Development of efficient bone marrow transplantation and its application for treatment of malignant tumor or regeneration therapy

• Project/Area Number: 21590447
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: Kansai Medical University
• Principal Investigator: ADACHI Yasushi 関西医科大学, 医学部, 非常勤講師 (10268336)
• Co-Investigator(Renkei-kenkyūsha): MINAMINO Keizo 関西医科大学, 医学部, 助教 (40509585)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 疾患モデル動物 / 骨髄内骨髄移植 / マグネット・ビーズ / 骨髄移植 / マグネット / マウス / ラット / マグネットビーズ / 長期観察 / 造血 / マグネ / 末梢血 / 骨髄細胞 / 動物実験 / 骨髄 / day12 CFU-S / 細胞保持 / 造血促進

Research Abstract

Intra-bone marrow-bone-marrow transplantation(IBM-BMT) is more efficientmethod for bone marrow transplantation than conventionalintra-venous bone marrow transplantation(BMT). In this study, we used magnet-beads and a magnet for IBM-BMT. First, we coated donor bone marrow cells(BMCs) with magnet-beads. Next, we transplantedthe donor BMCs into the recipient bone marrow of the tibia. A powerful magnet wascircumferentiallyset around the bone when the donor BMCs were injected into the bone. IBM-BMT with magnet-beads and a magnet showed rapid hematopoiesis of donor BMCs.

Research Products

• [Journal Article] 効率の良い骨髄移植法の開発とその応用-動物モデルを用いた研究の重要性- (2012)
  • Author(s): 足立靖、沖垣光彦、杉原昭、越路みのり、小柳津治樹、池袋一哉、冨田実、南野桂三、鈴木康弘、張玉明、金田浩由紀、岩崎真佳、小池保志、中野景司、向出裕美、重松明男、小池直子、石明、矢内誠司、今井雄二郎、嶋千絵子、下智比古、池原進
  • Journal Title: 公立豊岡病院紀要 Volume: No.23 Pages: 39-45
  • Peer Reviewed
• [Journal Article] Diagnostic utility of vitreous humor fluid cytology for intraocular sarcoidosis : A clinicopathologic study of 7 cases (2012)
  • Author(s): Kinoshita Y, Takasu K, Adachi Y, 他4人、3番目
  • Journal Title: Diagn Cytopathol Volume: 40 Pages: 210-213
  • Peer Reviewed
• [Journal Article] Dehydroxymethylepoxyquinomicin(DHMEQ) can suppress tumour necrosis factor-α production in lipopolysaccharide-injected mice, resulting in rescuing mice from death in vivo (2011)
  • Author(s): Shimo T, Adachi Y, Umezawa K, Okigaki M, Takaya J, Taniuchi S, Ikehara S, Kaneko K
  • Journal Title: Clin Exp Immunol Volume: vol.166, No.2 Pages: 299-306
  • Peer Reviewed
• [Journal Article] Early Inflammatory Reactions in Atherosclerosis Are Induced by Tyrosine Kinase Proline-Rich Tyrosine Kinase/Reactive Oxygen Species-Mediated Release of Tumor Necrosis Factor-{alpha} and Subsequent Activation of the p21Cip1/Ets-1/p300 System (2011)
  • Author(s): Katsume A, Okigaki M, Matsui A, Che J, Adachi Y, Kishita E, Yamaguchi S, Ikeda K, Ueyama T, Matoba S, Yamada H, Matsubara H
  • Journal Title: Arterioscler Thromb Vasc Biol Volume: vol.31, No.5 Pages: 1084-92
  • Peer Reviewed
• [Journal Article] Combination of intra-bone marrow-bone marrow transplantation and subcutaneous donor splenocyte injection diminishes risk of GVHD and enhances survival rate (2011)
  • Author(s): Shi M, Adachi Y, Cui Y, Li M, Lian Z, Zhang Y, Yanai S, Shima C, Imai Y, Ikehara S
  • Journal Title: Stem Cells Dev Volume: vol.20, No.5 Pages: 759-68
  • Peer Reviewed
• [Journal Article] Endothelial FGF receptor signaling accelerates atherosclerosis (2011)
