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Bone-metastatic tumor cells induce systemic immunosuppression through increase of immunoregulatory mesenchymal stem cells

Research Project

Project/Area Number 21590445
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Experimental pathology
Research InstitutionKeio University

Principal Investigator

KUDO Chie  慶應義塾大学, 医学部, 講師 (90424126)

Co-Investigator(Kenkyū-buntansha) KAWAKAMI Yutaka  慶應義塾大学, 医学部, 教授 (50161287)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywordsがん / 骨転移 / 免疫抑制 / 上皮間葉転換 / Snail / 骨髄
Research Abstract

Bone metastasis is frequently caused in cancer patients, and negatively affect their quality of life. However, there are no treatments to inhibit cancer metastasis toward bone itself. We found that Snail^+cancer cells preferentially metastasize into bone marrow than other organs, and produce systemic immunosuppression mediating via expansion of various immunoregulatory cells. We identified the Snail-downstream molecules that induce cancer metastasis and increase mesenchymal stem cells. These molecules would be good targets for cancer therapy to efficiently inhibit bone metastasis of cancer cells by breaking a crucial link to immunosuppression.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (41 results)

All 2012 2011 2010 2009 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (31 results) Remarks (1 results) Patent(Industrial Property Rights) (7 results) (of which Overseas: 6 results)

  • [Journal Article] The mechanisms of cancer immunoescape and development of overcoming strategies2011

    • Author(s)
      Yaguchi T, Kudo-Saito C, Yutaka Kawakami, et al.
    • Journal Title

      International Journal of Hematology

      Volume: 93 Pages: 294-3000

    • NAID

      10029533724

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The mechanisms of cancer immunoescape and development of overcoming strategies2011

    • Author(s)
      Yaguchi T, et al
    • Journal Title

      Int J Hematol

      Volume: 93(3) Issue: 3 Pages: 294-300

    • DOI

      10.1007/s12185-011-0799-6

    • Related Report
      2011 Annual Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 癌細胞による巧妙な免疫回避機構2012

    • Author(s)
      工藤千恵
    • Organizer
      日本耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      滋賀
    • Year and Date
      2012-02-16
    • Related Report
      2011 Final Research Report
  • [Presentation] 癌細胞による巧妙な免疫回避機構2012

    • Author(s)
      工藤千恵
    • Organizer
      日本耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      滋賀(琵琶湖ホテル)
    • Year and Date
      2012-02-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Systemic immunosuppression initiated by Snail^+tumor cells metastasizing into bone marrow via generation of immunoregulatory mesenchymal stem cells2011

    • Author(s)
      工藤千恵
    • Organizer
      日本免疫学会
    • Place of Presentation
      千葉阪
    • Year and Date
      2011-11-28
    • Related Report
      2011 Final Research Report
  • [Presentation] Induction of immunoregulatory mesenchymal stem cells by Snail^+ metastatic tumor cells in bone marrow2011

    • Author(s)
      工藤千恵
    • Organizer
      日本免疫学会
    • Place of Presentation
      千葉(幕張メッセ)
    • Year and Date
      2011-11-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] HERV-H expression in cancer promotes its metastasis by producing immunosuppressive microenviroment2011

    • Author(s)
      工藤千恵
    • Organizer
      日本癌学会
    • Place of Presentation
      愛知(名古屋国際会議場)
    • Year and Date
      2011-10-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] Enhanced metastasis through immunosuppressive cancer microenvironment and its control by targeting signaling molecules2011

    • Author(s)
      河上裕、工藤千恵, 他
    • Organizer
      日本癌学会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-04
    • Related Report
      2011 Final Research Report
  • [Presentation] Enhanced metastasis through immunosuppressive cancer microenvironment and its control by targeting signaling molecules2011

    • Author(s)
      河上裕、工藤千恵, 他
    • Organizer
      日本癌学会
    • Place of Presentation
      愛知(名古屋国際会議場)
    • Year and Date
      2011-10-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] 骨髄転移性癌細胞による全身性免疫抑制の誘導とその阻害法の開発2011

