tsuneyama K, et al
    • Journal Title

      Pathol Int. 60(3)

      Pages: 167-174

    • NAID

      10029330966

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The traditional Japanese formula keishibukuryogan reduces liver injury and inflammation in patients with nonalcoholic fatty liver disease.2010

    • Author(s)
      Fujimoto M, Tsuneyama K, et al.
    • Journal Title

      Ann N Y Acad Sci. 1190(1)

      Pages: 151-158

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Usefulness of Positron Emission Tomography for management of ocular sebaceous carcinoma.2010

    • Author(s)
      Yasumura S, Shojaku H, Wada R, Watanabe Y, Shojaku H, Seto H, Kawano M, Tsuneyama K.
    • Journal Title

      Clin Nucl Med. 35(2)

      Pages: 98-100

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Treatment of hepatocellular carcinoma with adeno-associated virus encoding interleukin-15 superagonist.2010

    • Author(s)
      Chang CM, Lo CH, Shih YM, Chen Y, Wu PY, Tsuneyama K, et al
    • Journal Title

      Hum Gene Ther. 21(5)

      Pages: 611-621

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of candidate genes involved in endogenous protection mechanisms against acute pancreatitis in mice.2010

    • Author(s)
      Nakada S, Tsuneyama K, et al.
    • Journal Title

      Biochem Biophys Res Commun. 391(3)

      Pages: 1342-1347

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Olive leaf extract prevents spontaneous occurrence of non-alcoholic steat ohepatitis in SHR/NDmcr-cp rats.2010

    • Author(s)
      Omagari K, Kato S, Tsuneyama K, et al.
    • Journal Title

      Pathology. 42(1)

      Pages: 66-72

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nutrition, geoepidemiology, and autoimmunity.2010

    • Author(s)
      Selmi C, Tsuneyama K.
    • Journal Title

      Autoimmun Rev. 9(5)

      Pages: 267-270

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] B-cell depletion with anti-CD20 ameliorates autoimmune cholangitis but exacerbates colitis in transforming growth factor-beta receptor II dominant negative mice2009

    • Author(s)
      Moritoki Y, Lian ZX, Lindor K, Tuscano J, Tsuneyama K, et al.
    • Journal Title

      Hepatology

      Volume: 50(6) Pages: 1893-903

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Deletion of interleukin-12p40 suppresses autoimmune cholangitis in dominant negative transforming growth factor beta receptor type II mice2009

    • Author(s)
      Yoshida K, Yang GX, Zhang W, Tsuda M, Tsuneyama K, et al.
    • Journal Title

      Hepatology

      Volume: 50(5) Pages: 1494-500

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Beta-glucosylceramide ameliorates liver inflammation in murine autoimmune cholangitis2009

    • Author(s)
      Zhang W, Moritoki Y, Tsuneyama K, et al.
    • Journal Title

      Clin Exp Immunol

      Volume: 157(3) Pages: 359-64

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Treatment of hepatocellular carcinoma with adeno-associated virus encoding interleukin-15 superagonist.2009

    • Author(s)
      Chang CM, Lo CH, Shih YM, Chen Y, Wu PY, Tsuneyama K, et al.
    • Journal Title

      Hum Gene Ther.

      Volume: 21(5) Pages: 611-621

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A role for IL-17 in induction of an inflammation at the fetomaternal interface in preterm labour.2009

    • Author(s)
      Ito M, Nakashima A, Hidaka T, Okabe M, Bac ND, Ina S, Yoneda S, Shiozaki A, Sumi S, Tsuneyama K, et al.
    • Journal Title

      J Reprod Immunol. 84(1)

      Pages: 75-85

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of CX3CL1/fractalkine in osteoclast differentiation and bone resorption.2009

    • Author(s)
      Koizumi K, Saitoh Y, Minami T, Takeno N, Tsuneyama K, et al.
    • Journal Title

      J Immunol. 183(12)

      Pages: 7825-7831

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CX3CL1 (fractalkine) : a signpost for biliary in flammation in primary biliary cirrhosis.2009

    • Author(s)
      Shimoda S, Harada K, Niiro H, Taketomi A, Maehara Y, Tsuneyama K, et al.
    • Journal Title

      Hepatology. 51(2)

      Pages: 567-575

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] B-cell depletion with anti-CD20 ameliorates autimmune cholangitis but exacerbates colitis in transforming growth factor-beta receptor II dominant negative mice.2009

    • Author(s)
      Moritoki Y, Lian' ZX, Lindor K, Tuscano J, Tsuneyama K, et al.
    • Journal Title

      Hepatology. 50(6)

      Pages: 1893-1903

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Peribiliary cyst of common bile duct : possible cause of refractory jaundice.2009

    • Author(s)
      Takahashi H, Miwa S, Nomoto K, Hayashi S, Tsuneyama K, Takano Y.
    • Journal Title

      Pathol Int. 59(9)