  • Author(s): Che J, Okigaki M, Takahashi T, Katsume A, Adachi Y, Yamaguchi S, Matsunaga S, Takeda M, Matsui A, Kishita E, Ikeda K, Yamada H, Matsubara H
  • Journal Title: Am J Physiol Heart Circ Physiol Volume: Vol.300, No.1
  • Peer Reviewed
• [Journal Article] Klotho is associated with VEGF receptor-2 and the transient receptor potential canonical-1 Ca2+channel to maintain endothelial integrity (2011)
  • Author(s): Kusaba T, Okigaki M, Matui A, Murakami M, Ishikawa K, Kimura T, Sonomura K, Adachi Y, Shibuya M, Shirayama T, Tanda S, Hatta T, Sasaki S, Mori Y, Matsubara H
  • Journal Title: Proc Natl Acad Sci USA Volume: Vol.107, No.45 Pages: 19308-13
  • Peer Reviewed
• [Journal Article] Endothelial FGF receptor signaling accelerates atherosclerosis (2011)
  • Author(s): Che J, Okigaki M, Takahashi T, Katsume A, Adachi Y, 他8人5番目
  • Journal Title: Am J Physiol Heart Circ Physiol Volume: 300
  • Peer Reviewed
• [Journal Article] Combination of intra-bone marrow-bone marrow transplantation and subcutaneous donor splenocyte injection diminishes risk of GVHD and enhances survival rate (2011)
  • Author(s): Shi M, Adachi Y, 他8人2番目
  • Journal Title: Stem Cells Dev Volume: 20 Pages: 759-768
  • Peer Reviewed
• [Journal Article] Endometrial clear cell adenocarcinoma diagnosed by endometrial cytological examination : two cases report (2011)
  • Author(s): Kinoshita Y, Takasu K, Adachi Y, Yuri T, Ikuta A, Shikata N
  • Journal Title: Diagn Cytopathol Volume: 39 Pages: 200-203
  • Peer Reviewed
• [Journal Article] Early Inflammatory Reactions in Atherosclerosis Are Induced by Tyrosine Kinase Proline-Rich Tyrosine Kinase/Reactive Oxygen Species-Mediated Release of Tumor Necrosis Factor-{alpha} and Subsequent Activation of the p21Cip1/Ets-1/p300 System (2011)
  • Author(s): Katsume A, Okigaki M, Matsui A, Che J, Adachi Y, 他7人の5番目
  • Journal Title: Arterioscler Thromb Vasc Biol Volume: 31 Pages: 1084-1092
  • Peer Reviewed
• [Journal Article] Antiplatelet antibody may cause delayed transfusion-related acute lung injury (2011)
  • Author(s): Torii Y, Shimizu T, Yokoi T, Sugimoto H, Katashiba Y, Ozasa R, Fujita S, Adachi Y, 他2人、8番目
  • Journal Title: Int J Gen Med Volume: 4 Pages: 677-680
  • Peer Reviewed
• [Journal Article] Dehydroxymethylepoxyquinomicin (DHMEQ) can suppress tumour necrosis factor-α production in lipopolysaccharide-injected mice, resulting in rescuing mice from death in vivo (2011)
  • Author(s): Shimo T, Adachi Y, 他6人、2番目
  • Journal Title: Clin Exp Immunol Volume: 166 Pages: 299-306
  • Peer Reviewed
• [Journal Article] Endothelial FGF receptor signaling accelerates atherosclerosis. (2011)
  • Author(s): Che J, Okigaki M, Takahashi T, Katsume A, Adachi Y, Yamaguchi S, Matsunaga S, Takeda M, Matsui A, Kishita E, Ikeda K, Yamada H, Matsubara H
  • Journal Title: Am J Physiol Heart Circ Physiol Volume: 300
  • Peer Reviewed
• [Journal Article] Endometrial clear cell adenocarcinoma diagnosed by endometrial cytological examination : two cases report. (2011)
  • Author(s): Kinoshita Y, Takasu K, Adachi Y, Yuri T, Ikuta A, Shikata N.
