| Project/Area Number |
21590447
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Kansai Medical University |
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Principal Investigator |
ADACHI Yasushi 関西医科大学, 医学部, 非常勤講師 (10268336)
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| Co-Investigator(Renkei-kenkyūsha) |
MINAMINO Keizo 関西医科大学, 医学部, 助教 (40509585)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 疾患モデル動物 / 骨髄内骨髄移植 / マグネット・ビーズ / 骨髄移植 / マグネット / マウス / ラット / マグネットビーズ / 長期観察 / 造血 / マグネ / 末梢血 / 骨髄細胞 / 動物実験 / 骨髄 / day12 CFU-S / 細胞保持 / 造血促進 |
|---|
| Research Abstract |
Intra-bone marrow-bone-marrow transplantation(IBM-BMT) is more efficientmethod for bone marrow transplantation than conventionalintra-venous bone marrow transplantation(BMT). In this study, we used magnet-beads and a magnet for IBM-BMT. First, we coated donor bone marrow cells(BMCs) with magnet-beads. Next, we transplantedthe donor BMCs into the recipient bone marrow of the tibia. A powerful magnet wascircumferentiallyset around the bone when the donor BMCs were injected into the bone. IBM-BMT with magnet-beads and a magnet showed rapid hematopoiesis of donor BMCs.
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