Bone-metastatic tumor cells induce systemic immunosuppression through increase of immunoregulatory mesenchymal stem cells
| Project/Area Number |
21590445
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Keio University |
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Principal Investigator |
KUDO Chie 慶應義塾大学, 医学部, 講師 (90424126)
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| Co-Investigator(Kenkyū-buntansha) |
KAWAKAMI Yutaka 慶應義塾大学, 医学部, 教授 (50161287)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | がん / 骨転移 / 免疫抑制 / 上皮間葉転換 / Snail / 骨髄 |
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| Research Abstract |
Bone metastasis is frequently caused in cancer patients, and negatively affect their quality of life. However, there are no treatments to inhibit cancer metastasis toward bone itself. We found that Snail^+cancer cells preferentially metastasize into bone marrow than other organs, and produce systemic immunosuppression mediating via expansion of various immunoregulatory cells. We identified the Snail-downstream molecules that induce cancer metastasis and increase mesenchymal stem cells. These molecules would be good targets for cancer therapy to efficiently inhibit bone metastasis of cancer cells by breaking a crucial link to immunosuppression.
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Report
(4 results)
Research Products
(41 results)