  • Journal Title: Diagn Cytopathol. Volume: 39 Pages: 200-203
  • Peer Reviewed
• [Journal Article] Signaling from Fibroblast Growth Factor Receptor 2 in Immature Hematopoietic Cells Facilitates Donor Hematopoiesis after Intra-Bone Marrow-Bone Marrow Transplantation (2010)
  • Author(s): Shigematsu A, Shi M, Okigaki M, Adachi Y, Koike N, Che J, Iwasaki M, Matsubara H, Imamura M, Ikehara S
  • Journal Title: Stem Cells Dev Volume: vol.19, No.11 Pages: 1679-86
  • NAID: 120005946692
  • Peer Reviewed
• [Journal Article] Bone marrow-derived stromal cells can express neuronal markers by DHA/GPR40 signaling (2010)
  • Author(s): Kaplamadzhiev DB, Hisha H, Adachi Y, Ikehara S, Tonchev AB, Boneva NB, Pyko IV, Kikuchi M, Nakaya M, Wakayama T, Iseki S, Yamashima T
  • Journal Title: Biosci Trends Volume: vol.4, No.3 Pages: 119-29
  • Peer Reviewed
• [Journal Article] Combination Method of Magnetic Beads and Magnet Helps Sustain Number of Donor Bone Marrow Cells after Intra-Bone Marrow Injection, Resulting in Rapid Hemopoietic Recovery (2010)
  • Author(s): Shima C, Adachi Y, Shi M, Imai Y, Okigaki M, Yanai S, Takahashi K, Ikehara S
  • Journal Title: Bone Marrow Transplant Volume: vol.45, No.6 Pages: 993-9
• [Journal Article] Adult bone marrow cells can differentiate into hemopoietic cells and endothelial cells but not into other lineage cells in normal growth and normal life (2010)
  • Author(s): Yanai S, Adachi Y, Shi M, Shigematsu A, Shima C, Imai Y, Kwon AH, Ikehara S
  • Journal Title: Int J Hematol Volume: vol.91 Pages: 213-8
  • NAID: 10026111299
  • Peer Reviewed
• [Journal Article] Caspase Inhibitor, ZVAD-fmk, FacilitatesEngraftment of Donor Hematopoietic Stem Cells in Intra-Bone Marrow-Bone Marrow Transplantation (2010)
  • Author(s): Imai Y, Adachi Y, Shi M, Shima C, Yanai S, Okigaki M, Yamashima T, Kaneko K, Ikehara S
  • Journal Title: Stem Cells Dev Volume: vol.19 Pages: 461-8
  • Peer Reviewed
• [Journal Article] Caspase Inhibitor, ZVAD-fmk, Facilitates Engraftment of Donor Hematopoietic Stem Cells in Intra-Bone Marrow-Bone Marrow Transplantation (2010)
  • Author(s): Imai Y, Adachi Y, Shi M, Shima C, Yanai S, Okigaki M, Yamashima T, Kaneko K, Ikehara S
  • Journal Title: Stem Cells Dev Volume: 19 Pages: 461-468
  • Peer Reviewed
• [Journal Article] Combination Method of Magnetic Beads and Magnet Helps Sustain Number of Donor Bone Marrow Cells after Intra-Bone Marrow Injection, Resulting in Rapid Hemopoietic Recovery (2010)
  • Author(s): Shima C, Adachi Y, Shi M, Imai Y, Okigaki M, Yanai S, Takahashi K, Ikehara S
  • Journal Title: Bone Marrow Transplant. Volume: 45 Pages: 993-999
  • Peer Reviewed
• [Journal Article] Signaling from Fibroblast Growth Factor Receptor 2 in Immature Hematopoietic Cells Facilitates Donor Hematopoiesis after Intra-Bone Marrow-Bone Marrow Transplantation. (2010)
  • Author(s): Shigematsu A, Shi M, Okigaki M, Adachi Y, Koike N, Che J, Iwasaki M, Matsubara H, Imamura M, Ikehara S.