      Pages: 692-693

    • NAID

      10027381753

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulatory mechanisms for adipose tissue M1 and M2 macrophges in diet-induced obese mice.2009

    • Author(s)
      Fujisaka S, Usui I, Bukhari A, Ikutani M, Oya T, Kanatani Y, Tsuneyama K, et al.
    • Journal Title

      Diabetes 58(11)

      Pages: 2574-2582

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dose dependent development of diabetes mellitus and non-alcoholic stea tohepatitis in monosodium glutamate-induced obese mice.2009

    • Author(s)
      Sasaki Y, Suzuki W, Shimada T, Iizuka S, Nakamura S, Nagata M, Fujimoto M, Tsuneyama K, et al.
    • Journal Title

      Life Sci. 85(13-14)

      Pages: 490-498

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Beta-glucosylceramide ameliorates liver inflammation in murine autoim munecholangitis.2009

    • Author(s)
      Zhang W, Moritoki Y, Tsuneyama K, et al.
    • Journal Title

      Clin Exp Immunol. 157(3)

      Pages: 359-364

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Knockdown of superoxide dismutase 2 enhances acetaminophen-induced hepatotoxicity in rat.2009

    • Author(s)
      Yoshikawa Y, Morita M, Hosomi H, Tsuneyama K, et al.
    • Journal Title

      Toxicology. 264(1-2)

      Pages: 89-95

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Drug-induced hepatotoxicity test using gamma-glutamylcysteine synthetase knockdown rat.2009

    • Author(s)
      Morita M, Akai S, Hosomi H, Tsuneyama K, et al.
    • Journal Title

      Toxicol Lett. 189(2)

      Pages: 159-165

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of liver-infiltrating CD3+CD56+ natural killer T cells in the patho genesis of nonalcoholic fatty liver disease.2009

    • Author(s)
      Tajiri K, Shimizu Y, Tsuneyama K, et al.
    • Journal Title

      Eur J Gastroenterol Hepatol. 21(6)

      Pages: 673-680

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Pathological characteristics of the Iidney and bone of patients with itai-itai disease (chronic cadmium toxicity)2012

    • Author(s)
      Tsuneyama K.
    • Organizer
      101^<st> annual meeting, United States and Canadian Academy of Pathology
    • Place of Presentation
      Vancouver (Canada)
    • Year and Date
      2012-03-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] 深層水の医療分野への応用について2011

    • Author(s)
      常山幸一
    • Organizer
      環日本海機能水バイオ研究会
    • Place of Presentation
      富山(招待講演)
    • Year and Date
      2011-11-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] 肝疾患モデル動物2011

    • Author(s)
      常山幸一
    • Organizer
      第4回ATBF1研究会
    • Place of Presentation
      名古屋(招待講演)
    • Year and Date
      2011-11-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] 自然発症肥満・糖尿病・NASHモデル(TSOD)マウス脾臓における異常鉄沈着の病理組織学的検討2011

    • Author(s)
      常山幸一, 他
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] TSODマウスにおける異常鉄沈着の病理組織学的検討2010

    • Author(s)
      常山幸一、西田健志、藤本誠
    • Organizer
      第6回TSODマウス研究会情報交換会
    • Place of Presentation
      東京
    • Year and Date
      2010-11-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] Evidence-based efficacy of Chinese herbal medicine and functional foods in animal models of metabolic syndrome associated liver diseases2010

    • Author(s)
      Tsuneyama K
    • Organizer
      The 5th Symposium of TCM Pharmaceutics of WFCMS(招待講演)
    • Place of Presentation
      Suzhou, China
    • Year and Date
      2010-10-23
    • Related Report
      2011 Final Research Report
  • [Presentation] Evidence-based efficacy of Chinese herbal medicine and functional foods in animal models of metabolic syndrome associated liver diseases.2010

    • Author(s)
      Koichi Tsuneyama
    • Organizer
      The 5th Symposium of TCM Pharmaceutics of WFCMS
    • Place of Presentation
      Suzhou, China
    • Year and Date
      2010-10-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] Autoimmune biliary damages and NASH2010

    • Author(s)
      Tsuneyama K
    • Organizer
      2010 Immune-Mediated Digestive Diseases Forum(招待講演)
    • Place of Presentation
      Beijing, China
    • Year and Date
      2010-06-12
    • Related Report
      2011 Final Research Report
  • [Presentation] Autoimmune biliary damages and NASH.2010

    • Author(s)
      Koichi Tsuneyama
    • Organizer
      2010 Immune-Mediated Digestive Diseases Forum
    • Place of Presentation
      Bejing, China
    • Year and Date
      2010-06-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] 自然発症肥満・糖尿病モデル(TSOD)マウスに発症ずるNASH肝腫瘍の経時的変化:病理学的解析2010

    • Author(s)
      常山幸一、藤本誠
    • Organizer
      第46回日本肝臓学会総会
    • Place of Presentation
      山形
    • Year and Date
      2010-05-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] メタボリック症候群関連肝疾患モデル動物を用いた和漢薬・機能性食品の効果解析と臨床への展開2010

