| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Research Abstract |
Bone metastasis is frequently caused in cancer patients, and negatively affect their quality of life. However, there are no treatments to inhibit cancer metastasis toward bone itself. We found that Snail^+cancer cells preferentially metastasize into bone marrow than other organs, and produce systemic immunosuppression mediating via expansion of various immunoregulatory cells. We identified the Snail-downstream molecules that induce cancer metastasis and increase mesenchymal stem cells. These molecules would be good targets for cancer therapy to efficiently inhibit bone metastasis of cancer cells by breaking a crucial link to immunosuppression.
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