  • Journal Title: Stem Cells Dev. Volume: 19 Pages: 1679-1686
  • NAID: 120005946692
  • Peer Reviewed
• [Journal Article] Klotho is associated with VEGF receptor-2 and the transient receptor potential canonical-1 Ca2+ channel to maintain endothelial integrity (2010)
  • Author(s): Kusaba T, Okigaki M, Matui A, Murakami M, Ishikawa K, Kimura T, Sonomura K, Adachi Y, Shibuya M, Shirayama T, Tanda S, Hatta T, Sasaki S, Mori Y, Matsubara H
  • Journal Title: Proc Natl Acad Sci USA Volume: 107 Pages: 19308-19313
  • Peer Reviewed
• [Journal Article] 嚢胞構造を呈した肝原発カルチノイド腫瘍の一例 (2010)
  • Author(s): 松永志保、四方伸明、木下勇一、濱口記久子、圦貴司、鷹巣晃昌、足立靖
  • Journal Title: 日本臨床細胞学会雑誌 Volume: 49 Pages: 216-220
  • Peer Reviewed
• [Journal Article] Adult bone marrow cells can differentiate into hemopoietic cells and endothelial cells but not into other lineage cells in normal growth and normal life (2010)
  • Author(s): Yanai S, Adachi Y, Shi M, Shigematsu A, Shima C, Imai Y, Kwon AH, Ikehara S.
  • Journal Title: Int J Hematol 91 Pages: 213-218
  • NAID: 10026111299
  • Peer Reviewed
• [Journal Article] Abnormal distribution of dendritic cells in(NZW x BXSB)F1 mice (2010)
  • Author(s): Tokuyama Y, Adachi Y, Minamino K, Shintaku H, Okigaki M, Hayashi K, Kitajima A, Takaki T, Koike N, Shima C, Imai Y, Shi M, Yanai S, Ikehara S.
  • Journal Title: Autoimmunity 42 Pages: 399-405
  • Peer Reviewed
• [Journal Article] Intra-bone marrow-bone marrow transplantation slows disease progression and prolongs survival in G93A mutant SOD1 transgenic mice, an animal model mouse for amyotrophic lateral sclerosis (2010)
  • Author(s): Ohnishi S, Ito H, Suzuki Y, Adachi Y, Wate R, Zhang J, Nakano S, Kusaka H, Ikehara S.
  • Journal Title: Brain Res. 1296 Pages: 216-219
  • Peer Reviewed
• [Journal Article] Intra-bone marrow transplantation slows disease progression and prolongs survival in G93A mutant SOD1 transgenic mice, a model mouse for amyotrophic lateral sclerosis (2009)
  • Author(s): Ohnishi S, Ito H, Suzuki Y, Adachi Y, Wate R, Zhang J, Nakano S, Kusaka H, Ikehara S
  • Journal Title: Brain Res Volume: vol.1296 Pages: 216-24
  • Peer Reviewed
• [Journal Article] Abnormal distribution of dendritic cells in(NZWxBXSB) F1mice (2009)
  • Author(s): Tokuyama Y, Adachi Y, Minamino K, Shintaku H, Okigaki M, Hayashi K, Kitajima A, Takaki T, Koike N, Shima C, Imai Y, Shi M, Yanai S, Ikehara S
  • Journal Title: Autoimmunity Volume: vol.42 Pages: 399-405
  • Peer Reviewed
• [Journal Article] Anti-tumor effectsof fusion Cells oftype 1 dendritic cells and tumor cells(Meth A) using Hemagglutinating Virus of Japan-Envelope(HVJ-E) (2009)
  • Author(s): Yanai S, AdachiY, Fujisawa JI, JiangSW, Okigaki M, Shi M, Shima C, Imai Y, Kwon AH, Ikhara S
  • Journal Title: Int J Oncol Volume: vol.35 Pages: 249-255
  • Peer Reviewed
• [Journal Article] Endothelium-targeted overexpression of constitutively active FGF receptor induces cardioprotection in mice myocardial infarction (2009)
  • Author(s): Matsunaga S, Okigaki M, Takeda M, Matsui A, Honsho S, Katsume A, Kishita E, Jishan C, Kurihara T, Adachi Y, Mansukhani A, Kobara M, MatobaY, Tatsumi T, Matsubara H
  • Journal Title: J Mol Cell Cardiol Volume: vol.46, No.5 Pages: 663-73
  • Peer Reviewed
• [Journal Article] Anti-tumor effects of fusion cells of type 1 dendritic cells and Meth A tumor cells using hemagglutinating virus of Japan-envelope (2009)
  • Author(s): Yanai S, Adachi Y, Fuijisawa J, Jiang S, Okigaki M, Shi M, Shima C, Imai Y, Kwon AH, Ikehara S.
