Elucidation of mechanisms underlying production of myeloid derived suppressor cells and possible involvement of interleukin-17 in the process.

• Project/Area Number: 21590443
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: INABA Tohru (2010-2011) 京都府立医科大学, 医学研究科, 講師 (60203204); 今西 二郎 (2009) Kyoto Prefectural University of Medicine, 医学研究科, 教授 (40112510)
• Co-Investigator(Kenkyū-buntansha): KITA Masakazu 京都府立医科大学, 医学研究科, 準教授 (60153087) ; HIRAI Hirai 京都大学, 医学研究科, 助教 (50315933) ; 稲葉 亨 京都府医科大学, 医学研究科, 講師 (60203204)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 骨髄球系抑制細胞 / インターロイキン17 / 造血 / 腫瘍 / 免疫 / 癌 / 骨髄由来抑制細胞 / 骨髄球系細胞 / 癌転移

Research Abstract

The developmental process of Myeloid derived suppressor cells(MDSCs) remains unknown. In IL-17A or IL-17F knockout mice, MDSCs were induced at similar frequency as wild type mice. Taking into account the previous report showing that IL-17 receptor signaling is necessary for MDSCs induction, these results suggest that IL-17A and IL-17F are functionally redundant in MDSCs induction.

Research Products

• [Journal Article] Galection-9 ameliorates acute Graft-versus-host disease through the induction of T-cell apoptosis (2011)
  • Author(s): Sakai K, Kawata E, Ashihara E, Nakagawa Y, Yamauchi A, Yao Y, Nagao R, Tanaka R, Yokota A, Takeuchi T, Hirai H, Kimura S, Hirashima M, Yoshimura N, Maekawa T
  • Journal Title: Eur J Immunol Volume: 41 Pages: 67-75
• [Journal Article] Growth inhibition of imatinib-resistant CML cells with the T315I mutation and hypoxia-adaptation by AV65-a novel Wnt/β-catenin signaling inhibitor (2011)
  • Author(s): Nagao R, Ashihara E, Kimura S, Strovel JW, Yao H, Takeuchi M, Tanaka R, Hayashi Y, Hirai H, Padia J, Strand K, Maekawa T
  • Journal Title: Cancer Lett Volume: 312(1) Pages: 91-100
  • NAID: 120003437105
• [Journal Article] Growth inhibition of imatinib-resistant CML cells with the T315 mutation and hypoxia-adaptation by AV65 。Va novel Wnt/υ-catenin signaling inhibitor (2011)
  • Author(s): Nagao, R., Ashihara, E., Kimura, S., Strovel, J. W., Yao, H., Takeuchi, M., Tanaka, R., Hayashi, Y., Hirai, H., Padia, J., Strand, K.
  • Journal Title: Cancer Letter Volume: 312(1) Issue: 1 Pages: 91-100
  • DOI: 10.1016/j.canlet.2011.08.002
  • Peer Reviewed
• [Journal Article] Galection-9 ameliorates acute Graft-versus-host disease through the induction of T-cell apoptosis (2011)
  • Author(s): Sakai K, Ashihara E, Maekawa T, et al
  • Journal Title: Eur J Immunol Volume: 41 Issue: 1 Pages: 67-75
  • DOI: 10.1002/eji.200939931
  • Peer Reviewed
• [Journal Article] Use of bicistronic vectors in combination with flow cytometry to screen for effective small interfering RNA target sequences (2010)
  • Author(s): Kamio N, Hirai H, Ashihara E, Tenen DG, Maekawa T, Imanishi J
  • Journal Title: Biochem Biophys Res Commun Volume: 393 Pages: 498-503
  • NAID: 120002426875
• [Presentation] BCR/ABL-Mediated Myeloid Expansion Is Promoted by C/EBP β, a Regulator of Emergency Granulopoiesis (2011)
  • Author(s): Hayashi, et al
  • Organizer: 53rd ASH Annual Meeting and Exposition
  • Place of Presentation: San Diego, USA
  • Year and Date: 2011-12-12
• [Presentation] BCR/ABL-Mediated Myeloid Expansion Is Promoted by C/EBPβ, a Regulator of Emergency Granulopoiesis (2011)
  • Author(s): Hayashi Y, Hirai H, Yao H, Yoshioka S, Satake S, Kamio N, Miura Y, Ashihara E, Fujiyama Y, Tenen DG, Maekawa T
  • Organizer: 53rd ASH Annual Meeting and Exposition
  • Place of Presentation: San Diego, US
• [Presentation] The developmental process of myeloid-derived suppressor cells in the bone marrow of tumor-bearing mice (2010)
  • Author(s): Nagao R, Hirai H, Satake S, Yao H, Tanaka R, Hayashi Y, Ashihara E, Maekawa T
  • Organizer: Kyoto University Global COE "Center for Frontier Medicine" International Symposium/Retreat 2010
  • Place of Presentation: Hyogo, Japan
  • Year and Date: 2010-11-05
• [Presentation] A flow cytometry-based method for screening of effective small interfering RNA target sequences (2010)
  • Author(s): Kamio N, Hirai H, Satake S, Tanaka R, Nagao R, Yao H, Hayashi Y, Takeuchi M, Ashihara E, Maekawa T
  • Organizer: 第16回日本遺伝子治療学会年次学術集会
  • Place of Presentation: 栃木
  • Year and Date: 2010-07-02
• [Remarks] 京都大学医学部附属病院輸血細胞治療部
  • URL: http://dtm.kuhp.kyoto-u.ac.jp/
• [Remarks] 京都大学医学部附属病院輸血細胞治療部
  • URL: http://dtm.kuhp.kyoto-u.ac.jp/
• [Remarks]
  • URL: http://www.kuhp.kyoto-u.ac.jp/~dtm/
• [Remarks]
  • URL: http://www.kpu-m.ac.jp/k/microbiol/mb/hp.htm