| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
Ret tyrosine kinasse is a member of“dependence receptor"which induces apoptosis in the absence of its ligands. Ret is cleaved at D707 and D1017 by caspase, and intracellular fragment between D707 and D1017 can induce cell death. To determine the importance of Ret proapoptotic activity in vivo, we generated Ret D707N mutant mice. D707N Homozygote showed hyperplasia of neural cells in enteric, sympathetic and parapympathetic neural systems. In addition, adenopituitary lobe in pituitary gland was hyperplastic in D707N mice. To study the molecular mechanism of Ret proapoptotic activity, we examined the biological function of Ret fragment. Interestingly, Ret fragment is localized in the cell nucleus, and Ret fragment shows suppressive transcriptional activity.
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