  • Journal Title: Int J Oncol. 35 Pages: 249-255
  • Peer Reviewed
• [Presentation] より効率的な骨髄内骨髄移植法の開発-マグネット・ビーズを用いて- (2012)
  • Author(s): 足立靖、嶋千絵子、南野桂三、石明、高橋寛二、池原進
  • Organizer: 第11回日本再生医療学会総会
  • Place of Presentation: 横浜(パシフィコ横浜)
• [Presentation] マグネット・ビーズを用いた骨髄内骨髄移植法 (2012)
  • Author(s): 石明、嶋千絵子、足立靖、南野桂三、高橋寛二、池原進
  • Organizer: 第101回日本病理学会総会
  • Place of Presentation: 東京(京王プラザホテル)
• [Presentation] LPS投与マウスにおけるDHMEQ(NF-κB inhibitor)の効果 (2012)
  • Author(s): 足立靖、下智比古、梅澤一夫、金子一成、池原進
  • Organizer: 第101回日本病理学会総会
  • Place of Presentation: 東京(京王プラザホテル)
• [Presentation] Heparin mobilizes multipotent human mesoangioblasts (2011)
  • Author(s): Fujitaka K, Iwasaki M, Sato D, Park H, Enoki C, Koyanagi M, Minato N, Otani H, Nishikawa M, Adachi Y, Ikehara S, Zeiher AM, Dimmeler S, Iwasaka T
  • Organizer: American Heart Association(AHA) scientific sessions 2011
  • Place of Presentation: Orland, Florida, USA(Orange Country Convention Center)
• [Presentation] エンドトキシンショックにおけるNF-κB阻害剤の有用性:マウスを用いた検討 (2011)
  • Author(s): 下智比古、高屋淳二、谷内昇一郎、足立靖、金子一成
  • Organizer: 第114回日本小児科学会総会・学術集会
  • Place of Presentation: 東京(グランドプリンスホテル新高輪国際館パミール、グランドプリンスホテル高輪)
• [Presentation] Dehydroxymethylepoxyquinomicin(DHMEQ), a novel inhibitor for NF-κB, ameliorates proteinuria in murine puromycin-aminonucleoside-induced nephrosis (2011)
  • Author(s): Shimo T, Adachi Y, Kimata T, Umezawa K, Ikehara S, Kaneko K
  • Organizer: The 11th AsianCongress of Pediatric Nephrology
  • Place of Presentation: Fukuoka, Japan(福岡国際会議場)
• [Presentation] 網膜虚血再灌流モデルに対するG-CSFの効果 (2011)
  • Author(s): 嶋千絵子、足立靖、南野桂三、池原進、高橋寛二
  • Organizer: 第115回日本眼科学会総会
  • Place of Presentation: 東京東京国際フォーラム
• [Presentation] アポトーシス阻害薬Z-VAD-fmkを用いた効率のよい骨髄内骨髄移植法 (2011)
  • Author(s): 足立靖、今井雄一郎、石明、池原進
  • Organizer: 第100回日本病理学会学術集会
  • Place of Presentation: 横浜(パシフィコ横浜)
• [Presentation] アポトーシス阻害薬Z-VAD-fmkを用いた効率のよい骨髄内骨髄移植法 (2011)
  • Author(s): 足立靖, 他3名1番目
  • Organizer: 第100回日本病理学会総会・学術集会
  • Place of Presentation: 横浜;パシフィコ横浜
• [Presentation] 網膜虚血再灌流モデルに対するG-CSFの効果 (2011)
  • Author(s): 嶋千絵子、足立靖, 他3名2番目