    • Author(s)
      工藤千恵
    • Organizer
      日本がん転移学会
    • Place of Presentation
      浜松
    • Year and Date
      2011-07-01
    • Related Report
      2011 Final Research Report
  • [Presentation] 骨髄転移性癌細胞による全身性免疫抑制の誘導とその阻害法の開発2011

    • Author(s)
      工藤千恵
    • Organizer
      日本がん転移学会
    • Place of Presentation
      静岡(浜松コングレスセンター)
    • Year and Date
      2011-07-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] Systemic immunosuppression initiated by Snail^+tumor cells metastasizing into bone marrow via generation of immunoregulatory mesenchymal stem cells2011

    • Author(s)
      工藤千恵
    • Organizer
      日本がん免疫学会
    • Place of Presentation
      大阪
    • Year and Date
      2011-06-30
    • Related Report
      2011 Final Research Report
  • [Presentation] Systemic immunosuppression initiated by Snail+ tumor cells metastasizing into bone marrow via generation of immunoregulatory mesenchymal stem cells2011

    • Author(s)
      工藤千恵
    • Organizer
      日本がん免疫学会
    • Place of Presentation
      大阪(千里ライフサイエンスセンター)
    • Year and Date
      2011-06-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] がん細胞による免疫抑制機構とその制御2011

    • Author(s)
      河上裕、工藤千恵, 他
    • Organizer
      日本医学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-04-08
    • Related Report
      2011 Final Research Report
  • [Presentation] がん細胞による免疫抑制機構とその制御2011

    • Author(s)
      河上裕、工藤千恵, 他
    • Organizer
      日本医学会総会
    • Place of Presentation
      東京(東京国際フォーラム)
    • Year and Date
      2011-04-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] Identification of the speci fic molecule governing cancer metast asis toward bone2010

    • Author(s)
      不破貴史、工藤千恵, 他
    • Organizer
      日本癌学会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-24
    • Related Report
      2011 Final Research Report
  • [Presentation] Identification of the specific molecule governing cancer metastasis toward bone2010

    • Author(s)
      不破貴史、工藤千恵, 他
    • Organizer
      日本癌学会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] Eradication of cancer metas tasis by breaking a crucial link to systemic immunosuppression underlying poor outcome2010

    • Author(s)
      工藤千恵
    • Organizer
      日本癌学会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-23
    • Related Report
      2011 Final Research Report
  • [Presentation] Eradication of cancer metastasis by breaking a crucial link to systemic immunosuppression underlying poor outcome2010

    • Author(s)
      工藤千恵
    • Organizer
      日本癌学会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] Possible improvement of cancer immunotherapy based on the analyses of anti-tumor immune responses in human2010

    • Author(s)
      河上裕、工藤千恵, 他
    • Organizer
      国際がん生物学シンポジウム
    • Place of Presentation
      金沢
    • Year and Date
      2010-08-28
    • Related Report
      2011 Final Research Report
  • [Presentation] Possible improvement of cancer immunotherapy based on the analyses of anti-tumor immune responses in human2010

    • Author(s)
      河上裕、工藤千恵, 他
    • Organizer
      金沢国際がん生物学シンポジウム
    • Place of Presentation
      金沢
    • Year and Date
      2010-08-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] Immunosuppression by human cancer cells and it's control for effective immunotherapy2010

    • Author(s)
      河上裕、工藤千恵, 他
    • Organizer
      国際免疫学会
    • Place of Presentation
      神戸
    • Year and Date
      2010-08-27
    • Related Report
      2011 Final Research Report
  • [Presentation] Immunosuppression by human cancer cells and it's control for effective immunotherapy2010

    • Author(s)
      河上裕、工藤千恵, 他
    • Organizer
      日本免疫学会
    • Place of Presentation
      神戸
    • Year and Date
      2010-08-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] Immunosuppression mediated by mesenchymal stem cells and Treg cells during Snail-induced cancer EMT2010

    • Author(s)
      工藤千恵, 他
    • Organizer
      国際免疫学会
    • Place of Presentation
      神戸
    • Year and Date
      2010-08-26
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] CCL2 is critical for immunoresistance in association with cancer EMT2010