    • Author(s)
      常山幸一
    • Organizer
      フォーラム富山「創薬」第31回研究会
    • Place of Presentation
      富山
    • Year and Date
      2010-05-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] 自然発症肥満・糖尿病モデル(TSOD)マウスに発症するNASH様肝病変の発症機序の解明2010

    • Author(s)
      常山幸一, 他
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      東京
    • Year and Date
      2010-04-29
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Pathological characterization of new animal models of Primary Biliary Cirrhosis2010

    • Author(s)
      Tsuneyama K.
    • Organizer
      2010 International Seminar on Digestive Diseases
    • Place of Presentation
      北京(中国)
    • Year and Date
      2010-03-26
    • Related Report
      2011 Final Research Report
  • [Presentation] Pathological characterization of new animal models of Primary Biliary Cirrhosis2010

    • Author(s)
      Koichi Tsuneyama
    • Organizer
      2010 International Seminar on Digestive Diseases
    • Place of Presentation
      北京大学人民医院
    • Year and Date
      2010-03-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] TSOD mouse : a new spontaneous model of nonalcoholic steatohepatitis and hepatocellular carcinoma associated with obesity, type 2 diabetes, and hyperlipidemia2010

    • Author(s)
      Tsuneyama K, et al.
    • Organizer
      第20回アジア太平洋肝臓会議
    • Place of Presentation
      北京(中国)
    • Year and Date
      2010-03-25
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] Spirulina and its constituent phycocyanin improve visceral fat macrophage aggregation, serum adiponectin level, and stea tohepatitis in a mouse model of NAFLD associated with metabolic syndrome2010

    • Author(s)
      Koichi Tsuneyama
    • Organizer
      第20回アジア太平洋肝臓会議
    • Place of Presentation
      北京(中国)
    • Year and Date
      2010-03-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] New animal models for Non-alcoholic steatohepatitis(NASH) based on metabolic syndrome2009

    • Author(s)
      Tsuneyama K
    • Organizer
      中国消化器病学会(招待講演)
    • Place of Presentation
      広州(中国)
    • Year and Date
      2009-12-05
    • Related Report
      2011 Final Research Report
  • [Presentation] New animal models for Non-alcoholic steatohepatitis (NASH) based on metabolic syndrome2009

    • Author(s)
      Koichi Tsuneyama
    • Organizer
      中国消化器病学会
    • Place of Presentation
      広州(中国)
    • Year and Date
      2009-12-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] 自然発症NASH(非アルコール性脂肪性肝炎)-HCC(肝細胞癌)モデルマウスとしてのTSODマウスの有用性2009

    • Author(s)
      常山幸一
    • Organizer
      第5回TSOD(肥満・糖尿病)マウス研究会情報交換会
    • Place of Presentation
      東京
    • Year and Date
      2009-11-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] 富山湾海洋深層水か調整した等張液による創傷治癒促進効果 in vitro study2009

    • Author(s)
      常山幸一
    • Organizer
      第11回日本褥瘡学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2009-09-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] New Animal model of Non-alcoholic Fatty Liver Disease (NAFLD) based on Metabolic Syndrome : MSG mice & TSOD mice.2009

    • Author(s)
      Koichi Tsuneyama
    • Organizer
      Changchun international digestive disease and liver disease peak forum
    • Place of Presentation
      長春(中国)
    • Year and Date
      2009-08-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] メタボリック症候群関連脂肪性肝炎モデルマウス(MSGマウス)を用いたカロリー制限の効果2009

    • Author(s)
      常山幸一
    • Organizer
      第45回日本肝臓学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2009-06-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] New Animal model of Non-alcoholic Fatty Liver Disease(NAFLD) based on Metabolic Syndrome : MSG mice & TSOD mice2009

    • Author(s)
      Tsuneyama K
    • Organizer
      Changchun international digestive disease and liver disease peak forum(招待講演)
    • Place of Presentation
      長春(中国)
    • Year and Date
      2009-05-02
    • Related Report
      2011 Final Research Report
  • [Presentation] 自然発症肥満・糖尿病モデル(TSOD)マウスの肝病NAFLD/NASHモデルとしての有用性2009

    • Author(s)
      常山幸一, 他
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      京都
    • Year and Date
      2009-05-02
    • Related Report
      2011 Final Research Report
  • [Presentation] メタボリック症候群関連脂肪性肝炎モデルマウス(MSGマウス)におけるスピルリナの疾患予防効果2009

    • Author(s)
      常山幸一
    • Organizer
      第63回日本栄養食糧学会
    • Place of Presentation
      長崎
    • Year and Date
      2009-05-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] 自然発症肥満・糖尿病モデル(TSOD)マウスの肝病変NAFLD/NASHモデルとしての有用性2009

    • Author(s)
      常山幸一
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      京都
    • Year and Date
      2009-05-02
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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