  • Organizer: 第115回日本眼科学会総会
  • Place of Presentation: 東京;東京国際フォーラム
• [Presentation] Dehydroxymethylepoxyquinomicin (DHMEQ), a novel inhibitor for NF-κB, ameliorates proteinuria in murine puromycin-aminonucleoside-induced nephrosis (2011)
  • Author(s): Shimo Tomohiko, Yasushi Adachi, 他4人2番目
  • Organizer: The 11th Asian Congress of Pediatric Nephrology
  • Place of Presentation: 福岡;福岡国際会議場
• [Presentation] エンドトキシンショックにおけるNF-κB阻害剤の有用性:マウスを用いた検討 (2011)
  • Author(s): 下智比古、高屋淳二、谷内昇一郎、足立靖、金子一成
  • Organizer: 第114回日本小児科学会学術集会
  • Place of Presentation: 東京;グランドプリンスホテル新高輪
• [Presentation] Heparin mobilizes multipotent human mesoangioblasts (2011)
  • Author(s): Keisuke Fujitaka, Masayoshi Iwasaki, Yasushi Adachi, 他11人10番目
  • Organizer: American Heart Association scientific sessions 2011
  • Place of Presentation: Orland, Florida, USA ; Orange Country Convention Center
• [Presentation] 骨髄内骨髄移植と皮下donor lymphocyte infusionの組み合わせ効果 (2010)
  • Author(s): 石明、足立靖、池原進
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 東京京王プラザ
• [Presentation] 胸腺移植を併用した骨髄内骨髄移植の悪性腫瘍に対する効果:胎生、新生仔、成体期の胸腺と造血幹細胞の比較 (2010)
  • Author(s): 保坂直樹、高木孝士、足立靖、池原進
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 東京京王プラザ
• [Presentation] 骨髄内骨髄移植と皮下donor lymphocyte infusionの組み合わせ効果 (2010)
  • Author(s): 石明、足立靖、池原進
  • Organizer: 第99回日本病理学会
  • Place of Presentation: 東京(京王プラザ)
• [Presentation] 胸腺移植を併用した骨髄内骨髄移植の悪性腫瘍に対する効果:胎生、新生仔、成体期の胸腺と造血幹細胞の比較 (2010)
  • Author(s): 保坂直樹、高木孝士、足立靖、池原進
  • Organizer: 第99回日本病理学会
  • Place of Presentation: 東京(京王プラザ)
• [Presentation] 頭部皮膚転移が診断の契機となった肉腫型胸膜悪性中皮腫の1例 (2010)
  • Author(s): 高畠希、南雲サチ子、木下勇一、松永志保、市邊和男、足立靖、圦貴司、鷹巣晃昌、四方伸明
  • Organizer: 第51回日本臨床細胞学会(春期大会)
  • Place of Presentation: 横浜(パシフィコ横浜)
• [Presentation] 上皮様の細胞像を呈したGISTの1例 (2010)
  • Author(s): 長岡克也、大垣日登美、足立靖、鷹巣晃昌、槇政彦、保坂直樹、長田憲和
  • Organizer: 第49回日本臨床細胞学会秋期大会
  • Place of Presentation: 神戸(神戸ポートピアホテル)
• [Presentation] 子宮内膜未分化肉腫を肉腫成分とした子宮体部癌肉腫の1例 (2010)
  • Author(s): 圦貴司、足立靖、鷹巣晃昌、四方伸明、生田明子、南雲サチ子、高畠希、市邊和男、赤松孝子、螺良愛郎
  • Organizer: 第49回日本臨床細胞学会秋期大会
  • Place of Presentation: 神戸(神戸ポートピアホテル)