    • Author(s)
      工藤千恵, 他
    • Organizer
      米国癌学会
    • Place of Presentation
      ワシントンDC
    • Year and Date
      2010-04-21
    • Related Report
      2011 Final Research Report
  • [Presentation] CCL2 is critical for immunoresistance in association with cancer EMT2010

    • Author(s)
      工藤千恵, 他
    • Organizer
      米国癌学会議
    • Place of Presentation
      米国(ワシントンDC)
    • Year and Date
      2010-04-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] Translational research for cancer therapy based on immunological analysis of the interaction between cancer EMT and host immunity2009

    • Author(s)
      工藤千恵
    • Organizer
      日本免疫学会
    • Place of Presentation
      大阪
    • Year and Date
      2009-12-04
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] Systemic immunosuppression induced by preferential metastasis of Snail^+cancer cells into bone marrow2009

    • Author(s)
      工藤千恵, 他
    • Organizer
      日本免疫学会
    • Place of Presentation
      大阪
    • Year and Date
      2009-12-03
    • Related Report
      2011 Final Research Report
  • [Presentation] Systemic immunosuppression induced by preferential metastasis of Snail+ cancer cells into bone marrow2009

    • Author(s)
      工藤千恵(代表)
    • Organizer
      日本免疫学会
    • Place of Presentation
      大阪
    • Year and Date
      2009-12-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] Cancer metastasis and multiple immunosuppressions simultaneously caused by Snail-induced EMT in cancer cells2009

    • Author(s)
      工藤千恵
    • Organizer
      日本癌学会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-03
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] Immunosuppressive microenvironment induced by cancer cells with HERV emergence2009

    • Author(s)
      工藤千恵(代表)
    • Organizer
      日本癌学会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] An endogenous retrovirus antigen regulating both cancer metastasis and immunosuppression2009

    • Author(s)
      工藤千恵(代表)
    • Organizer
      日本がん免疫学会
    • Place of Presentation
      小倉
    • Year and Date
      2009-06-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] Immunoescape of cancer cells expressing an endogenous retrovirus antigen2009

    • Author(s)
      工藤千恵(代表)
    • Organizer
      米国癌学会議
    • Place of Presentation
      米国(デンバー)
    • Year and Date
      2009-04-21
    • Related Report
      2009 Annual Research Report
  • [Remarks] NHK全国ニュース(2010年10月11日)

    • URL

      http://www3.nhk.or.jp/news/html/20101011/k10014510371000.html

    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] がんワクチン2011

    • Inventor(s)
      工藤千恵
    • Industrial Property Rights Holder
      慶應義塾
    • Filing Date
      2011-03-29
    • Related Report
      2011 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] がんワクチン2011

    • Inventor(s)
      工藤千恵
    • Industrial Property Rights Holder
      慶應義塾
    • Filing Date
      2011-03-29
    • Related Report
      2010 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 抗腫瘍剤およびそのスクリーニング法2010

    • Inventor(s)
      工藤千恵
    • Industrial Property Rights Holder
      慶應義塾
    • Filing Date
      2010-09-29
    • Related Report
      2011 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 抗腫瘍剤およびそのスクリーニング法2010

    • Inventor(s)
      工藤千恵
    • Industrial Property Rights Holder
      慶應義塾
    • Filing Date
      2010-09-29
    • Related Report
      2010 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] がんの診断方法と治療方法2009

    • Inventor(s)
      工藤千恵
    • Industrial Property Rights Holder
      慶應義塾
    • Filing Date
      2009-09-11
    • Related Report
      2011 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] がんの診断方法と治療方法2009

    • Inventor(s)
      工藤千恵
    • Industrial Property Rights Holder
      慶応義塾
    • Filing Date
      2009-09-11
    • Related Report
      2009 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 抗腫瘍剤およびそのスクリーニング法2009

    • Inventor(s)
      工藤千恵
    • Industrial Property Rights Holder
      慶応義塾
    • Industrial Property Number
      2009-225034
    • Filing Date
      2009-09-29
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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