• [Presentation] 目内悪性リンパ腫18例の検討 (2010)
  • Author(s): 木下勇一、足立靖、圦貴司、市邊和男、松永志保、高畠希、李重煥、南雲サチ子、鷹巣晃昌、四方伸明
  • Organizer: 第49回日本臨床細胞学会秋期大会
  • Place of Presentation: 神戸(神戸ポートピアホテル)
• [Presentation] Tie2発現細胞特異的にFGFレセプター2を発現させたトランスジェニックマウスにおける造血系細胞の解析 (2009)
  • Author(s): 足立靖、石明、矢内勢司、嶋千絵子、今井雄一郎、池原進
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 京都(京都国際会議場)
  • Year and Date: 2009-05-01
• [Presentation] 特別シンポジウムより効率的な骨髄内骨髄移植の検討-コラーゲン・ゲル或いはマグネット・ビーズを用いて (2009)
  • Author(s): 足立靖、石明、池原進
  • Organizer: 第45回日本移植学会
  • Place of Presentation: 東京
• [Presentation] 骨髄由来樹状細胞の骨内投与による抗腫瘍効果の検討 (2009)
  • Author(s): 嶋千絵子、足立靖、石明、矢内勢司、今井雄一郎、高橋寛二、池原進
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 京都(国際会議場)
• [Presentation] 樹状細胞とマウス線維肉腫との融合細胞を用いた抗腫瘍効果の検討 (2009)
  • Author(s): 矢内勢司、足立靖、石明、嶋千絵子、今井雄一郎、池原進
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 京都(京都国際会議場)
• [Presentation] 骨髄内骨髄移植法におけるコラーゲン・ゲルの有用性 (2009)
  • Author(s): 石明、足立靖、矢内勢司、嶋千絵子、今井雄一郎、池原進
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 京都(京都国際会議場)
• [Presentation] より効率的な骨髄内骨髄移植の検討―コラーゲン・ゲル或いはマグネット・ビーズを用いて (2009)
  • Author(s): 足立靖, 石明, 池原進
  • Organizer: 第45回 日本移植学会
  • Place of Presentation: 東京(京王プラザホテル)
• [Presentation] Tie2発現細胞特異的にFGFレセプター2を発現させたトランスジェニックマウスにおける造血系細胞の解析 (2009)
  • Author(s): 足立靖, 石明, 矢内勢司, 嶋千絵子, 今井雄一郎, 池原進
  • Organizer: 第98回 日本病理学会総会
  • Place of Presentation: 京都(国際会議場)
• [Presentation] 骨髄由来樹状細胞の骨髄内投与による抗腫瘍効果の検討 (2009)
  • Author(s): 嶋千絵子, 足立靖, 石明, 矢内勢司, 今井雄一郎, 高橋寛二, 池原進
  • Organizer: 第98回 日本病理学会総会
  • Place of Presentation: 京都(国際会議場)
• [Presentation] 樹状細胞とマウス線維肉腫との融合細胞を用いた抗腫瘍効果の検討 (2009)
  • Author(s): 矢内勢司, 足立靖, 石明, 嶋千絵子, 今井雄一郎, 池原進
  • Organizer: 第98回 日本病理学会総会
  • Place of Presentation: 京都(国際会議場)
• [Presentation] 骨髄内骨髄移植法におけるコラーゲン・ゲルの有用性 (2009)
  • Author(s): 石明, 足立靖, 矢内勢司, 嶋千絵子, 今井雄一郎, 池原進
  • Organizer: 第98回 日本病理学会総会
  • Place of Presentation: 京都(国際会議場)
• [Presentation] 骨髄移植後のマウスに発生したドナー由来未熟白血病細胞株の樹立とその解析 (2009)
  • Author(s): 今井雄一郎, 足立靖, 比舎弘子, 石明, 矢内勢司, 嶋千絵子, 金子一成, 池原進
  • Organizer: 第98回 日本病理学会総会
  • Place of Presentation: 京都(国際会議場)